Results 51 to 60 of about 576,396 (225)

High resolution photoassociation spectroscopy of the excited c^{3}Σ_{1}^{+} potential of ^{23}Na^{133}Cs

Physical Review Research, 2023
We report on photoassociation spectroscopy probing the c^{3}Σ_{1}^{+} potential of the bialkali NaCs molecule, identifying 11 vibrational lines between v^{′}=0 and v^{′}=25 of the excited c^{3}Σ_{1}^{+} potential and fitting their rotational and ...
Lewis R. B. Picard, Jessie T. Zhang, William B. Cairncross, Kenneth Wang, Gabriel E. Patenotte, Annie J. Park, Yichao Yu, Lee R. Liu, Jonathan D. Hood, Rosario González-Férez, Kang-Kuen Ni   +10 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Strongly Depleted Methanol and Hypervolatiles in Comet C/2021 A1 (Leonard): Signatures of Interstellar Chemistry?

The Planetary Science Journal, 2023
We measured the chemical composition of comet C/2021 A1 (Leonard) using the long-slit echelle grating spectrograph iSHELL/IRTF on 2021 December 20 and on 2022 January 8 and 9.
Sara Faggi, Manuela Lippi, Michael J. Mumma, Geronimo L. Villanueva   +3 more
doaj   +1 more source

High resolution X-ray spectroscopy and imaging of Mrk573

, 2010
We present a detailed analysis of the XMM-Newton RGS high resolution X-ray spectra of the Seyfert 2 galaxy, Mrk573. This analysis is complemented by the study of the Chandra image, and its comparison to optical (HST) and radio (VLA) data.
Anders, Arnaud, Basko, Bell, Bianchi, Bianchi, Bianchi, Bianchi, Brinkman, Brown, Capetti, Cash, Daniel A. Evans, Dere, Dere, Dickey, Enrico Piconcelli, Evans, Falcke, Ferland, Ferruit, Fritz, Fruscione, Gabriel, Garmire, Giorgio Matt, Guainazzi, Guainazzi, Guainazzi, Hardcastle, Helou, House, Iwasawa, Kaastra, Kennicutt, Kinkhabwala, Korista, Li, Liedahl, Longair, Marco Chiaberge, Martini, Matt, Matt, Matteo Guainazzi, Moshir, Osterbrock, Porquet, Ranalli, Ranieri D. Baldi, Sako, Sambruna, Schlesinger, Schmitt, Stefano Bianchi, Strüder, Tilak, Turner, Turner, Ulvestad, Wilson, Young   +61 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Calibrating the Instrumental Drift in MAROON-X Using an Ensemble Analysis

The Astronomical Journal
MAROON-X is a state-of-the-art extreme-precision radial velocity spectrograph deployed on the 8.1 m Gemini-N telescope on Maunakea, Hawai’i. Using a stabilized Fabry–Pérot etalon for wavelength and drift calibration, MAROON-X has achieved a short-term ...
Ritvik Basant, Tanya Das, Jacob L. Bean, Rafael Luque, Andreas Seifahrt, Madison Brady, Nina Brown, Julian Stürmer, David Kasper, Guđmundur Stefánsson   +9 more
doaj   +1 more source

An Earth-sized Planet around an M5 Dwarf Star at 22 pc

The Astronomical Journal, 2023
We report on the discovery of an Earth-sized transiting planet ( R _p = 1.015 ± 0.051 R _⊕ ) in a P = 4.02 day orbit around K2-415 (EPIC 211414619), an M5V star at 22 pc.
Teruyuki Hirano, Fei Dai, John H. Livingston, Sascha Grziwa, Kristine W. F. Lam, Yui Kasagi, Norio Narita, Hiroyuki Tako Ishikawa, Kohei Miyakawa, Luisa M. Serrano, Yuji Matsumoto, Eiichiro Kokubo, Tadahiro Kimura, Masahiro Ikoma, Joshua N. Winn, John P. Wisniewski, Hiroki Harakawa, Huan-Yu Teng, William D. Cochran, Akihiko Fukui, Davide Gandolfi, Eike W. Guenther, Yasunori Hori, Kai Ikuta, Kiyoe Kawauchi, Emil Knudstrup, Judith Korth, Takayuki Kotani, Vigneshwaran Krishnamurthy, Tomoyuki Kudo, Takashi Kurokawa, Masayuki Kuzuhara, Rafael Luque, Mayuko Mori, Jun Nishikawa, Masashi Omiya, Jaume Orell-Miquel, Enric Palle, Carina M. Persson, Seth Redfield, Eugene Serabyn, Alexis M. S. Smith, Aoi Takahashi, Takuya Takarada, Akitoshi Ueda, Vincent Van Eylen, Sébastien Vievard, Motohide Tamura, Bun’ei Sato   +48 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

LiYF4:Ho crystal in a magnetic field: high resolution optical spectroscopy

EPJ Web of Conferences, 2017
Low-temperature high-resolution optical spectra of LiYF4:Ho in an external magnetic field H are presented. A field-dependent transformation of the hyperfine structure of holmium spectral lines is studied for the cases H||c and H┴c.
Boldyrev K.N., Popova M.N.
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source