Results 241 to 250 of about 258,722 (267)

Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys

Toxicology and Applied Pharmacology, 1992
The therapeutic efficacy of the oxime HI-6 against intoxication with the irreversible cholinesterase (ChE) inhibitor soman was tested in marmoset monkeys. Five out of six marmosets, intoxicated with 5 x LD50 soman and treated immediately with diazepam (0.2 mg.kg-1 iv) and 15 sec later with atropine (0.5 mg.kg-1 im) and HI-6 (50 mg.kg-1 im), survived ...
H P, van Helden, H J, van der Wiel, J, de Lange, R W, Busker, B P, Melchers, O L, Wolthuis   +5 more
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Neurobehavioral effects of the pyridinium aldoxime cholinesterase reactivator HI-6

Neurotoxicology and Teratology, 1990
A series of neurobehavioral testing procedures was used to evaluate the behavioral effects of the pyridinium aldoxime cholinesterase reactivator HI-6 in male Sprague-Dawley rats. These procedures were fixed-ratio (FR) responding, shuttle-box conditioned avoidance response (CAR), conditioned taste aversion (CTA), drinking behavior, open-field ...
W F, Liu, J H, Shih
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HI-6 Therapy and the acute phase response in the rat

Toxicology, 1996
The propensity of therapeutic doses of HI-6 (50 mg/kg) in combination with atropine sulphate (17 mg/kg), antidotes used to treat organophosphate poisoning, to induce the acute phase response (APR) in the laboratory rat was examined. A single intraperitoneal injection of HI-6, either alone or with atropine, caused a rapid doubling of the plasma ...
S, Ivanović-Matić, G, Poznanović
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Trimedoxime and HI‐6: Kinetic Comparison after Intravenous Administration to Mice

Pharmacology & Toxicology, 1996
Abstract: The intravenous pharmacokinetics of the oximes HI‐6 (pyridinium‐1‐(((4‐carbamoi 1‐pyridinio)metoxy)rnethyl)‐2‐(hydroxyiminomethyl)dichloride monohydrate), (132.54 μmol/kg) and trimedoxime (1,1′‐(1,3′‐propanedyl)bis((4‐hydroxyimino) methyl)‐pyridinium dibromide), (55,98 μmol/kg) in mice was investigated. The concentrations of oximes in plasma
B, Milic, M, Maksimovic, M, Nedelijkovic
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Cholinergic Effects of HI-6 in Soman Poisoning

1986
During the past decade considerable advances have been made in the development of therapeutic antidotes against organophosphorus cholinesterase (ChE) inhibitors. Poisoning with most organophosphorus anticholinesterases (AntiChE) is treatable with a combination of an antimuscarinic compound, such as atropine sulfate (ATS), and an oxime, such as ...
T.-M. Shih, C. E. Whalley, J. J. Valdes, P. M. Lundy, P. A. Lockwood   +4 more
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The acetylcholinesterase reactivator HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxylmethyl]-2-[(hydroxyimino)methyl]-pyridinium dichloride): a comparative study of HI-6 samples from various sources

Archives of Toxicology, 1988
A comparison of the chemical purity, toxicology and potency of HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2- [(hydroxyimino)methyl]-pyridinium dichloride) obtained from various sources (Canada, Israel, Yugoslavia, The Netherlands, United Kingdom) was performed.
J G, Clement, P A, Lockwood, H G, Thompson   +2 more
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Study on the stability of the oxime HI 6 in aqueous solution

Archives of Toxicology, 1988
HI 6 (Pyridinium, 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydro xyimino) methyl]-dichloride is an effective antidote against poisoning with extremely toxic organophosphates. Because of conflicting reports on the stability of HI 6 in aqueous solutions, we studied the factors influencing its stability. HI 6 has been shown to be most stable in
P, Eyer, I, Hagedorn, B, Ladstetter
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Application of interspecies scaling to the bispyridinium oxime HI-6

American Journal of Veterinary Research, 1994
Summary Disposition kinetic variables of HI-6, a bispyridinium oxime, have been determined in mice, rats, rabbits, Rhesus monkeys, Beagles, sheep, and human beings. The drug has a short half-life, small apparent volume of distribution and high body clearance in these species, and is eliminated mainly by renal excretion.
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Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP

Biochemical and Biophysical Research Communications, 2006
We used mouse recombinant wild-type acetylcholinesterase (AChE; EC 3.1.1.7), butyrylcholinesterase (BChE; EC 3.1.1.8), and AChE mutants with mutations (Y337A, F295L, F297I, Y72N, Y124Q, and W286A) that resemble residues found at structurally equivalent positions in BChE, to find the basis for divergence between AChE and BChE in following reactions ...
Kovarik, Zrinka, Ciban, Nikolina, Radić, Zoran, Simeon-Rudolf, Vera, Taylor, Palmer   +4 more
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Studies on the decomposition of the oxime HI 6 in aqueous solution

Archives of Toxicology, 1986
HI 6 has been shown to be efficacious in soman intoxication of laboratory animals by reactivation of acetylcholinesterase. To assess possible risks involved in the administration of HI 6 its degradation products were analyzed at pH 2.0, 4.0, 7.4, and 9.0.
P, Eyer, W, Hell, A, Kawan, H, Klehr
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