Results 61 to 70 of about 135,194 (207)

Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription

Redox Biology, 2017
Mitochondria are the main consumers of molecular O2 in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF-α).
Antonina N. Shvetsova, Daniela Mennerich, Juha M. Kerätär, J. Kalervo Hiltunen, Thomas Kietzmann   +4 more
doaj   +1 more source

A regulatory feedback loop between HIF-1α and PIM2 in HepG2 cells. [PDF]

PLoS ONE, 2014
To survive under hypoxic conditions, cancer cells remodel glucose metabolism to support tumor progression. HIF transcription factor is essential for cellular response to hypoxia.
Zhenhai Yu, Xiaoping Zhao, Yingying Ge, Teng Zhang, Liangqian Huang, Xiang Zhou, Lei Xie, Jianjun Liu, Gang Huang   +8 more
doaj   +1 more source

Inhibition of HIF-1 alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma [PDF]

, 2015
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Acland, Assenat, Bazhin, Carbone, Chaput, Chen, Chouaib, Danenberg, David, Dyson, El-Deiry, Gallick, Gelovani, Ghansah, Giese, Gil, Gress, Gribben, Hao, Hao, Hao, Henson, Jemal, Kiessling, Kroemer, Kroemer, Kroemer, Levi, Luo, Mi, Moses, Plate, Powis, Powis, Powis, Ravichandran, Ricci, Rodeck, Sarker, Schuler, Semenza, Singh, Spisek, Tani, Vandenabeele, Wang, Wang, Zitvogel, Zitvogel, Zitvogel   +49 more
core   +1 more source

ILKAP Binding to and Dephosphorylating HIF-1α is Essential for Apoptosis Induced by Severe Hypoxia

Cellular Physiology and Biochemistry, 2018
Background/Aims: Integrin-linked kinase-associated phosphatase (ILKAP), a serine/threonine phosphatase that belongs to the protein phosphatase 2C family, has a role in cell survival and apoptosis.
Tielong Liu, Yonggang Liu, Jiashi Cao, Xin Gao, Jing Wang, Guanghui Chen, Yang Wang, Ge Liu, Guangjian Bai, Yiwei Hu, Jiaxiang Yang, Lianfeng Dong, Xinbao Quan, Weiwei Zou   +13 more
doaj   +1 more source

Hepatic Hypoxia-Inducible Factor 1α Mediates Ferroptosis via Transferrin Receptor 1 in Acute Liver Injury

Antioxidants
Acute liver injury (ALI) is a potentially life-threatening condition lacking effective clinical drugs. Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of both inflammation and metabolism.
Jiayu Yang, Meicheng Wang, Shichao Cui, Yulan Xia, Yinfang Xie, Zhu Hu, Ni Li, Xinwen Zhang, Pengfei Zhu, Xu Yu, Linshi Wu, Jingya Li   +11 more
doaj   +1 more source

Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems [PDF]

, 2014
HIF (hypoxia inducible factor) is an oxygen-regulated transcription factor that mediates the intracellular response to hypoxia in human cells. There is increasing evidence that cell signaling pathways encode temporal information, and thus cell fate may ...
Bagnall, James, Bearon, Rachel, Fercher, Andreas, Herrmann, Anne, Leedale, Joe, Papkovsky, Dmitri, See, Violaine   +6 more
core   +1 more source

HIF-1α contributes to Ang II-induced inflammatory cytokine production in podocytes

BMC Pharmacology and Toxicology, 2019
Background Studies have indicated that changed expression of hypoxia-inducible factor-1α (HIF-1α) in epithelial cells from the kidney could affect the renal function in chronic kidney disease (CKD).
Hao Huang, Yanqin Fan, Zhao Gao, Wei Wang, Ning Shao, Lu Zhang, Yingjie Yang, Weifang Zhu, Zhaowei Chen, Jijia Hu, Guohua Ding   +10 more
doaj   +1 more source

Hypoxia and tissue destruction in pulmonary TB. [PDF]

, 2016
BACKGROUND: It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix metalloproteinases (MMPs), particularly collagenases such as ...
Aigbirhio, Franklin, Al-Nahhas, Adil, Belton, Moerida, Brilha, Sara, Dembek, Marcin, Elkington, Paul T, Friedland, Jon S, Fryer, Tim D, Green, Justin, Hong, Young T, Manavaki, Roido, Mauri, Francesco, Moores, Rachel, Nijran, Kuldip, Patel, Neva H, Tezera, Liku   +15 more
core   +6 more sources

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A [PDF]

, 2015
Despite the approval of numerous molecular targeted drugs, long-term antiproliferative efficacy is rarely achieved and therapy resistance remains a central obstacle of cancer care.
Adjaye, Blüthgen, Brune, Chen, Chiaradonna, Coe, Colgan, Cramer, Cramer, Cramer, Cramer, Cramer, Cramer, Cramer, D'Acquisto, Dang, Dang, Dang, DeBerardinis, Denko, Eilers, Gatenby, Goldberg, Hickey, Hocker, Hocker, Hwang, Iliopoulos, Iliopoulos, Jeoung, Kempa, Kinzler, Lengauer, Maehara, Maehara, McCormick, Monden, Moss, Nakamura, Parkinson, Rha, Rigas, Rock, Rosewicz, Schultz, Semenza, Semenza, Semenza, Simon, Smith, Stratford, Tavar, Thompson, Thompson, Thompson, Wang, Weckwerth, West, Xie, Yaffe, Zhang   +60 more
core   +3 more sources

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer. [PDF]

PLoS ONE, 2015
It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1α) is involved in cancer metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a hypoxia-mimetic agent, induces epithelial-mesenchymal transition (EMT) in ...
Wenjing Zhang, Xinpeng Shi, Ying Peng, Meiyan Wu, Pei Zhang, Ruyi Xie, Yao Wu, Qingqing Yan, Side Liu, Jide Wang   +9 more
doaj   +1 more source