Results 31 to 40 of about 72,882 (259)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Research on urban comprehensive energy planning system based on hierarchical framework and CAS theory

Energy Reports, 2022
The innovation of the city’s integrated energy system has become the key to China’s realization of “carbon peaks by 2030 and carbon neutrality by 2060”.
Hao Huang, Qi-fen Li, Yong-wen Yang, Li-ting Zhang, Zi-wen Dong   +4 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Deep Hierarchical Planning from Pixels

Advances in Neural Information Processing Systems 35, 2022
Website: https://danijar.com ...
Danijar Hafner, Kuang-Huei Lee, Ian Fischer, Pieter Abbeel   +3 more
openaire   +3 more sources

Hierarchical DDPG for Manipulator Motion Planning in Dynamic Environments

AI, 2022
In this paper, a hierarchical reinforcement learning (HRL) architecture, namely a “Hierarchical Deep Deterministic Policy Gradient (HDDPG)” has been proposed and studied.
Dugan Um, Prasad Nethala, Hocheol Shin
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Simple Hierarchical Planning with Diffusion

CoRR
Diffusion-based generative methods have proven effective in modeling trajectories with offline datasets. However, they often face computational challenges and can falter in generalization, especially in capturing temporal abstractions for long-horizon tasks.
Chang Chen, Fei Deng 0001, Kenji Kawaguchi, Caglar Gulcehre, Sungjin Ahn   +4 more
openaire   +3 more sources

Using Earley Parser for Verification of Totally Ordered Hierarchical Plans

Proceedings of the International Florida Artificial Intelligence Research Society Conference
Hierarchical planning extends classical planning by capturing the hierarchical structure of tasks via decomposition of tasks to subtasks. Hierarchical plan verification is the problem of determining whether a given plan is valid according to that ...
Kristýna Pantůčková, Simona Ondrčková, Roman Barták   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source