Results 31 to 40 of about 221,083 (372)
Journal of Orthopaedic Surgery and Research, 2023 Objective Hypoxia can promote stem cell proliferation and migration through HIF-1α. Hypoxia can regulate cellular endoplasmic reticulum (ER) stress. Some studies have reported the relationship among hypoxia, HIF-α, and ER stress, however, while little is
Jianxin Wu +8 more
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HIF-1α Contributes to Hypoxia-induced Invasion and Metastasis of Esophageal Carcinoma via Inhibiting E-cadherin and Promoting MMP-2 Expression [PDF]
, 2012 Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion and metastasis, but no study has reported its action in esophageal carcinoma.
Cheng, Yun-Jie +7 more
core +1 more source
Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts [PDF]
Scientific Reports, 2020 AbstractRecent evidence has emerged that cancer cells can use various metabolites as fuel sources. Restricting cultured cancer cells to sole metabolite fuel sources can promote metabolic changes leading to enhanced glycolysis or mitochondrial OXPHOS. However, the effect of metabolite-restriction on non-transformed cells remains largely unexplored. Here
Kozlov, Alexandra M. +3 more
openaire +5 more sources
HIF-1α Induces Multidrug Resistance in Gastric Cancer Cells by Inducing MiR-27a. [PDF]
PLoS ONE, 2015 This study aimed to determine the correlation between HIF-1α and miR-27a expression and to evaluate the effect of inhibition of HIF-1α expression on miR-27a expression and drug resistance in gastric cancer (GC).
Qun Zhao +5 more
doaj +1 more source
Cells, 2023 Hypoxia-inducible factor (HIF)-1α represents an oxygen-sensitive subunit of HIF transcriptional factor, which is usually degraded in normoxia and stabilized in hypoxia to regulate several target gene expressions.
Flaminia Chellini +7 more
doaj +1 more source
Early redox activities modulate Xenopus tail regeneration. [PDF]
, 2018 Redox state sustained by reactive oxygen species (ROS) is crucial for regeneration; however, the interplay between oxygen (O2), ROS and hypoxia-inducible factors (HIF) remains elusive.
Ferreira, Fernando +4 more
core +2 more sources
Journal of Experimental Medicine, 2014 Hypoxia selectively up-regulates PD-L1 on myeloid-derived suppressor cells via HIF-1a, thus affecting T cell activation.
M. Noman +7 more
semanticscholar +1 more source
Positive correlation between the expression of hEag1 and HIF-1α in breast cancers: an observational study [PDF]
BMJ Open, 2014 ObjectivesTo explore the expression patterns of Eag1 (ether á go-go 1) and HIF-1α (hypoxia-inducible factor 1α) in a cohort of patients with breast cancer.SettingDepartment of general surgery in an upper first-class hospital in Xi'an, China.ParticipantsA total of 112 female Han Chinese patients with a diagnosis of invasive ductal carcinoma were ...
Ting Wang +9 more
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HIF-1α, a novel piece in the NF-κB puzzle [PDF]
, 2015 Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
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HIF-1α in heart: Protective mechanisms
American Journal of Physiology-Heart and Circulatory Physiology, 2013 Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that directs many of the cellular responses to hypoxia. In these studies, we have used a mouse model containing a cardiac-specific, oxygen-stabilized, doxycycline (Dox)-off regulated HIF-1α transgene to probe the role of HIF-1α in cardioprotection. Hearts used in these studies were derived
Wu, Joe +7 more
openaire +5 more sources