Results 271 to 280 of about 78,665,240 (283)
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Effects of HI-6 and pralidoxime on neuronal RNA in thalamic cholinergic sites
Journal of the Neurological Sciences, 1985Quantitative azure B-RNA cytophotometry was employed to compare effects of the oximes HI-6 and pralidoxime (2-PAM) to those of atropine sulfate (AS) on neuronal RNA metabolism in the thalamic ventrobasal nuclear complex (VBC) and nucleus reticularis (NR).
L J, Martin, J A, Doebler, A, Anthony
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Distribution of the bispyridinium oxime [14C] HI-6 in male and female rats
Archives of Toxicology, 1990Female rats poisoned with multiple LD50s of soman or tabun have been shown previously to respond to the protective effects of HI-6 more positively than male rats. This present study was designed first to determine the distribution pattern and concentration of [14C] HI-6 in rats, and secondly, to determine the possibility that HI-6 might be located in ...
P M, Lundy +4 more
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Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime
Biochemical Pharmacology, 1986Acetylcholinesterase was purified from human caudate nucleus and skeletal muscle. The enzyme preparations were used to study aging and reactivation by HI-6 and obidoxime after inhibition by soman and its isomers. HI-6 was found to be the most potent reactivator.
G, Puu, E, Artursson, G, Bucht
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Formation of cyanide after i. v. administration of the oxime HI 6 to dogs
Archives of Toxicology, 1987HI 6(pyridinium, 1-[[[4-(aminocarbonyl)pyridinio]methoxy]-2- [(hydroxyimino)methyl]-dichloride belongs to a series of bisquaternary pyridinium oximes that are effective against poisoning with extremely toxic organophosphates. Since HI 6 has been shown to be unstable at pH 7.4 and to release significant amounts of cyanide, a study was undertaken to ...
P, Eyer, A, Kawan, B, Ladstetter
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An optical biosensor based on His 6 -OPH for organophosphate detection
SPIE Proceedings, 2011In this work we describe a method for immobilizing the hexahistidine-modified OPH (His 6 -OPH) enzyme via sol-gel technology in a porous material while retaining its catalytic activity. The potential use of each bio-sensing material was checked by quantifying the enzymatic properties, such as the relative activity of the immobilized enzyme, its ...
Nina Frančič +4 more
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HI-6 modulates immunization efficacy in a BALB/c mouse model
Environmental Toxicology and Pharmacology, 2013HI-6 is used as an antidote to nerve agents. It can also act as an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α 7 nAChR which is involved in regulating the immune response through macrophages. This experiment investigated the efficacy of HI-6 to regulate the immune response.
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Fate and abiotic stability of HI-6 in aqueous buffers
1987This item was digitized as part of a project to share McGill's intellectual legacy with the public. If you are the copyright holder or a relative of the copyright holder who is deceased, you may request withdrawal by emailing escholarship.library@mcgill.ca.
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HPLC method for determination of oximes HI-6 and trimedoxime in plasma
1995A high-performance liquid chromatographic (HPLC) assay was developed to determine HI-6 and trimedoxime concentrations in small volumes of plasma. The HPLC system comprised a high-pressure pump (model 2150), a multiwavelenght detector (model 2140) set at 284 nm and 295 nm for detection of trimedoxime and HI-6, respectively, and a sample injector ...
Milić, B +2 more
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Stability study of HI-6 dichloride in various anticholinergic formulations
Journal of Chromatography A, 1984N D, Brown +4 more
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