Results 31 to 40 of about 124,612 (246)

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success [PDF]

Cancer Cell, 2012
The hypoxia inducible transcription factors (HIFs) control many mediators of vascular response, including both angiogenic factors and small molecules such as nitric oxide (NO). In studying how endothelial HIF response itself affects metastasis, we found that loss of HIF-1α in endothelial cells reduces NO synthesis, retards tumor cell migration through ...
Branco-Price, Cristina, Zhang, N. A., Schnelle, Moritz, Evans, Colin, Katschinski, Doerthe Magdalena, Liao, Debbie, Ellies, Lesley, Johnson, Randall S.   +7 more
openaire   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

HyperPointFormer: Multimodal Fusion in 3-D Space With Dual-Branch Cross-Attention Transformers

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Multimodal remote sensing data, including spectral and LiDAR or photogrammetry, is crucial for achieving satisfactory land-use/land-cover classification results in urban scenes. So far, most studies have been conducted in a 2-D context.
Aldino Rizaldy, Richard Gloaguen, Fabian Ewald Fassnacht, Pedram Ghamisi   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Hypoxia‐Inducible Factor‐2α Signaling in the Skeletal System

JBMR Plus, 2023
Hypoxia‐inducible factors (HIFs) are oxygen‐dependent heterodimeric transcription factors that mediate molecular responses to reductions in cellular oxygen (hypoxia).
Sarah V Mendoza, Damian C Genetos, Clare E Yellowley   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pyrometallurgical valorization of waelz, fayalite, and linz-donawitz slag mixtures

Scientific Reports
Waelz, Linz-Donawitz, and Fayalite slags are one of the largest industrial byproducts. They are presently under-utilized, and ending up in landfill. This work demonstrates that mixtures of these slags can be directly valorized, given that the combined ...
Junnile L. Romero, Volker Recksiek, Rafaela Debastiani, Md Naziat Hossain, Ludwig Blenau, Alexandros Charitos, Ari O. Vaisanen, Ajay B. Patil   +7 more
doaj   +1 more source

Hypoxia-induced cardioprotection: A review [PDF]

Arhiv za farmaciju
Hypoxia, a state of reduced oxygen availability, exerts complex and often paradoxical effects on the heart. While chronic hypoxia is detrimental and leads to adverse cardiac remodeling and dysfunction, short-term or intermittent hypoxia can contribute ...
Shameem Mohammed Abdul Khaja, Sen Alexa, Vikram Rajeev, Xia Chenchen, Alshehri Ahmad A.   +4 more
doaj   +1 more source