Results 31 to 40 of about 1,528,443 (167)

Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations

Clinical and Translational Radiation Oncology
The tissue sparing of ultra-high dose rate irradiation has been partially observed in vitro while controlling oxygen levels. Here, we developed a hypoxia system for high-throughput irradiations that accommodates embedded 3D cultures, such as organoids ...
Rutger Jan Cornelis de Koster, Jeremy Putra Gunawan, Hans Peters, Johan Bussink, Lara Barazzuol, Marc-Jan van Goethem, Alexander Gerbershagen, Robert Paul Coppes, Stefan Both   +8 more
doaj   +1 more source

Unexpected lower biochemical control of high-dose-rate brachytherapy boost than low-dose-rate brachytherapy boost for clinically localized prostate cancer

Clinical and Translational Radiation Oncology, 2020
Hideya Yamazaki, Koji Masui, Gen Suzuki, Ken Yoshida   +3 more
doaj   +1 more source

Monte Carlo modeling of ⁶⁰ Co HDR brachytherapy source in water and in different solid water phantom materials

Journal of Medical Physics, 2010
The reference medium for brachytherapy dose measurements is water. Accuracy of dose measurements of brachytherapy sources is critically dependent on precise measurement of the source-detector distance.
Sahoo S, Selvam T, Vishwakarma R, Chourasiya G   +3 more
doaj  

Low-dose-rate induces more severe cognitive impairment than high-dose-rate in rats exposed to chronic low-dose γ-radiation

Frontiers in Public Health
BackgroundOwing to the long penetration depth of gamma (γ)-rays, individuals working in ionizing radiation environments are chronically exposed to low-dose γ-radiation, resulting in cognitive changes.
Tianbao Ma, Tianbao Ma, Kexian Li, Wenjuan Sang, Xingyu Liu, Qun Luo, Ye Peng, Mingxing Wang, Xiu Luo, Jingjing Fang, Haijun Wang, Tao Wang, Changjing Zuo, Changjing Zuo   +13 more
doaj   +1 more source

Effects of ultra-high dose rate radiotherapy with different fractions and dose rate on acute and chronic lung injury in mice

Heliyon
Ultra-high dose rate radiotherapy (FLASH radiation) can naturally render normal tissues around the tumor tissue resistant to radiotherapy. In contrast, the tumor tissue remains sensitive to radiation under the same conditions.
Feng Gao, Binwei Lin, Yiwei Yang, Dexin Xiao, Zheng Zhou, Yu Zhang, Gang Feng, Jie Li, Dai Wu, Xiaobo Du, Qiuling Shi   +10 more
doaj   +1 more source

Adjuvant high dose rate brachytherapy for soft tissue sarcomas: initial experience report

Journal of Contemporary Brachytherapy, 2011
Purpose: Adjuvant high-dose-rate brachytherapy (HDRBT) offers advantages over low dose rate brachytherapy (LDRBT), although there are little data on local tumor control and treatment related toxicity. We report outcome in patients with primary, recurrent,
Robert Whitfield, Dian Wang, Donald Hackbarth, David King, Sara H. Kleinman, Jason Rownd, Julie A. Bradley   +6 more
doaj  

Treatment patterns of high-dose-rate and low-dose-rate brachytherapy as monotherapy for prostate cancer

Journal of Contemporary Brachytherapy, 2019
Justin Barnes, William Kennedy, Benjamin Fischer-Valuck, Brian Baumann, Jeff Michalski, Hiram Gay   +5 more
doaj   +1 more source

The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy

Frontiers in Oncology
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise ...
Josie May McGarrigle, Kenneth Richard Long, Kenneth Richard Long, Yolanda Prezado, Yolanda Prezado   +4 more
doaj   +1 more source

The Dose Rate of Corpuscular Ionizing Radiation Strongly Influences the Severity of DNA Damage, Cell Cycle Progression and Cellular Senescence in Human Epidermoid Carcinoma Cells

Current Issues in Molecular Biology
Modern radiotherapy utilizes a broad range of sources of ionizing radiation, both low-dose-rate (LDR) and high-dose-rate (HDR). However, the mechanisms underlying specific dose-rate effects remain unclear, especially for corpuscular radiation. To address
Sergey S. Soroko, Dmitry V. Skamnitskiy, Ekaterina N. Gorshkova, Olga M. Kutova, Ismail R. Seriev, Anna V. Maslennikova, Evgeniy L. Guryev, Sergey V. Gudkov, Vladimir A. Vodeneev, Irina V. Balalaeva, Natalia Yu Shilyagina   +10 more
doaj   +1 more source

High-dose-rate brachytherapy for high-grade vaginal intraepithelial neoplasia: a dosimetric analysis

Journal of Contemporary Brachytherapy, 2019
Amelia Barcellini, Mara Lecchi, Chiara Tenconi, Alessandra Macciotta, Emanuele Pignoli, Brigida Pappalardi, Ester Mazzarella, Mauro Carrara, Tommaso Giandini, Carlo Fallai, Paolo Verderio, Annamaria Cerrotta   +11 more
doaj   +1 more source