Results 261 to 270 of about 19,695,084 (324)

Photostability of antidotal oxime HI‐6, impact on drug development

Drug Testing and Analysis, 2012
HI‐6 exhibits superior efficacy in the therapy of intoxication by different highly toxic organophosphorus nerve agents. Therefore HI‐6 is a promising candidate for the development of new antidotes against nerve agents. For ethical and safety reasons antidotes containing HI‐6 should get marketing authorization.
Reinhard, Bogan, Franz, Worek, Marianne, Koller, Bernd, Klaubert   +3 more
openaire   +3 more sources

HI-6 modulates immunization efficacy in a BALB/c mouse model

Environmental Toxicology and Pharmacology, 2013
HI-6 is used as an antidote to nerve agents. It can also act as an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α 7 nAChR which is involved in regulating the immune response through macrophages. This experiment investigated the efficacy of HI-6 to regulate the immune response.
M. Pohanka
openaire   +3 more sources

HI-6 in Man: Efficacy of the Oxime in Poisoning by Organophosphorus Insecticides

Human & Experimental Toxicology, 1991
The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. HI-6 was given four times daily as a single intramuscular injection of 500 mg accompanied by atropine and diazepam therapy. Oxime treatment was started on admission and continued for a minimum of 48 h and a maximum of 7 d.
R, Kusić, D, Jovanović, S, Randjelović, D, Joksović, V, Todorovic, B, Bosković, M, Jokanović, V, Vojvodić   +7 more
openaire   +3 more sources

Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime

Biochemical Pharmacology, 1986
Acetylcholinesterase was purified from human caudate nucleus and skeletal muscle. The enzyme preparations were used to study aging and reactivation by HI-6 and obidoxime after inhibition by soman and its isomers. HI-6 was found to be the most potent reactivator.
G, Puu, E, Artursson, G, Bucht
openaire   +3 more sources

Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6.

Chemical Research in Toxicology, 2021
The recent use of organophosphate nerve agents in Syria, Malaysia, Russia, and the United Kingdom has reinforced the potential threat of their intentional release.
J. McGuire, S. Bester, M. Guelta, J. Cheung, C. Langley, M. Winemiller, Sue Y. Bae, Vanessa L. Funk, J. Myslinski, S. Pegan, J. Height   +10 more
semanticscholar   +1 more source

Genetic toxicology assessment of HI-6 dichloride

Environmental and Molecular Mutagenesis, 1996
The oxime HI-6 dichloride [1-(2 hydroxyiminomethyl -1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride monohydrate] has shown to be a potent reactivator of cholinesterase activity and may have efficacy for the treatment of organophosphate intoxication [SIPRI, 1976; Schenk et al.; Arch Toxicol 36:71-81, 1976]. As part of a preclinical safety
D, Putman, R H, San, C A, Bigger, B S, Levine, D, Jacobson-Kram   +4 more
openaire   +2 more sources

Stability of HI-6 in Solution

Drug Development and Industrial Pharmacy, 1995
AbstractA stability-indicating reversed-phase high performance liquid chromatographic method was developed for the detection of HI-6 and its degradation products under accelerated degradation conditions. The degradation kinetics of HI-6 in aqueous solution over a pH range of 1.14 to 5.54 and its stability in propylene glycol or polyethylene glycol 400 ...
Da-Peng Wang, Jeng-Dong Lee, Rong-An Lin
openaire   +1 more source

Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonate

Archives of Toxicology, 2002
The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory.
S, Krummer, H, Thiermann, F, Worek, P, Eyer   +3 more
openaire   +2 more sources

Pharmacology of HI-6, an H-series oxime

Canadian Journal of Physiology and Pharmacology, 1989
HI-6 is an oxime experimentally developed for reactivation of previously untreatable soman-phosphorylated acetylcholinesterase. It has been shown to be effective in restoring acetylcholinesterase activity after poisoning with other "nerve agents" namely VX and sarin; however, its antidotal qualities for the treatment of organophosphorus pesticide ...
C G, Rousseaux, A K, Dua
openaire   +2 more sources

The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study.

Toxicology Letters, 2017
Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes.
F. Worek, H. Thiermann, T. Wille
semanticscholar   +1 more source