Results 41 to 50 of about 711,574 (300)

Chemical components analysis of handmade alcoholic beverages with special focus on psychoactive drugs as adulterants

open access: yesMethodsX
Handmade alcoholic beverages are produced in clandestine laboratories. There are reports concerning the of counterfeit alcoholic beverages adulterated with psychoactive drugs.
Morvarid Sadat Miri   +3 more
doaj   +1 more source

Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography.

open access: yesGenome Research, 1997
Y chromosome haplotypes are particularly useful in deciphering human evolutionary history because they accentuate the effects of drift, migration, and range expansion.
P. Underhill   +8 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Hemoglonbin Typing by High Performance Liquid Chromatography

open access: yesJournal of Associated Medical Sciences, 2015
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Thanusak Tatu, P Kaidkaseam, P Hathirat
doaj  

High rates of non-adherence to antihypertensive treatment revealed by high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS/MS) urine analysis

open access: yesHeart, 2014
Objectives Non-adherence to therapy is an important cause of suboptimal blood pressure control but few practical tools exist to accurately and routinely detect it.
M. Tomaszewski   +10 more
semanticscholar   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Fractionation of fecal neutral steroids by high performance liquid chromatography.

open access: yesJournal of Lipid Research, 1985
Fecal neutral steroids were fractionated by high performance liquid chromatography (HPLC) into three major fractions: 5 beta-H, 3-keto steroids; 5 beta-H, 3 beta-hydroxy steroids; and 5 alpha-H and delta 5-3 beta-hydroxy steroids.
E M Jackson   +3 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

Multidimensional High-Performance Liquid Chromatography [PDF]

open access: yes, 2011
This chapter explores alternative methods for obtaining chemical fingerprints, that being, multidimensional high-performance liquid chromatography (MDHPLC). HPLC is the most commonly used analytical separation technique for the determination of components in complex mixtures as it offers high sensitivity and can be highly selective.
Milroy, Coleen S. (R13959)   +3 more
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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