Results 111 to 120 of about 57,100 (255)
VHL knockout in mice releases tubular HIF-2α expression.
, 2012 HIF-1α and HIF-2α expression was analyzed by immunohistochemistry in the kidney cortex (upper panels) and medulla (lower panels) of inducible triple transgenic Pax8-VHL−/− mice after 3 days of doxycyclin treatment (0.2 mg/ml in drinking water). HIF-1α as
Ruth E. Schietke (186088) +19 more
core +1 more source
Advanced Science, EarlyView.A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun +9 more
wiley +1 more source
Communications BiologyHypoxia tolerance is mainly controlled by the hypoxia signaling pathway and HIF-1α/2α serve as master regulators in this pathway. Here we identify MYLIP, an E3 ubiquitin ligase thought to specifically target lipoprotein receptors, as a downstream target ...
Jun Li +10 more
doaj +1 more source
Advanced Science, EarlyView.PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan +18 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang +14 more
wiley +1 more source
HIF-2α levels in HIF-2α−/− and WT mouse kidneys.
, 2013 A, HIF-2α−/− mice or their wild-type littermates were exposed to left UO, which continued for 24 hours, and then was released. 2 days after release of UO or at the corresponding time point in the non-UO sham-operated mice, the left kidneys were harvested
Jian-Jun Zhang (334146) +6 more
core +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
HIF-1α and HIF-2α IHC signals in hypoxic areas of transgenic mouse mammary tumours.
, 2016 A, C Hypoxyprobe (Hyp.pr.) allows visualisation of hypoxic tumour areas. B. Hypoxic peri-necrotic HIF-1α-positive cells display nuclear staining. D. HIF-2α-positive cells show cytoplasmic staining with or without appreciable nuclear staining. * necrosis.
Sven Påhlman (23247) +2 more
core +1 more source
Advanced Science, EarlyView.Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu +5 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyHypoxia-inducible factors (HIFs) are essential to the homeostasis of hypoxic tissues. Although HIF-2α, is expressed in nucleus pulposus (NP) cells, consequences of elevated HIF-2 activity on disc health remains unknown.
Shira N. Johnston +8 more
doaj +1 more source