Results 41 to 50 of about 10,771 (216)

Outcomes of prostate atypical small acinar proliferation and high-grade prostate intraepithelial neoplasm patients

open access: yesUrological Science, 2018
Objective: Atypical small acinar proliferation (ASAP) and high-grade prostatic intraepithelial neoplasia (HGPIN) are two pathological findings occasionally noted in prostate biopsies.
Sheng-Yung Tung   +7 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

High-Grade Prostatic Intraepithelial Neoplasia

open access: yesArchives of Pathology & Laboratory Medicine, 2001
I has been more than a decade since specific criteria for the recognition and grading of prostatic intraepithelial neoplasia (PIN) were first published.1,2 Prostatic intraepithelial neoplasia is now divided into 2 grades: low grade (PIN 1) and high grade (PIN 2 and 3).
openaire   +1 more source

Building a Robust Investigator‐Initiated Platform: The I‐CARE Experience

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Investigator‐initiated studies that include information collected by patients are rising, but limited data is available on patient and investigator experience in this setting. The I‐CARE cohort included patients with inflammatory bowel disease (IBD) monthly collecting clinical information in 15 countries for up to 6 years.
Julien Kirchgesner   +906 more
wiley   +1 more source

Translationally controlled tumor protein in prostatic adenocarcinoma: correlation with tumor grading and treatment-related changes [PDF]

open access: yes, 2015
12Prostate cancer is the second leading cause of cancer-related death. The androgen deprivation therapy is the standard treatment for advanced stages. Unfortunately, virtually all tumors become resistant to androgen withdrawal.
Alessandro Ginori   +11 more
core   +7 more sources

Dynamics of the association between circulating levels of miRNA and pancreatic cancer risk through the years prior to pancreatic cancer diagnosis

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Early diagnosis is critical for improving pancreatic ductal adenocarcinoma prognosis, but few biomarkers currently exist. In a case–control study of 1,307 pancreatic cancer cases and matched pairs nested in prospective cohort studies, 13 miRNA–cancer associations were found to change during the blood‐draw‐to‐diagnosis time window.
Hui Cai   +10 more
wiley   +1 more source

The Role of Chronic Inflammation in Prostate Carcinogenesis: A Follow-Up Study

open access: yesAnnals of Urologic Oncology, 2019
Purpose To investigate the role of chronic inflammation in prostatic carcinogenesis with an emphasis on cancers of grade group 2 or above. Methods The presence/absence and extent of chronic inflammation and other relevant pathological findings were ...
Wei Chen   +3 more
doaj   +1 more source

The value of immunohistochemical research on PCNA, p53 and heat shock proteins in prostate cancer management: a review. [PDF]

open access: yes, 2006
This review addresses the significance of the expression of proliferating cell nuclear antigen (PCNA), p53 and some heat shock proteins (Hsps) in prostate carcinoma (PC).
ANZALONE, Rita   +7 more
core  

Autocrine regulation of human prostate carcinoma cell proliferation by somatostatin through the modulation of the SH2 domain containing protein tyrosine phosphatase (SHP)-1 [PDF]

open access: yes, 2002
The present study was intended to gain additional information on the growth regulation of prostate by somatostatin\ud (SRIF) and the intracellular events involved.
Angulo, Javier   +10 more
core   +3 more sources

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

open access: yesMed Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang   +12 more
wiley   +1 more source

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