Results 241 to 250 of about 78,665,240 (283)
In vivo distribution of organophosphate antidotes: Autoradiography of [14C]HI-6 in the rat
Toxicology and Applied Pharmacology, 1988 In order to visualize the distribution of HI-6 in the rat after iv administration, autoradiographic experiments were carried out with [14C]HI-6, labeled at the carbon of the carboxamide moiety. Autoradiography clearly confirms penetration of HI-6 into the central nervous system.
Ligtenstein, D.A. +2 more
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Drug and Chemical Toxicology, 2011
The ability of two combinations of oximes (HI-6+trimedoxime, HI-6+K203) to reduce soman-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of the oxime HI-6 alone, using a functional observational battery. Soman-induced neurotoxicity and the neuroprotective effects of HI-6 alone and HI-6 combined with trimedoxime
Jiri, Kassa +2 more
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The ability of two combinations of oximes (HI-6+trimedoxime, HI-6+K203) to reduce soman-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of the oxime HI-6 alone, using a functional observational battery. Soman-induced neurotoxicity and the neuroprotective effects of HI-6 alone and HI-6 combined with trimedoxime
Jiri, Kassa +2 more
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The pharmacokinetics of HI‐6 in beagle dogs
Biopharmaceutics & Drug Disposition, 1983AbstractThe pharmacokinetics of HI‐6 were studied following intravenous administration to beagle dogs (n = 7). The bioavailability of two different strength intramuscularly administered doses was also determined in the same animals. After a 20 mg kg−1 intravenous dose, the mean (±S.D.) initial HI‐6 plasma concentration was 93·1 ± 10·μg ml−1.
K J, Simons, C J, Briggs
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Genetic toxicology assessment of HI-6 dichloride
Environmental and Molecular Mutagenesis, 1996The oxime HI-6 dichloride [1-(2 hydroxyiminomethyl -1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride monohydrate] has shown to be a potent reactivator of cholinesterase activity and may have efficacy for the treatment of organophosphate intoxication [SIPRI, 1976; Schenk et al.; Arch Toxicol 36:71-81, 1976]. As part of a preclinical safety
D, Putman +4 more
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Drug Development and Industrial Pharmacy, 1995
AbstractA stability-indicating reversed-phase high performance liquid chromatographic method was developed for the detection of HI-6 and its degradation products under accelerated degradation conditions. The degradation kinetics of HI-6 in aqueous solution over a pH range of 1.14 to 5.54 and its stability in propylene glycol or polyethylene glycol 400 ...
Da-Peng Wang, Jeng-Dong Lee, Rong-An Lin
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AbstractA stability-indicating reversed-phase high performance liquid chromatographic method was developed for the detection of HI-6 and its degradation products under accelerated degradation conditions. The degradation kinetics of HI-6 in aqueous solution over a pH range of 1.14 to 5.54 and its stability in propylene glycol or polyethylene glycol 400 ...
Da-Peng Wang, Jeng-Dong Lee, Rong-An Lin
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Archives of Toxicology, 2002
The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory.
S, Krummer +3 more
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The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory.
S, Krummer +3 more
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Pharmacology of HI-6, an H-series oxime
Canadian Journal of Physiology and Pharmacology, 1989HI-6 is an oxime experimentally developed for reactivation of previously untreatable soman-phosphorylated acetylcholinesterase. It has been shown to be effective in restoring acetylcholinesterase activity after poisoning with other "nerve agents" namely VX and sarin; however, its antidotal qualities for the treatment of organophosphorus pesticide ...
C G, Rousseaux, A K, Dua
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Studies on the decomposition of the oxime HI 6 in aqueous solution
Archives of Toxicology, 1986HI 6 has been shown to be efficacious in soman intoxication of laboratory animals by reactivation of acetylcholinesterase. To assess possible risks involved in the administration of HI 6 its degradation products were analyzed at pH 2.0, 4.0, 7.4, and 9.0.
P, Eyer, W, Hell, A, Kawan, H, Klehr
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Study on the stability of the oxime HI 6 in aqueous solution
Archives of Toxicology, 1988HI 6 (Pyridinium, 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydro xyimino) methyl]-dichloride is an effective antidote against poisoning with extremely toxic organophosphates. Because of conflicting reports on the stability of HI 6 in aqueous solutions, we studied the factors influencing its stability. HI 6 has been shown to be most stable in
P, Eyer, I, Hagedorn, B, Ladstetter
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