Results 21 to 30 of about 221,083 (372)
Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR- 18a-5p-HIF-1α Axis [PDF]
Frontiers in Physiology, 2021 Aims: Hypertension increases the risk of heart disease. Hallmark features of hypertensive heart disease is sympathoexcitation and cardiac mitochondrial abnormality. However, the molecular mechanisms for specifically neurally mediated mitochondrial abnormality and subsequent cardiac dysfunction are unclear.
Shyam Sundar Nandi +4 more
openaire +5 more sources
HIF-1α inhibits Wnt signaling pathway by activating Sost expression in osteoblasts. [PDF]
PLoS ONE, 2013 The nature of the cellular and molecular mechanisms for the transition of avascular cartilage replacement with bone during endochondral ossification remains poorly understood. One of the driving forces is hypoxia.
Dafu Chen +7 more
doaj +1 more source
Nature Communications, 2021 Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing HIF-1α-mediated transactivation and glycolysis ...
Fang Zheng +13 more
semanticscholar +1 more source
HIF-transcribed p53 chaperones HIF-1α [PDF]
Nucleic Acids Research, 2019 AbstractChronic hypoxia is associated with a variety of physiological conditions such as rheumatoid arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer. At the molecular level, hypoxia manifests its effects via activation of HIF-dependent transcription.
Esha Madan +18 more
openaire +3 more sources
Bioflavonoid luteolin prevents
The FASEB Journal, 2023 AbstractPreeclampsia (PE) is a serious hypertensive complication of pregnancy and is a leading cause of maternal death and major contributor to maternal and perinatal morbidity, including establishment of long‐term complications. The continued prevalence of PE stresses the need for identification of novel treatments which can target prohypertensive ...
Adrian C. Eddy +6 more
openaire +3 more sources
Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma. [PDF]
PLoS Pathogens, 2017 Primary effusion lymphoma (PEL) is an aggressive B-cell lymphoma with poor prognosis caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Previous studies have revealed that HIF-1α, which mediates much of the cellular response to hypoxia, plays an ...
Prabha Shrestha +5 more
doaj +1 more source
Cellular & Molecular Biology Letters, 2021 Background Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia regulatory protein.
Min Zhao +9 more
semanticscholar +1 more source
Blood, 2021 Key Points Neutrophils stabilize HIF-1α through the release of mitochondrial ROS. The glycerol 3-phosphate shuttle links glycolysis to HIF-1 stabilization, maintaining mitochondrial membrane potential and cell survival.
J. Willson +9 more
semanticscholar +1 more source
Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice [PDF]
Frontiers in Aging Neuroscience, 2015 The widely recognized neuroprotective effect of iron chelators is contributed by their ability to prevent reactive oxygen species (ROS) generation via the Fenton reaction, which sequesters redox-active Fe. An additional neuroprotective mechanism of iron-chelating compounds is to regulate the transcriptional activator hypoxia-inducible factor 1α (HIF-1α)
Rui Chai +7 more
openaire +3 more sources
HIF-1α in myocardial ischemia-reperfusion injury
Molecular Medicine Reports, 2021 Myocardial ischemia-reperfusion injury (MIRI) is a severe injury to the ischemic myocardium following the recovery of blood flow. Currently, there is no effective treatment for MIRI in clinical practice.
Jie Zheng +6 more
semanticscholar +1 more source