Results 121 to 130 of about 57,100 (255)

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells

, 2014
International audienceGlioblastoma multiforme (GBM) is the deadliest form of primary brain cancer. Several reports have indicated aberrant levels of βIII-tubulin (βIII-t) in human GBM.
Bernaudin, Myriam, Grandval, Alexandra, Alexandra Grandval, Leilane Cuhna-Alves, Cuhna-Alves, Leilane, Emmanuèle Lechapt-Zalcman, Bordji, Karim, Lechapt-Zalcman, Emmanuèle, Myriam Bernaudin, Karim Bordji   +9 more
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Gene silencing of HIF-2α disrupts glioblastoma stem cell phenotype

, 2020
Aim: Improved treatment strategies are desperately needed for eradicating cancer stem cells (CSCs), which drive malignancy and recurrence in glioblastoma multiforme.
Roth, Charles M., Tanna, Shaili, Nusblat, Leora M.   +2 more
core  

Quantitative assessment of dimer formation by hypoxia inducible transcription factor subunits HIF-1α and HIF-2α [PDF]

, 2014
Oxygen homeostasis in cells and tissues is tightly controlled by the transcription factors Hypoxia Inducible Factors (HIFs) which regulate the expression of genes that facilitate O2 delivery and metabolic adaptation to O2 deprivation in all mammalian ...
Hu, Jun
core  

Transient ureteral obstruction prevents against kidney ischemia/reperfusion injury via hypoxia-inducible factor (HIF)-2α activation.

, 2012
Although the protective effect of transient ureteral obstruction (UO) prior to ischemia on subsequent renal ischemia/reperfusion (I/R) injury has been documented, the underlying molecular mechanism remains to be understood. We showed in the current study
Zhang Ming, Long-Mei Xu, Zhang Jian-Jun, Xiao-Song Chen, Chen Xiao-Song, Shun Zhang, Zhang Shun, Ming Zhang, Han Cong-Hui, Xia Qiang, Jian-Jun Zhang, Cong-Hui Han, Xu Long-Mei, Qiang Xia   +13 more
core   +1 more source

GSLR Drives Lung Adenocarcinoma as a Critical Regulator of Energy Homeostasis Through Creatine Kinase B Activation

Advanced Science, EarlyView.
This study identifies the glucose/glutamine sensitive lncRNA GSLR as a driver of lung adenocarcinoma progression. Nutrient restriction reduces chromatin accessibility at the GSLR locus and blocks CTCF‐mediated transcriptional regulation. GSLR directly interacts with DHX9 and recruits it to the CKB promoter, arresting R‐loop accumulation and promoting ...
Xinyi Qian, Juze Yang, Jiayi Ren, Xiaowei Mao, Jia Li, Tengfei Sun, Liangliang Dong, Enguo Chen, Yan Lu, Pengyuan Liu   +9 more
wiley   +1 more source

Hypoxia-inducible factor-2α promotes chemoresistance in glioblastoma cells via transforming growth factor-β2

陆军军医大学学报
Objective Hypoxia in the tumor microenvironment is a critical factor contributing to chemoresistance in glioblastoma. This study preliminarily investigates the role of hypoxia-inducible factor-2α (HIF-2α) and transforming growth factor-β2 (TGF-β2) in ...
ZHAO Lu, WANG Pan
doaj   +1 more source

CXCR4 is hypoxia inducible, but only the target gene of HIF-2α.

, 2013
(A) Western blots of whole cell lysates for HIF-1α, HIF-2α and CXCR4 expression under hypoxic condition, demonstrating hypoxia increases CXCR4 abundance. (B) Western blots of SW1116 cells expressing shHIF-1α and shHIF-2α. The cells were treated with 1 mM
Dirk M. Hermann (303570), Huifan Ji (303567), Eric Metzen (303571), Fengyan Jin (303565), Chunshu Jia (303568), Ulf Brockmeier (303569), Yingqiao Zhu (303572), Baorong Chi (303573)   +7 more
core   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source