Results 251 to 260 of about 78,665,240 (283)

Bioavailability and disposition kinetics of HI‐6 in Beagle dogs

Biopharmaceutics & Drug Disposition, 1993
AbstractThe absorption and disposition kinetics of HI‐6 were determined in Beagle dogs given single doses (25 mg kg−1) of the drug by the intravenous, intramuscular, and oral routes. Concentrations of the oxime in plasma and urine were measured by HPLC.
J D, Baggot, A, Buckpitt, D, Johnson, P, Brennan, H, Chung   +4 more
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Cardiopulmonary effects of HI-6 treatment in soman intoxication

Journal of Applied Toxicology, 2001
The cardiopulmonary effects of HI-6, together with atropine and soman, were studied in the rat. HI-6 is an effective antidote in acute poisoning with the nerve agent soman. The therapeutic efficiency of HI-6 is still unclear and cannot be explained entirely by the HI-6 reactivating ability of acetylcholinesterase (AChE).
A, Göransson-Nyberg, G, Cassel
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HI-6 Therapy and the acute phase response in the rat

Toxicology, 1996
The propensity of therapeutic doses of HI-6 (50 mg/kg) in combination with atropine sulphate (17 mg/kg), antidotes used to treat organophosphate poisoning, to induce the acute phase response (APR) in the laboratory rat was examined. A single intraperitoneal injection of HI-6, either alone or with atropine, caused a rapid doubling of the plasma ...
S, Ivanović-Matić, G, Poznanović
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Non-reactivating effects of HI-6 on hippocampal neurotransmission

Archives of Toxicology, 1994
Effects of the oxime HI-6, unrelated to reactivation of acetylcholinesterase (AChE), on field potentials in the dentate gyrus of the rat hippocampus following AChE inhibition, were investigated both in vitro and in vivo. In hippocampal slices, AChE inhibition decreased the perforant path evoked population spike amplitude (PSA).
Melchers, B.P.C., Laaken, A.L. van der, Busker, R.W., Bruijnzeel, P.L.B., Helden, H.P.M. van   +4 more
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HI 6 dimethanesulfonate has better dissolution properties than HI 6 dichloride for application in dry/wet autoinjectors

International Journal of Pharmaceutics, 1996
To oppose the rapid onset of cholinergic crisis after poisoning with highly toxic organophosphorus compounds, atropine in combination with a cholinesterase reactivator should be administered as early as possible. Due to its broader antidotal spectrum against nerve agents, the second-generation oxime HI 6 appears suitable to replace the marketed oximes,
Horst Thiermann, Stephan Seidl, Peter Eyer   +2 more
openaire   +1 more source

DFT conformational studies of the HI‐6 molecule

International Journal of Quantum Chemistry, 2005
AbstractA systematic study of the oxime HI‐6 [1‐(2‐hydroxyiminomethyl‐1‐pyridinium)‐1‐(4‐carboxy‐aminopyridinium)dimethyl ether] hydrochloride, which is one of the most promising antidotes against soman intoxication, was carried out using density functional theory with the B3LYP (Becke, Lee, Yang, and Parr) method and the 6‐31+G*, 6‐31+G*, and 6‐31+G**
Gustavo R. Silva, Itamar Borges, Jose D. Figueroa‐Villar   +2 more
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Photostability of antidotal oxime HI‐6, impact on drug development

Drug Testing and Analysis, 2012
HI‐6 exhibits superior efficacy in the therapy of intoxication by different highly toxic organophosphorus nerve agents. Therefore HI‐6 is a promising candidate for the development of new antidotes against nerve agents. For ethical and safety reasons antidotes containing HI‐6 should get marketing authorization.
Reinhard, Bogan, Franz, Worek, Marianne, Koller, Bernd, Klaubert   +3 more
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HI-6 in Man: Efficacy of the Oxime in Poisoning by Organophosphorus Insecticides

Human & Experimental Toxicology, 1991
The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. HI-6 was given four times daily as a single intramuscular injection of 500 mg accompanied by atropine and diazepam therapy. Oxime treatment was started on admission and continued for a minimum of 48 h and a maximum of 7 d.
R, Kusić, D, Jovanović, S, Randjelović, D, Joksović, V, Todorovic, B, Bosković, M, Jokanović, V, Vojvodić   +7 more
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In vitro and in vivo genotoxicity assessment of HI-6 dimethanesulfonate/oxime

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014
Organophosphate compounds, which induce organophosphate poisoning, were originally used as pesticides. But this type of product has also been used as warfare nerve agent like sarin, soman, Russian VX, or tabun. HI-6-dimethanesulfonate is a salt of the oxime HI-6 used in the treatment of nerve-agent poisoning.
Lauren, Nakab, Isabelle, Bardot, Sébastien, Bardot, Sophie, Simar, Daniel, Marzin, Fabrice, Nesslany   +5 more
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HI-6 therapy of soman and tabun poisoning in primates and rodents

Archives of Toxicology, 1989
The bis-pyridinium oxime HI-6, in conjunction with atropine, was found to offer significant protection against multiple LD50 challenges with the organophosphorus compounds soman and tabun. In adult rhesus macaques, the therapeutic administration of HI-6 with atropine and diazepam protected three of four animals from the lethal effects of 5 x LD50 of ...
M G, Hamilton, P M, Lundy
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