HIF-1α mediates isoflurane-induced vascular protection in subarachnoid hemorrhage [PDF]
Annals of Clinical and Translational Neurology, 2015 OBJECTIVE: Outcome after aneurysmal subarachnoid hemorrhage (SAH) depends critically on delayed cerebral ischemia (DCI) – a process driven primarily by vascular events including cerebral vasospasm, microvessel thrombosis, and microvascular dysfunction ...
Gidday, Jeffrey M +6 more
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Trophoblast-Specific Expression of Hif-1α Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction [PDF]
Scientific Reports, 2019 The placenta is an essential organ that is formed during pregnancy and its proper development is critical for embryonic survival. While several animal models have been shown to exhibit some of the pathological effects present in human preeclampsia, these
Renee E. Albers +8 more
semanticscholar +4 more sources
Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism [PDF]
Mucosal Immunology, 2021 Group 3 innate lymphoid cells (ILC3) have a prominent role in the maintenance of intestine mucosa homeostasis. The hypoxia-inducible factor (HIF) is an important modulator of immune cell activation and a key mechanism for cellular adaptation to oxygen deprivation. However, its role on ILC3 is not well known. In this study, we investigated how a hypoxic
P M M M Vieira +11 more
openaire +4 more sources
Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1α-mediated transcriptional regulation of their transporters [PDF]
Journal of Biological Chemistry, 2022 Hypoxia exerts profound effects on cell physiology, but its effect on colonic uptake of the microbiota-generated forms of vitamin B1 (i.e., thiamin pyrophosphate [TPP] and free thiamine) has not been described. Here, we used human colonic epithelial NCM460 cells and human differentiated colonoid monolayers as in vitro and ex vivo models, respectively ...
Sabui, Subrata +5 more
openaire +4 more sources
Correlation of VEGF and HIF-1α in breast carcinoma (an immunohistochemical study)
IP Journal of Diagnostic Pathology and Oncology, 2020 Introduction: By 2030 the incidence of breast cancer in India will increase to around 200,000 per year. During tumor growth, angiogenesis is induced by many stimuli. Reduced oxygen stimulates hypoxia induced factor 1 alpha (HIF-1?), activating proangiogenic cytokines i.e. vascular endothelial growth factor (VEGF).
Manisha Sharma +4 more
openaire +3 more sources
Hypoxia stimulates neural stem cell proliferation by increasing HIF"‘1α expression and activating Wnt/β-catenin signaling [PDF]
Cellular and Molecular Biology, 2017 Evidence indicates that after brain injury, neurogenesis is enhanced in regions such as hippocampus, striatum, and cortex. To study the role of hypoxia-inducible factor-1 (HIF"‘1α) and Wnt signaling in cerebral ischemia/hypoxia-induced proliferation of neural stem cells (NSCs), we investigated the proliferation of NSCs, expression of HIF"‘1α, and ...
Chen Xudong +6 more
openaire +2 more sources
Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma
Cellular and Molecular Biology, 2020 The radiation sensitivity of tumor cells is closely related to tumor cell hypoxia. Hypoxia-inducible factor-1α (HIF-1α) is considered a key transcription factor which regulates the sensitivity of hypoxic tumor cells to radiotherapy. On the other hand, some studies have shown that gold nanomaterials improve radiation sensitivity.
Rencui Quan +7 more
openaire +4 more sources
HIF-1α in the heart: Remodeling nucleotide metabolism [PDF]
Journal of Molecular and Cellular Cardiology, 2015 These studies have examined the effect of hypoxia inducible factor 1α (HIF-1α) on nucleotide metabolism in the ischemic heart using a genetic mouse model with heart-specific and regulated expression of a stable form of HIF-1α. We find that AMP deaminase (AMPD), the entry point of the purine nucleotide cycle (PNC), is induced by HIF-1α at the level of ...
Wu, Joe +6 more
openaire +4 more sources
Insulin regulates hypoxia-inducible factor-1α transcription by reactive oxygen species sensitive activation of Sp1 in 3T3-L1 preadipocyte. [PDF]
PLoS ONE, 2013 Oxygen sensing transcription factor HIF-1 is activated due to accumulation of regulatory subunit HIF-1α by posttranslational stability mechanism during hypoxia or by several other stimuli even in normoxia.
Sudipta Biswas +4 more
doaj +1 more source
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
Nature Communications, 2021 Impaired wound healing and ulcer complications are a leading cause of death in diabetic patients. In this study, we report the design and synthesis of a cyclometalated iridium(III) metal complex 1a as a stabilizer of hypoxia-inducible factor-1α (HIF-1α).
Guodong Li +11 more
semanticscholar +1 more source