Results 41 to 50 of about 254,858 (270)
Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice
Acta Medica, 2004 The toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice.
Lucie Bartošová +3 more
doaj +1 more source
HI-6 pharmacokinetics in rabbits after intravenous and intramuscular administration
Journal of Pharmacy and Pharmacology, 1992 Abstract The pharmacokinetics of HI-6 ((4-carboxamidopyridinium (1) methyl)-(2′-hydroxyiminomethyl-pyridinium (1′) methyl) ether dichloride) have been studied in rabbits receiving an intramuscular (50 μg kg−1) or intravenous (12·5 μg kg−1) dose.
B J, Lukey +3 more
openaire +2 more sources
Consecutive primes and Legendre symbols
, 2019 Let $m$ be any positive integer and let $\delta_1,\delta_2\in\{1,-1\}$. We show that for some constanst $C_m>0$ there are infinitely many integers $n>1$ with $p_{n+m}-p_n\le C_m$ such that $$\left(\frac{p_{n+i}}{p_{n+j}}\right)=\delta_1\ \quad\text{and}\
Pan, Hao, Sun, Zhi-Wei
core +1 more source
Gauss-Bonnet Cosmology Unifying Late and Early-time Acceleration Eras with Intermediate Eras
, 2016 In this paper we demonstrate that with vacuum $F(G)$ gravity it is possible to describe the unification of late and early-time acceleration eras with the radiation and matter domination era.
Oikonomou, V. K.
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2022 We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (OP ...
Jeffrey S. Thinschmidt +4 more
doaj +1 more source
On the number of perfect lattices [PDF]
, 2017 We show that the number $p\_d$ of non-similar perfect $d$-dimensional lattices satisfies eventually the inequalities$e^{d^{1-\epsilon}}
Bacher, Roland
core +3 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Reflection Groups and Differential Forms
, 2007 We study differential forms invariant under a finite reflection group over a field of arbitrary characteristic. In particular, we prove an analogue of Saito's freeness criterion for invariant differential 1-forms.
Hartmann, Julia, Shepler, Anne V.
core +2 more sources