Results 81 to 90 of about 124,612 (246)

Peculiarities of expression of HIF-1Α and HIF-3Α in hypothalamus of Wistar rats under the influence of intermittent hypobaric hypoxia

Patologìâ, 2017
The purpose of this study was to establish the features of the expression of hif‑1α and hif-3α genes and the accumulation of HIF-1α and HIF-3α proteins in the paraventricular (PVH) and supraoptic (SO) nuclei of the hypothalamus under the conditions of ...
A. V. Abramov, V. A. Shamenko
doaj   +1 more source

PDZK1‐ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reveals that PDZK1 loss impairs ULK1‐mediated lipophagy, driving lipid droplet accumulation and sunitinib resistance in clear cell renal cell carcinoma. PDZK1 inhibits LEF1 nuclear translocation, enhancing ULK1 transcription. Pharmacological ULK1 activation resensitizes resistant tumors to sunitinib.
Xuan Qi, Yu Guo, Yumeng Yang, Haibo Wang, Xiaomei Yang, Ran Song, Qiong Qin, Yan Zhang, Meihan Hu, Haixing Zhou, Duiping Feng, Junqi He   +11 more
wiley   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

PLoS ONE, 2010
BackgroundHypoxia inducible factor-1α (HIF-1α) is responsible for the majority of HIF-1-induced gene expression changes under hypoxia and for the "angiogenic switch" during tumor progression.
Lavinia Nardinocchi, Valentina Pantisano, Rosa Puca, Manuela Porru, Aurora Aiello, Annalisa Grasselli, Carlo Leonetti, Michal Safran, Gideon Rechavi, David Givol, Antonella Farsetti, Gabriella D'Orazi   +11 more
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.

PLoS ONE, 2015
Hypoxia is a state of decreased oxygen reaching the tissues of the body. During prenatal development, the fetus experiences localized occurrences of hypoxia that are essential for proper organogenesis and survival.
Yogesh Saini, Steven P Proper, Peter Dornbos, Krista K Greenwood, Anna K Kopec, Scott G Lynn, Elizabeth Grier, Lyle D Burgoon, Timothy R Zacharewski, Russell S Thomas, Jack R Harkema, John J LaPres   +11 more
doaj   +1 more source

Oxygen sensing by HIF hydroxylases

Nature Reviews Molecular Cell Biology, 2004
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation.
Schofield, C, Ratcliffe, P
openaire   +2 more sources

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Evaluation of the Removal of PVDF Using ToF-SIMS: Comparing Dihydrolevoglucosenone and Pyrolysis as Pretreatments for Cathode Materials of Lithium-Ion Batteries

Recycling
Effective and environmentally benign removal of polyvinylidene fluoride (PVDF) binders from spent battery electrodes remains a critical hurdle in sustainable recycling, primarily due to issues related to the mitigation of fluorinated compound emissions ...
Marc Simon Henderson, Aliza Marie Salces, William D. A. Rickard, Denis Fougerouse, Álvaro José Rodríguez Medina, Elsayed A. Oraby, Chau Chun Beh, Martin Rudolph, Anna Vanderbruggen, Jacques Eksteen   +9 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source