Results 21 to 30 of about 34,892 (283)

Pharmacokinetics of Acetaminophen and Metformin Hydrochloride in Rats After Exposure to Simulated High Altitude Hypoxia

open access: yesFrontiers in Pharmacology, 2021
The pharmacokinetic characteristics of drugs were altered under high altitude hypoxia, thereby affecting the absorption, distribution, metabolism, and excretion of drug. However, there are few literatures on the pharmacokinetic changes of antipyretic and
Jun-bo Zhu   +12 more
doaj   +1 more source

Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments. [PDF]

open access: yes, 2019
Impairments in cognitive function, mood, and sleep quality occur following ascent to high altitude. Low oxygen (hypoxia) and poor sleep quality are both linked to impaired cognitive performance, but their independent contributions at high altitude remain
Anza-Ramirez, Cecilia   +10 more
core   +2 more sources

Resveratrol Ameliorates High Altitude Hypoxia-Induced Osteoporosis by Suppressing the ROS/HIF Signaling Pathway

open access: yesMolecules, 2022
Hypoxia at high-altitude leads to osteoporosis. Resveratrol (RES), as an antioxidant, has been reported to promote osteoblastogenesis and suppress osteoclastogenesis.
Changqing Yan   +11 more
doaj   +1 more source

Identification of key pathways, genes and immune cell infiltration in hypoxia of high-altitude acclimatization via meta-analysis and integrated bioinformatics analysis

open access: yesFrontiers in Genetics, 2023
Background: For individuals acutely exposed to high-altitude regions, environmental hypobaric hypoxia induces several physiological or pathological responses, especially immune dysfunction.
Qiong Li   +11 more
doaj   +1 more source

Altitude and COVID‐19: Friend or foe? A narrative review

open access: yesPhysiological Reports, 2021
Recent reports suggest that high‐altitude residence may be beneficial in the novel coronavirus disease (COVID‐19) implicating that traveling to high places or using hypoxic conditioning thus could be favorable as well.
Grégoire P. Millet   +4 more
doaj   +1 more source

Ethiopian Native Highlander's Adaptation to Chronic High-Altitude Hypoxia. [PDF]

open access: yesBiomed Res Int, 2022
People living in a high‐altitude environment have distinct lifelong challenges. Adaptive mechanisms have allowed high‐altitude residents to survive in a low‐oxygen environment for thousands of years. The purpose of this review was to provide a brief review of the Ethiopian native highlanders’ adaptive mechanisms to chronic hypoxia problems at high ...
Getu A.
europepmc   +3 more sources

Hypoxic regulation of ion channel function and expression [PDF]

open access: yes, 2002
Acute hypoxia regulates the activity of specific ion channels in a rapid and reversible manner. Such effects underlie appropriate cellular responses to hypoxia which are designed to initiate cardiorespiratory reflexes and contribute importantly to other ...
Peers, C.
core   +1 more source

High-altitude hypoxia and preeclampsia [PDF]

open access: yesFrontiers in Bioscience, 2007
The influence of hypoxia (lowered arterial blood and/or tissue PO2) on fetoplacental development and the role of hypoxia in preeclampsia are major research foci in perinatal biology. While animal and cell models are of utility, we do not know whether artificial hypoxic stimuli mimic the pathological conditions attributed to hypoxic stress in vivo; we ...
openaire   +2 more sources

The physiological effects of hypobaric hypoxia versus normobaric hypoxia: a systematic review of crossover trials [PDF]

open access: yes, 2015
Much hypoxia research has been carried out at high altitude in a hypobaric hypoxia (HH) environment. Many research teams seek to replicate high-altitude conditions at lower altitudes in either hypobaric hypoxic conditions or normobaric hypoxic (NH ...
A Tucker   +25 more
core   +1 more source

Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness. [PDF]

open access: yes, 2013
Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility.
Begley, J   +11 more
core   +2 more sources

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