Microbiology Spectrum, 2022 Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the swine industry worldwide since the late 1980s.
Yu Pang +7 more
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Cholesterol and HIF-1α: Dangerous Liaisons in Atherosclerosis
Frontiers in Immunology, 2022 HIF-1α exerts both detrimental and beneficial actions in atherosclerosis. While there is evidence that HIF-1α could be pro-atherogenic within the atheromatous plaque, experimental models of atherosclerosis suggest a more complex role that depends on the ...
Charles Thomas +10 more
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HIF-1α inhibition reduces nasal inflammation in a murine allergic rhinitis model. [PDF]
PLoS ONE, 2012 BACKGROUND: Hypoxia-inducible factor 1α (HIF-1α) is an important regulator of immune and inflammatory responses. We hypothesized that nasal allergic inflammation is attenuated by HIF-1α inhibition and strengthened by HIF-1α stabilization.
Han Zhou +4 more
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Hypoxia stimulates neural stem cell proliferation by increasing HIF"‘1α expression and activating Wnt/β-catenin signaling [PDF]
Cellular and Molecular Biology, 2017 Evidence indicates that after brain injury, neurogenesis is enhanced in regions such as hippocampus, striatum, and cortex. To study the role of hypoxia-inducible factor-1 (HIF"‘1α) and Wnt signaling in cerebral ischemia/hypoxia-induced proliferation of neural stem cells (NSCs), we investigated the proliferation of NSCs, expression of HIF"‘1α, and ...
C, Qi +6 more
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Synergistic inhibition of Wnt pathway by HIF-1α and osteoblast-specific transcription factor osterix (Osx) in osteoblasts. [PDF]
PLoS ONE, 2012 Osterix (Osx) is an osteoblast-specific transcription factor required for osteoblast differentiation. Inhibition of Wnt pathway by Osx highlights the potential for feedback control mechanisms involved in bone formation.
Dafu Chen +7 more
doaj +1 more source
Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma
Cellular and Molecular Biology, 2020 The radiation sensitivity of tumor cells is closely related to tumor cell hypoxia. Hypoxia-inducible factor-1α (HIF-1α) is considered a key transcription factor which regulates the sensitivity of hypoxic tumor cells to radiotherapy. On the other hand, some studies have shown that gold nanomaterials improve radiation sensitivity.
Gang, Xu +7 more
openaire +3 more sources
Insulin regulates hypoxia-inducible factor-1α transcription by reactive oxygen species sensitive activation of Sp1 in 3T3-L1 preadipocyte. [PDF]
PLoS ONE, 2013 Oxygen sensing transcription factor HIF-1 is activated due to accumulation of regulatory subunit HIF-1α by posttranslational stability mechanism during hypoxia or by several other stimuli even in normoxia.
Sudipta Biswas +4 more
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Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice [PDF]
Frontiers in Aging Neuroscience, 2015 The widely recognized neuroprotective effect of iron chelators is contributed by their ability to prevent reactive oxygen species (ROS) generation via the Fenton reaction, which sequesters redox-active Fe. An additional neuroprotective mechanism of iron-chelating compounds is to regulate the transcriptional activator hypoxia-inducible factor 1α (HIF-1α)
Guo, Chuang +7 more
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HIF-1α inhibits Wnt signaling pathway by activating Sost expression in osteoblasts. [PDF]
PLoS ONE, 2013 The nature of the cellular and molecular mechanisms for the transition of avascular cartilage replacement with bone during endochondral ossification remains poorly understood. One of the driving forces is hypoxia.
Dafu Chen +7 more
doaj +1 more source
Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma. [PDF]
PLoS Pathogens, 2017 Primary effusion lymphoma (PEL) is an aggressive B-cell lymphoma with poor prognosis caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Previous studies have revealed that HIF-1α, which mediates much of the cellular response to hypoxia, plays an ...
Prabha Shrestha +5 more
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