Results 51 to 60 of about 135,194 (207)

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

Genes and Diseases
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to ...
Yu Wei, Dian Zhang, He Shi, Husun Qian, Hongling Chen, Qian Zeng, Fangfang Jin, Yan Ye, Zuli Ou, Minkang Guo, Bianqin Guo, Tingmei Chen   +11 more
doaj   +1 more source

HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis

World Journal of Surgical Oncology, 2020
Background The role of hypoxia-inducible factor-1α (HIF-1α) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear.
Yuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saito, Chie Takasu, Shinichiro Yamada, Mitsuo Shimada   +7 more
doaj   +1 more source

Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium [PDF]

, 2016
Airway epithelial CD55 down-regulation occurs in several hypoxia-associated pulmonary diseases, but the mechanism is unknown. Using in vivo and in vitro assays of pharmacologic inhibition and gene silencing, the current study investigated the role of ...
Blum, Janice S., Fisher, Amanda J., Gracon, Adam, Lahm, Tim, Lipking, Kelsey P., Mickler, Elizabeth A., Murray, Mary, Pandya, Pankita H., Pollok, Karen, Renbarger, Jamie, Rothhaar, Katia, Sandusky, George E., Temm, Constance J., Wilkes, David S.   +13 more
core   +2 more sources

No Amplifications of Hypoxia-Inducible Factor-1α Gene in Invasive Breast Cancer: A Tissue Microarray Study

Cellular Oncology, 2004
Objective: Hypoxia Inducible Factor‐1 (HIF‐1) is an important transcription factor that stimulates tumour growth and metastases via several pathways, including angiogenesis and altered metabolism.
Marije M. Vleugel, Reinhard Bos, Horst Buerger, Petra van der Groep, Outi R. Saramäki, Tapio Visakorpi, Elsken van der Wall, Paul J. van Diest   +7 more
doaj   +1 more source

Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes

Journal of Neuroinflammation, 2007
Background Neuroinflammation has been implicated in various brain pathologies characterized by hypoxia and ischemia. Astroglia play an important role in the initiation and propagation of hypoxia/ischemia-induced inflammation by secreting inflammatory ...
Mojsilovic-Petrovic Jelena, Callaghan Debbie, Cui Hong, Dean Clare, Stanimirovic Danica B, Zhang Wandong   +5 more
doaj   +1 more source

Long Non-Coding RNA CASC9 And HIF-1α Form A Positive Feedback Loop To Facilitate Cell Proliferation And Metastasis In Lung Cancer.

OncoTargets and therapy, 2019
The long noncoding RNA cancer susceptibility 9 (CASC9) has been recognized as an important modulator of cell growth and metastasis in many cancers. However, its detailed roles in lung cancer remain unclear. In this study, we aimed to investigate its functions and molecular mechanism in lung cancer progression.Expression of CASC9 was determined in lung ...
Jin,Yuxing, Xie,Huikang, Duan,Liang, Zhao,Deping, Ding,Jiaan, Jiang,Gening   +5 more
openaire   +3 more sources

The Effect of Neoadjuvant Chemotherapy on HIF-1α Expression in Cervical Uterine Cancer [PDF]

, 2018
Background: Uterine cervical cancer is one of the main causes of female death related to cancer. Neoadjuvant chemotherapy aims to reduce tumor mass to allow radical surgery.
Priyanto, H. (Heru), Respati, S. H. (Supriyadi), Sulistyowati, S. (Sri), Wiraswesty, I. (Ika)   +3 more
core   +2 more sources

Role of hypoxia inducible factor-1α in remote limb ischemic preconditioning. [PDF]

, 2013
Remote ischemic preconditioning (RIPC) has emerged as a feasible and attractive therapeutic procedure for heart protection against ischemia/reperfusion (I/R) injury. However, its molecular mechanisms remain poorly understood. Hypoxia inducible factor-1α (
A. Berdeaux, A. Furber, B. Ghaleh, D. Godin-Ribuot, F. Prunier, H. Kalakech, P. Carmeliet, S. Pons, S. Tamareille, V. Martin   +9 more
core   +3 more sources

Increased HIF-1α expression in T cells and associated with enhanced Th17 pathway in systemic lupus erythematosus

Journal of the Formosan Medical Association, 2022
Background/Purpose: Recent emerging evidence indicates that dysfunction of metabolic remodeling underlies aberrant T cell immune responses in systemic lupus erythematosus (SLE).
Hsiu-Jung Liao, Ching-Liang Chu, Szu-Chieh Wang, Hua-Yi Lee, Chien-Sheng Wu   +4 more
doaj   +1 more source

microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma. [PDF]

, 2017
Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote ...
Cao, Ke, Chen, Jia, Chen, Xiang, Chen, Yao, Chen, Yong, Cheng, Yan, Li, Jingjing, Qian, Li, Tang, Jintian, Tang, Shijie, Wang, Aijun, Xiong, Wei, Zhou, Jianda   +12 more
core   +1 more source