Results 251 to 260 of about 258,722 (267)
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A High-Performance Liquid Chromatographic Assay for HI-6 Oxime in Plasma*
Journal of Analytical Toxicology, 1990A high-performance liquid chromatographic (HPLC) assay was developed to determine HI-6 (1-(2-hydroxyiminomethyl-1-pyridinio-3-(4-carbamoyl-1-py ridiniol-2-oxapropane dichloride)) concentrations in small volumes of plasma. A 100-microL plasma sample added to 900 microL of distilled water was microfiltered. Filtrate (200 microL) was injected onto an HPLC
M P, McCluskey +4 more
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In vitro and in vivo genotoxicity assessment of HI-6 dimethanesulfonate/oxime
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014Organophosphate compounds, which induce organophosphate poisoning, were originally used as pesticides. But this type of product has also been used as warfare nerve agent like sarin, soman, Russian VX, or tabun. HI-6-dimethanesulfonate is a salt of the oxime HI-6 used in the treatment of nerve-agent poisoning.
Lauren, Nakab +5 more
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HI-6 therapy of soman and tabun poisoning in primates and rodents
Archives of Toxicology, 1989The bis-pyridinium oxime HI-6, in conjunction with atropine, was found to offer significant protection against multiple LD50 challenges with the organophosphorus compounds soman and tabun. In adult rhesus macaques, the therapeutic administration of HI-6 with atropine and diazepam protected three of four animals from the lethal effects of 5 x LD50 of ...
M G, Hamilton, P M, Lundy
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Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime
Biochemical Pharmacology, 1986Acetylcholinesterase was purified from human caudate nucleus and skeletal muscle. The enzyme preparations were used to study aging and reactivation by HI-6 and obidoxime after inhibition by soman and its isomers. HI-6 was found to be the most potent reactivator.
G, Puu, E, Artursson, G, Bucht
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HI-6 modulates immunization efficacy in a BALB/c mouse model
Environmental Toxicology and Pharmacology, 2013HI-6 is used as an antidote to nerve agents. It can also act as an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α 7 nAChR which is involved in regulating the immune response through macrophages. This experiment investigated the efficacy of HI-6 to regulate the immune response.
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Toxicology, 2016
Despite extensive research for decades no effective broad-spectrum oxime for the treatment of poisoning by a broad range of nerve agents is available. Previous in vitro and in vivo data indicate that the combination of in service oximes could be beneficial.
Franz, Worek +3 more
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Despite extensive research for decades no effective broad-spectrum oxime for the treatment of poisoning by a broad range of nerve agents is available. Previous in vitro and in vivo data indicate that the combination of in service oximes could be beneficial.
Franz, Worek +3 more
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An optical biosensor based on His 6 -OPH for organophosphate detection
SPIE Proceedings, 2011In this work we describe a method for immobilizing the hexahistidine-modified OPH (His 6 -OPH) enzyme via sol-gel technology in a porous material while retaining its catalytic activity. The potential use of each bio-sensing material was checked by quantifying the enzymatic properties, such as the relative activity of the immobilized enzyme, its ...
Nina Frančič +4 more
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Effect of endogenous carboxylesterase on HI-6 protection against soman toxicity.
The Journal of Pharmacology and Experimental Therapeutics, 1990Species variation in oxime protection against soman was examined in mice and guinea pigs with the bis-pyridinium oxime HI-6. HI-6, an effective reactivator of soman-inhibited acetylcholinesterase, produced greater maximal protection against soman in mice than in guinea pigs, although there was no species difference in acetylcholinesterase reactivation.
D M, Maxwell, I, Koplovitz
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HI-6 is Incapable of Reactivating Tabun-Phosphonylated Human Acetylcholinesterase
1995A 1:10 (w/v) ratio of human brain homogenate in phosphate buffer (67 mmol-L−1, pH 7.2) was respectively added to sarin or VX (50 nmol-L−1), tabun or soman (100 nmol-L−1). A 1:60 (v/v) ratio of human RBC suspension in isotonic phosphate buffer (pH 7.2) was added to nerve agents (all 87 nmol-L−1).
Chunyuan Luo, Jinsheng Yang, Manji Sun
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Chemical Stability of the Hagedorn Oximes HGG‐12 and HI‐6
Archiv der Pharmazie, 1985AbstractThe chemical stability of the soman antidotes HGG‐12 and HI‐6 was studied over the pH range 2–9 at various temperatures. Maximum stability for both oximes was found at pH 2. From Arrhenius plots the predicted shelf life (10% decomposition) was 2.6 years at 25° C and 60 years at 4 °C for both oximes.
Peter Eyer, Winfried Hell
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