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HI-6 in Man: Efficacy of the Oxime in Poisoning by Organophosphorus Insecticides
Human & Experimental Toxicology, 1991The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. HI-6 was given four times daily as a single intramuscular injection of 500 mg accompanied by atropine and diazepam therapy. Oxime treatment was started on admission and continued for a minimum of 48 h and a maximum of 7 d.
R, Kusić +7 more
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Histopathological Changes in Gastrocnemius Muscles of Rabbits Injected with HI-6 in Saline
Drug and Chemical Toxicology, 1990The gastrocnemius muscles of rabbits were injected with HI-6 in saline. Macroscopic and histopathological examinations of injection sites and regional lymph nodes revealed that HI-6 in saline produced muscle necrosis. Macroscopic examinations of muscles injected with a low dose of HI-6 (50 mg/kg) showed no lesions on Day 7.
C E, Connolley-Mendoza +2 more
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Toxicology Letters, 2013
Pigs were administered intramuscularly molar equivalents of HI-6 salts (HI-6 dichloride 10.71 mg/kg and HI-6 DMS 13.59 mg/kg) either with or without hyaluronidase (60 U/kg). Hyaluronidase is supposed to increase tissue permeability and diminishes discomfort caused by the intramuscular injection.
Jana Zdarova, Karasova +4 more
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Pigs were administered intramuscularly molar equivalents of HI-6 salts (HI-6 dichloride 10.71 mg/kg and HI-6 DMS 13.59 mg/kg) either with or without hyaluronidase (60 U/kg). Hyaluronidase is supposed to increase tissue permeability and diminishes discomfort caused by the intramuscular injection.
Jana Zdarova, Karasova +4 more
openaire +2 more sources
Stability study of HI-6 dichloride in various anticholinergic formulations
Journal of Chromatography A, 1984N D, Brown +4 more
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Inhibicija acetilkolinesteraze i butirilkolinesteraze piridinijevim oksimima 2- PAM i HI-6
2005Piridin-2-aldoksim-N-metilklorid (2-PAM) i 1- (2-hidroksiiminometil-1-piridinio)-3-(4- karbamoil-1-piridinio)-2-oksapropan diklorid (HI-6) su reverzibilni inhibitori acetilkolinesteraze (EC 3.1.1.7 ; AChE) i butirilkolinesteraze (EC 3.1.1.8 ; BChE).
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