Results 141 to 150 of about 620,339 (314)

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Metabolic adaptations to high-fat diet [PDF]

Nature Reviews Endocrinology, 2018
openaire   +2 more sources

Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice

, 2011
Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in ...
HT Nicholls (15871418), GI Lancaster (11990369), S Risis (13534441), NK Watson (15871421), MA Febbraio (9644273), Greg Kowalski (13079640), Clinton Bruce (13064589), Alex Bobik (335995), Peter Kanellakis (335991)   +8 more
core  

Responses to oleic, linoleic and alpha linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

, 2013
We investigated the changes in adiposity, cardiovascular and liver structure and function, and tissue fatty acid compositions in response to oleic acid-rich macadamia oil, linoleic acid-rich safflower oil and α-linolenic acid-rich flaxseed oil (C18 ...
Ward, Leigh C., Kumar, Senthil A., Iyer, Aarjit, Poudyal, Hemant, Brown, Lindsay, Waanders, Jennifer   +5 more
core   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Evaluation of Effects of High Fat Diets on Cardiovascular Disease Risk Factors in Albino Rats

Sokoto Journal of Medical Laboratory Science, 2017
The consumption of high fat diet (HFD) is considered a risk factor for development of coronary heart disease (CHD). In our study, 28 albino rats (99-113g and aged 10-12 weeks) were divided into four groups of seven (7) rats each.
Bunza, F. U. * and Wasagu, I. Z.
doaj  

Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats

, 2011
Metabolic syndrome (obesity, diabetes, and hypertension) increases hepatic and cardiovascular damage. This study investigated preventive or reversal responses to rutin in high-carbohydrate, high-fat diet-fed rats as a model of metabolic syndrome.
Arumugam, Thiruma V., Lindsay Brown, Panchal, Sunil K., Poudyal, Hemant, Brown, Lindsay, Thiruma V. Arumugam, Panchal, Sunil K. (R20071), Hemant Poudyal, Sunil K. Panchal   +8 more
core   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Alterations to the microbiota-colon-brain axis in high-fat-diet-induced obese mice compared to diet-resistant mice

, 2019
Obesity is underpinned by both genetic and environmental factors, including a high-saturated-fat diet. Some mice develop diet-induced obesity (DIO), but others remain diet resistant (DR) despite intake of the same high-saturated-fat diet, a phenomenon ...
Yanfang Qin (5308361), Qingling Wang (485692), Renxian Tang (5183018), Peng Zhang (20117664), Kuiyang Zheng (5183021), Xu-Feng Huang (19584460), Yinghua Yu (19588399), Katrina Green (19586707), Yuan Zhou (179597), Xiangyang Li (162313), Hongqin Wang (20121813)   +10 more
core  

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source