Results 201 to 210 of about 57,100 (255)

Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation. [PDF]

Signal Transduct Target Ther
Zhang K, He L, Wang Y, Qin S, Yu C, Zheng E, Zhang Z, Xu Y, Chen X, Liu Y, Liu X, Guan S, Xia L, Suo F, Pei F, Du J, Su Y, Li Y, Wu Y, Zhou X, Zhou J, Cai L, Tang X, Zhang Z, Shang Y, Zhang Q, Gong K, Sun L.   +27 more
europepmc   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Development of a Novel HIF-2α PET Tracer for Noninvasive Tumor Hypoxia Imaging. [PDF]

ACS Omega
Wang Y, Wang Y, Bai P, Cui J, Zhou Y, Li H, Wu L, Wang H, Bai S, Ya R, Bai X, Liu Z, Liu T.   +12 more
europepmc   +1 more source

Genome‐wide association and interaction analysis for proliferative retinopathy in adults with type 2 diabetes born during famine: The DOLCE study in Ukraine

Acta Ophthalmologica, EarlyView.
Abstract Purpose Proliferative diabetic retinopathy (PDR) is one of the leading causes of blindness in working‐age adults. We have previously shown that the risk of PDR is significantly elevated in individuals with intrauterine exposure to famine. However, the genetic mechanisms mediating this association remain unknown.
Olena Fedotkina, Most Champa Begum, Xuan Tung Trinh, Turkuler Özgumus, Mikael Åkerlund, Peter Nilsson, Leticia Maria Spindola, Valeriya Lyssenko   +7 more
wiley   +1 more source

Phosphorylation at S345 Converts HIF-2α from a Transcription Factor to an RNA binding protein

Albanese A, Daly LA, Prost-Fingerle K, Elliott LG, Oswald SO, Ecclestone GB, Bell G, Batie M, Rigden DJ, Eyers CE, Fandrey J, Kenneth NS, See V, Rocha S.   +13 more
europepmc   +1 more source

Mode-dependent effects of chemical, intermittent, and hypobaric hypoxia on HIF-1α, HIF-2α, HIF-3α, PACAP, and PAI mRNA expression in the single prolonged stress model of PTSD. [PDF]

Front Neurosci
Porkhalo D, Pashevin D, Naumenko Y, Koval R, Kozlovska M, Kamkina M, Tytarenko Y, Portnychenko A, Dosenko V.   +8 more
europepmc   +1 more source

CD47 promotes myeloma cell growth through JAK–STAT3/MYC signalling and is targetable by ruxolitinib

British Journal of Haematology, EarlyView.
Summary Cluster of differentiation 47 (CD47), a ‘don't eat me’ immune checkpoint receptor, is frequently overexpressed on multiple myeloma (MM) cells and contributes to immune evasion. While its immune regulatory function is well established, the intrinsic oncogenic role of CD47 remains poorly understood.
Omar Faruq, Deepak Iyer, Patrick Wang, Mariusz Shrestha, Cuihong Wei, Aaron D. Schimmer, Hong Chang   +6 more
wiley   +1 more source

Iron Deficiency Impairs Muscle Stem Cell Proliferation and Skeletal Muscle Regeneration via HIF-2α Stabilization. [PDF]

J Cachexia Sarcopenia Muscle
Fu W, Liu Y, Yin A, Xie L, Yin H.
europepmc   +1 more source

D‐amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose D‐amino acid oxidase (DAO) has been developed as a chemogenetic tool, to precisely manipulate redox levels in tissues and cells by generating H2O2 in the presence of D‐amino acids. The enzyme's significant oxygen consumption during H2O2 production may influence cellular oxygen levels.
Wiebke Maurer, Anke Zieseniss, Vamsi Priya Vikram, Yamin Chen, Laura Bauer, Annette Hillemann, Peter Rehling, Maithily S. Nanadikar, Diane de Zélicourt, Vartan Kurtcuoglu, Dörthe M. Katschinski   +10 more
wiley   +1 more source