Results 191 to 200 of about 57,100 (255)

Association of serums HIF-1α and HIF-2α with the levels and severity of renal fibrosis: a retrospective cohort study. [PDF]

BMC Nephrol
Zhang X, Zhang W, Waheed YA, Li S, Sun D.   +4 more
europepmc   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Clinically approved HIF-PHIs modulate redox metabolism, cell growth, and angiogenesis independent of HIF-1α/HIF-2α. [PDF]

Redox Biol
Mennerich D, Khoder-Agha F, Beter M, Dimova EY, Ylä-Herttuala S, Kietzmann T.   +5 more
europepmc   +1 more source

Effects of Obstructive Sleep Apnea on Personality and Temperament: A Cohort and Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Obstructive sleep apnea (OSA) is associated with neurocognitive impairment, but its causal relationship with personality traits remains poorly understood. This study investigates the association and causality between OSA and personality using both cohort and genetic data.
Jian‐Hong Liao, Yun‐Han Shi, Xin‐Peng Xu, Yan‐Ru Li, De‐Min Han   +4 more
wiley   +1 more source

A novel activating somatic mutation in EPAS1, coding for HIF-2α, in a patient with a paraganglioma and sickle cell disease. [PDF]

Arch Endocrinol Metab
Shekhda KM, Iyer R, Robledo M, Nara V, Luong TV, Caplin M, Grossman AB.   +6 more
europepmc   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

VHL-recruiting PROTAC attenuates AKI-CKD transition via simultaneous degradation of Smad3 and stabilization of HIF-2α. [PDF]

Cell Death Dis
Ruan Y, Wang D, Xu Y, Yang J, Chen Y, Fan J, Tang SCW, Chen W, Wang X.   +8 more
europepmc   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Gut Microbiome Functional Reprogramming Reflects Divergent Social Strategies in a Wild Primate

Integrative Zoology, EarlyView.
Wild golden snub‐nosed monkeys employ divergent social strategies, forming reproductive one‐male units and bachelor all‐male units. We reveal that these social structures, intertwined with seasonal diets, drive distinct functional reprogramming in their gut microbiomes. This adaptive microbial plasticity plays a crucial role in primate socio‐ecological
Guanwei Lan, Xianjun Li, Zhantao Lu, Yue Zhang, Feifei Feng, Juan Liu, Wei Wu, Jiabin Liu, Yanshan Zhou, Jiang Gu, Rui Ma, Dunwu Qi   +11 more
wiley   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source