Results 41 to 50 of about 483,779 (311)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Development and validation of high-performance liquid chromatographic method for determination of ofloxacin and lomefloxacin in human plasma [PDF]

Journal of the Serbian Chemical Society, 2005
Ahigh-performance liquid chromatographicmethod for the determination of ofloxacin and lomefloxacin in human plasma has been developed and validated. The effect of organic modifiers on the retention of the investigated drugs was investigated.
Zendelovska Dragica, Stafilov Trajče
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Studi Degradasi Sediaan Infus Ciprofloksasin Menggunakan High Performance Liquid Chromatography

Jurnal Farmasi Sains dan Praktis, 2016
Penelitian ini menggambarkan perlakuan degradasi infus ciprofloksasin yang dikondisikan dengan pemanasan, penambahan asam dan basa. Produk degradasi dianalisis menggunaan perangkat HPLC merk Waters e2695 Separations, kolom SunFireTM C18, detektor PDA ...
Bekti Nugraheni
doaj   +1 more source

ESI-MS fragmentation pathways of some 1,2,4-triazole-3-thiones, the intermediate compounds in the synthesis of active pharmaceutical ingredients

Журнал органічної та фармацевтичної хімії, 2020
Aim. To determine the fragmentation pathways of eight 1,2,4-triazole-3-thiones, which are intermediate products in the synthesis of active pharmaceutical ingredients of potential and registered pharmaceutical formulations. Results and discussion. HPLC-
Borys O. Varynskyi, Andriy G. Kaplaushenko   +1 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Hemoglonbin Typing by High Performance Liquid Chromatography

Journal of Associated Medical Sciences, 2015
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Thanusak Tatu, P Kaidkaseam, P Hathirat
doaj  

Chemical components analysis of handmade alcoholic beverages with special focus on psychoactive drugs as adulterants

MethodsX
Handmade alcoholic beverages are produced in clandestine laboratories. There are reports concerning the of counterfeit alcoholic beverages adulterated with psychoactive drugs.
Morvarid Sadat Miri, Dariush Badakhshan, Maryam Akhgari, Masoud Ghadipasha   +3 more
doaj   +1 more source

High-performance liquid chromatography of Group 6 dimetal decacarbonyl complexes singly-bridged by diphosphine ligands

, 1994
The normal-phase high-performance liquid chromatography of a series of Group 6 dimetal decacarbonyl complexes, of the form (OC)5M(P(CH2)(n)P)M(CO)5, where M = Cr, Mo and W, and P(CH2)(n)P = diphenylphosphinyl bridge with n = 2-6, is reported ...
Hor, T. S A, Lee, H. K., Hor, T.S.A., Tan, K.-C., Tan, K. C., Lee, H.K.   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source