Results 261 to 270 of about 559,451 (298)

High‐mobility group box‐1 in sterile inflammation

Journal of Internal Medicine, 2014
AbstractHigh‐mobility group box 1 (HMGB1) was originally defined as a ubiquitous nuclear protein, but it was later determined that the protein has different roles both inside and outside of cells. Nuclear HMGB1 regulates chromatin structure and gene transcription, whereas cytosolic HMGB1 is involved in inflammasome activation and autophagy ...
A, Tsung, S, Tohme, T R, Billiar
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High-mobility group box 1 in multiple sclerosis

Immunologic Research, 2015
This study is one in series determining the potential of RAGE axis (receptor for advanced glycation end products, isoforms, ligands) as a biomarker in multiple sclerosis (MS). We evaluated serum levels of RAGE ligand, the high-mobility group box (HMGB)1 in MS patients, and assessed the correlation between HMGB1 serum levels and the use of disease ...
Zohara, Sternberg, Daniel, Sternberg, Trevor, Chichelli, Allison, Drake, Neel, Patel, Chana, Kolb, Kailash, Chadha, Jinhee, Yu, David, Hojnacki   +8 more
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The gesture life of high mobility group box 1

Current Opinion in Clinical Nutrition & Metabolic Care, 2003
Products of infection, ischemia, and injury stimulate the innate immune system to release proinflammatory cytokines, which act locally to activate specific cellular immune responses and initiate recovery. In pathological cases, however, cytokines are released systemically, resulting in progressive tissue injury, hypotension, organ dysfunction, or death.
Steven G, Friedman, Christopher J, Czura, Kevin J, Tracey   +2 more
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Identification and characterization of high mobility group box 1 and high mobility group box 2 in Siberian sturgeon (Acipenser baerii)

Gene, 2023
High mobility group box 1 (HMGB1) and high mobility group box 2 (HMGB2) were highly conserved nonhistone chromosomal proteins involved in DNA damage repair, innate immune and inflammatory response. In this study, Acipenser baerii HMGB1 (AbHMGB1) and HMGB 2 (AbHMGB2) were identified.
Lu, Lu, Shaotong, Dai, Lulu, Liu, Jiaxi, Liu, Xin, Zhang, Xiaoli, Huang, Ping, Ouyang, Yi, Geng, Zhiqiong, Li, Defang, Chen   +9 more
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Role of high mobility group box 1 in vitiligo

Menoufia Medical Journal, 2021
Objectives To assess the role of high-mobility group box 1 (HMGB1) in the pathogenesis of vitiligo patients and its relation to severity of vitiligo. Background Vitiligo is a chronic inflammatory disease characterized by skin depigmentation caused by the loss of epidermal melanocytes. Its prevalence ranges between 0.5 and 2%.
EmanEl-Sayed Ahmed Ghoniem, MohammedA Basha, EmanM. Abd Elgayed   +2 more
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High Mobility Group Box 1: An Immune-regulatory Protein

Current Gene Therapy, 2019
High mobility group box 1 (HMGB1) presents in almost all somatic cells as a component of the cell nucleus. It is necessary for transcription regulation during cell development. Recent studies indicate that extracellular HMGB1, coming from necrotic cells or activated immune cells, triggers inflammatory response whereas intracellular HMGB1 controls the ...
Jingjing Zhao, Tianle Sun, Shengdi Wu, Yufeng Liu   +3 more
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Nasal high‐mobility group box 1 and caspase in bronchiolitis

Pediatric Pulmonology, 2018
AbstractObjectiveNasal biomarkers have potential to add objectivity to the clinical assessment of the child with bronchiolitis. We aim to study, if nasal caspase and high‐mobility group box 1 protein (HMGB1) levels differ between patients who were hospitalized and those discharged from the emergency department (ED), among patients with bronchiolitis ...
Shu‐Ling Chong, Oi Fah Lai, Leodivica Castillo, Joo Guan Yeo, Nivedita Nadkarni, Oon Hoe Teoh, Jan Hau Lee   +6 more
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New high mobility group box 1 assay system

Clinica Chimica Acta, 2006
High-sensitivity sandwich ELISA methods have been developed using chemiluminescent substrates. HMGB1 (high mobility group box 1) protein has been shown to play a critical role in several inflammatory diseases and it may be involved in the development of atherosclerosis.Anti-human HMGB1 monoclonal antibodies and anti-peptide polyclonal antibodies ...
Shingo, Yamada, Keiko, Yakabe, Junichi, Ishii, Hitoshi, Imaizumi, Ikuro, Maruyama   +4 more
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Relevance of High‐Mobility Group Protein Box 1 to Neurodegeneration

2007
High-mobility group protein box 1 (HMGB1), also know as amphoterin, is a nonhistone nuclear protein with well-established functions in gene transcription and homeostasis regulation into the cell nucleus. Interestingly, the protein can be passively released in the extracellular space during necrosis, whereas retained into the nucleus by cells undergoing
Silvia, Fossati, Alberto, Chiarugi
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Role of high-mobility group box 1 in cancer.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022
High-mobility group box 1 (HMGB1) is a non-histone nuclear protein in most eukaryocytes. Inside the nucleus, HMGB1 plays an important role in several DNA events such as DNA repair, transcription, telomere maintenance, and genome stability. While outside the nucleus, it fulfils more complicated functions, including promoting cell proliferation ...
Juan, Xu, Pengzuo, Tao, Dongjin, Lü, Yu'e, Jiang, Quansong, Xia   +4 more
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