Results 21 to 30 of about 135,194 (207)

Correlation of VEGF and HIF-1α in breast carcinoma (an immunohistochemical study)

IP Journal of Diagnostic Pathology and Oncology, 2020
Introduction: By 2030 the incidence of breast cancer in India will increase to around 200,000 per year. During tumor growth, angiogenesis is induced by many stimuli. Reduced oxygen stimulates hypoxia induced factor 1 alpha (HIF-1?), activating proangiogenic cytokines i.e. vascular endothelial growth factor (VEGF).
openaire   +2 more sources

Studying the C1772T polymorphism of Hif-1α and TGF-β3 IVS5+104 A/G polymorphism in children with congenital non-syndromic neural tube defects and their mothers

Cellular and Molecular Biology, 2018
Prevalence of neural tube defect (NTD) has reduced after folic acid intake. However; which mechanisms are effective in NTD are not known exactly. In this study; due to the possible effects on hypoxic pathway and embryonic development, particularly on extracellular matrix components, Hif-1α Pro582Ser and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms were ...
Yıldırım, İbrahim Halil, Koçak, Nadir   +1 more
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Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay [PDF]

, 2014
The molecular mechanisms by which glioblastoma multiforme (GBM) refracts and becomes resistant to radiotherapy treatment remains largely unknown. This radioresistance is partly due to the presence of hypoxic regions, which are frequently found in GBM ...
Cerasani, Manuela, Ciccarelli, Carmela, Di Cesare, Ernesto, Di Genova, Daniela, Festuccia, Claudio, Ficorella, Corrado, Fratticci, Amato, Gravina, Giovanni Luca, Mancini, Marta, Marampon, Francesco, Popov, Vladimir M, Zani, Bianca Maria   +11 more
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Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets

Cell Transplantation, 2013
A high proportion of β-cells die within days of islet transplantation. Reports suggest that induction of hypoxia-inducible factor-1α (HIF-1α) predicts adverse transplant outcomes.
Rebecca A. Stokes, Kim Cheng, Natasha Deters, Sue Mei Lau, Wayne J. Hawthorne, Philip J. O'connell, Jessica Stolp, Shane Grey, Thomas Loudovaris, Thomas W. Kay, Helen E. Thomas, Frank J. Gonzalez, Jenny E. Gunton   +12 more
doaj   +1 more source

Emerging Roles Of hsa-circ-0046600 Targeting The miR-640/HIF-1α Signalling Pathway In The Progression Of HCC.

OncoTargets and therapy, 2019
Circular RNAs (circRNAs) play important roles in the development and progression of various human cancers. hsa-circ-0046600 is a circRNA of unknown function. The purpose of this study was to investigate the biological function of hsa-circ-0046600 in hepatocellular carcinoma (HCC) and elucidate the possible molecular mechanisms of this circRNA.GSE97332,
Zhai,Zhensheng, Fu,Qiang, Liu,Chuanjiang, Zhang,Xu, Jia,Pengchong, Xia,Peng, Liu,Pan, Liao,Shixiu, Qin,Tao, Zhang,Hongwei   +9 more
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An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes. [PDF]

, 2013
BACKGROUND: Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are heterogeneous with respect to biological behaviour and prognosis. As angiogenesis is a renowned pathogenic hallmark as well as a therapeutic target, we aimed to investigate the ...
A Couvelard, A Giatromanolaki, A Rinke, AM Marion-Audibert, AT Dimou, B Terris, D Hanahan, D J Pinato, D O’Toole, DC Metz, DJ Pinato, DJ Pinato, E Raymond, EP Hui, F Panzuto, G Kloppel, HS Kim, I Albrecht, IM Modlin, J LeCouter, J Strosberg, J Zhang, JC Yao, JT Chi, JY Scoazec, K Hirabayashi, K Meeran, K Villaume, M Dal Monte, M Perigny, M Ruscica, MA Maynard, N Martin, N Ngo, P Kuiper, R Dina, R Katoh, R Mentlein, R Ramachandran, R Sharma, S Ezziddin, S T K Toussi, T M Tan, VD Corleto, Y Arvidsson, Y Seo, Y Takahashi, YC Patel   +47 more
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Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]

, 2014
The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Bremm, Anja, Komander, David, Mader, Julia, Moniz, Sonia, Rocha, Sonia   +4 more
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Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner [PDF]

, 2018
17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain ...
Albrecht, Marjorie, Frump, Andrea L., Lahm, Tim, Petrache, Irina, Selej, Mona, Wood, Jordan A., Yakubov, Bakhtiyor   +6 more
core   +1 more source

Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

Hepatology, 2016
Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role of tissue inhibitor of metalloproteinases (TIMP) 2 in the context of ...
Chan, Lo Kong, Lo, Regina Cheuk Lam, Lee, Joyce Man Fong, Wong, Carmen Chak Lui, Wong, Jack Chun Ming, Ng, Irene Oi Lin, Kai, Alan Ka Lun   +6 more
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Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]

, 2016
The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J., Gomez-Roman, Natividad, McGregor, Fiona, Plumb, Jane   +3 more
core   +1 more source