Results 271 to 280 of about 19,695,084 (324)

Studies on the decomposition of the oxime HI 6 in aqueous solution

Archives of Toxicology, 1986
HI 6 has been shown to be efficacious in soman intoxication of laboratory animals by reactivation of acetylcholinesterase. To assess possible risks involved in the administration of HI 6 its degradation products were analyzed at pH 2.0, 4.0, 7.4, and 9.0.
P, Eyer, W, Hell, A, Kawan, H, Klehr
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Superior efficacy of HI-6 dimethanesulfonate over pralidoxime methylsulfate against Russian VX poisoning in cynomolgus monkeys (Macaca fascicularis).

Toxicology, 2018
Organophosphorus nerve agents still represent a serious risk to human health. In the French armed forces, the current emergency treatment against OP intoxications is a fully licensed wet-dry dual-chambered autoinjector (Ineurope ®), that contains ...
C. Reymond, N. Jaffré, N. Taudon, M. Menneteau, H. Chaussard, J. Denis, C. Castellarin, F. Dhote, F. Dorandeu   +8 more
semanticscholar   +1 more source

Study on the stability of the oxime HI 6 in aqueous solution

Archives of Toxicology, 1988
HI 6 (Pyridinium, 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydro xyimino) methyl]-dichloride is an effective antidote against poisoning with extremely toxic organophosphates. Because of conflicting reports on the stability of HI 6 in aqueous solutions, we studied the factors influencing its stability. HI 6 has been shown to be most stable in
P, Eyer, I, Hagedorn, B, Ladstetter
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Cardiopulmonary effects of HI-6 treatment in soman intoxication

Journal of Applied Toxicology, 2001
The cardiopulmonary effects of HI-6, together with atropine and soman, were studied in the rat. HI-6 is an effective antidote in acute poisoning with the nerve agent soman. The therapeutic efficiency of HI-6 is still unclear and cannot be explained entirely by the HI-6 reactivating ability of acetylcholinesterase (AChE).
A, Göransson-Nyberg, G, Cassel
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Bioavailability and disposition kinetics of HI‐6 in Beagle dogs

Biopharmaceutics & Drug Disposition, 1993
AbstractThe absorption and disposition kinetics of HI‐6 were determined in Beagle dogs given single doses (25 mg kg−1) of the drug by the intravenous, intramuscular, and oral routes. Concentrations of the oxime in plasma and urine were measured by HPLC.
J D, Baggot, A, Buckpitt, D, Johnson, P, Brennan, H, Chung   +4 more
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HI-6 Therapy and the acute phase response in the rat

Toxicology, 1996
The propensity of therapeutic doses of HI-6 (50 mg/kg) in combination with atropine sulphate (17 mg/kg), antidotes used to treat organophosphate poisoning, to induce the acute phase response (APR) in the laboratory rat was examined. A single intraperitoneal injection of HI-6, either alone or with atropine, caused a rapid doubling of the plasma ...
S, Ivanović-Matić, G, Poznanović
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Non-reactivating effects of HI-6 on hippocampal neurotransmission

Archives of Toxicology, 1994
Effects of the oxime HI-6, unrelated to reactivation of acetylcholinesterase (AChE), on field potentials in the dentate gyrus of the rat hippocampus following AChE inhibition, were investigated both in vitro and in vivo. In hippocampal slices, AChE inhibition decreased the perforant path evoked population spike amplitude (PSA).
Melchers, B.P.C., Laaken, A.L. van der, Busker, R.W., Bruijnzeel, P.L.B., Helden, H.P.M. van   +4 more
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HI 6 dimethanesulfonate has better dissolution properties than HI 6 dichloride for application in dry/wet autoinjectors

International Journal of Pharmaceutics, 1996
To oppose the rapid onset of cholinergic crisis after poisoning with highly toxic organophosphorus compounds, atropine in combination with a cholinesterase reactivator should be administered as early as possible. Due to its broader antidotal spectrum against nerve agents, the second-generation oxime HI 6 appears suitable to replace the marketed oximes,
Horst Thiermann, Stephan Seidl, Peter Eyer   +2 more
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DFT conformational studies of the HI‐6 molecule

International Journal of Quantum Chemistry, 2005
AbstractA systematic study of the oxime HI‐6 [1‐(2‐hydroxyiminomethyl‐1‐pyridinium)‐1‐(4‐carboxy‐aminopyridinium)dimethyl ether] hydrochloride, which is one of the most promising antidotes against soman intoxication, was carried out using density functional theory with the B3LYP (Becke, Lee, Yang, and Parr) method and the 6‐31+G*, 6‐31+G*, and 6‐31+G**
Gustavo R. Silva, Itamar Borges, Jose D. Figueroa‐Villar   +2 more
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HI-6 therapy of soman and tabun poisoning in primates and rodents

Archives of Toxicology, 1989
The bis-pyridinium oxime HI-6, in conjunction with atropine, was found to offer significant protection against multiple LD50 challenges with the organophosphorus compounds soman and tabun. In adult rhesus macaques, the therapeutic administration of HI-6 with atropine and diazepam protected three of four animals from the lethal effects of 5 x LD50 of ...
M G, Hamilton, P M, Lundy
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