Results 1 to 10 of about 221,083 (372)
The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia
Journal of Hematology & Oncology, 2021 Hypoxia inducible factor-1α (HIF-1α) up-regulates the expression of programmed death ligand-1 (PD-L1) in some extracranial malignancies. However, whether it could increase PD-L1 expression in intracranial tumor is still unknown.
Xing-chen Ding +12 more
doaj +2 more sources
Microbiology Spectrum, 2022 Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the swine industry worldwide since the late 1980s.
Yu Pang +7 more
doaj +1 more source
Journal of Nanobiotechnology, 2023 Background Stabilization and increased activity of hypoxia-inducible factor 1-α (HIF-1α) can directly increase cancellous bone formation and play an essential role in bone modeling and remodeling.
Shuang Song +9 more
semanticscholar +1 more source
Cholesterol and HIF-1α: Dangerous Liaisons in Atherosclerosis
Frontiers in Immunology, 2022 HIF-1α exerts both detrimental and beneficial actions in atherosclerosis. While there is evidence that HIF-1α could be pro-atherogenic within the atheromatous plaque, experimental models of atherosclerosis suggest a more complex role that depends on the ...
Charles Thomas +10 more
doaj +1 more source
Journal of experimental & clinical cancer research : CR, 2021 Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have not yielded success.
S. Dong +12 more
semanticscholar +1 more source
HIF-1α inhibition reduces nasal inflammation in a murine allergic rhinitis model. [PDF]
PLoS ONE, 2012 BACKGROUND: Hypoxia-inducible factor 1α (HIF-1α) is an important regulator of immune and inflammatory responses. We hypothesized that nasal allergic inflammation is attenuated by HIF-1α inhibition and strengthened by HIF-1α stabilization.
Han Zhou +4 more
doaj +1 more source
Cells, 2022 In the physiological condition, the skeletal system’s bone resorption and formation are in dynamic balance, called bone homeostasis. However, bone homeostasis is destroyed under pathological conditions, leading to the occurrence of bone metabolism ...
Wei Chen +5 more
semanticscholar +1 more source
Synergistic inhibition of Wnt pathway by HIF-1α and osteoblast-specific transcription factor osterix (Osx) in osteoblasts. [PDF]
PLoS ONE, 2012 Osterix (Osx) is an osteoblast-specific transcription factor required for osteoblast differentiation. Inhibition of Wnt pathway by Osx highlights the potential for feedback control mechanisms involved in bone formation.
Dafu Chen +7 more
doaj +1 more source
Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice
Frontiers in Endocrinology, 2021 Background Ferroptosis is a recently identified iron-dependent form of cell death as a result of increased reactive oxygen species (ROS) and lipid peroxidation.
Xiaomeng Feng +6 more
semanticscholar +1 more source
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19
Signal Transduction and Targeted Therapy, 2021 Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial determinant in COVID-19 prognosis. Understanding the mechanism underlying the SARS-
Mingfu Tian +17 more
semanticscholar +1 more source