High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal HIF2a/Iron-Metabolism Pathway [PDF]
Biomedicines, 2023 Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE.
Sisi Zhou, Jun Yan, Kang Song, Ri-Li Ge
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The gut–kidney axis in high-altitude hypoxia: pathophysiological mechanisms and the central role of hypoxia inducible factor [PDF]
Annals of MedicineBackground The high-altitude plateau environment, defined by hypobaric hypoxia, poses considerable health risks to human populations. Due to their substantial oxygen requirements, the kidneys are particularly susceptible, as are the intestines, with ...
Peiwen Wu +6 more
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High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation [PDF]
Discover OncologyThe unique hypoxic environment in high-altitude regions is increasingly drawing attention for its impact on the health of residents, particularly in patients post-chemotherapy.
Jing Shi +6 more
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High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis [PDF]
Cell Death DiscoveryTraumatic brain injury (TBI) is one of the leading causes of disability and mortality, which was classified as low-altitude TBI and high-altitude TBI. A large amount of literature shows that high-altitude TBI is associated with more severe neurological ...
Peng Zou +13 more
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Controlled Ascent Rate Enhances Autophagy and Mitigates Acute Lung Injury in Rats Exposed to High‐Altitude Hypoxia by Inhibiting Oxidative Stress and Inflammation [PDF]
Global ChallengesThe gradual ascent strategy, an effective measure to prevent acute mountain sickness by enabling the body to adapt to high–altitude hypoxia, has an unclear mechanism.
Kairui Huang +4 more
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Novel mechanisms of intestinal flora regulation in high-altitude hypoxia [PDF]
HeliyonBackground: This study investigates the molecular mechanisms behind firmicutes-mediated macrophage (Mψ) polarization and glycolytic metabolic reprogramming through HIF-1α in response to intrinsic mucosal barrier injury induced by high-altitude hypoxia ...
Fang Yan +4 more
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Research progress of orexin on the regulation of cardiovascular activities [PDF]
Jichu yixue yu linchuang, 2023 Orexin(OX) is a neuropeptide mainly released by the hypothalamus. In the central nervous system, orexin neurons form extensive connections with other neuronal nuclei and participate in energy metabolism, sleep cycle and cardiovascular activity regulation.
ZHU Minxia
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Efficacy and Safety of Intermittent Hypoxic Training in the Prevention of Acute Hypoxic Injury [PDF]
Zhongguo quanke yixue, 2023 Background Acute hypoxic injury caused by acute altitude exposure is manifested by different degrees of clinical symptoms, some of which may develop into acute mountain sickness (AMS). However, the current prevention and treatment methods are limited and
HUANG Dan, ZHANG Qihan, SONG Ge, WANG Qing, LI Yu, JI Xunming, WANG Yuan
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Frontiers in Psychiatry, 2021 Background: Sleep problems and eating disorders (EDs) are both serious public health concerns often seen in young adults. Yet, the underlying mechanisms for such associations are largely unknown.
Ruipeng Wu +16 more
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生物医学转化, 2021 High altitude pulmonary edema (HAPE) is a form of life-threatening high altitude idiopathy.This non-cardiogenic pulmonary edema is a serious illness with high risk of morbidity.
Gao Wenxiang +3 more
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