Results 91 to 100 of about 709,711 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hubungan Antara Whr Dengan Kadar Hs-crp Serum Pada Mahasiswa Obes Dan Tidak Obes Di Fakultas Kedokteran Universitas Sam Ratulangi Manado [PDF]

open access: yes, 2013
: Central obesity is recognized as a major factor that associated with increased risk for some chronic diseases. Waist to hip ratio described the increase in visceral adipose tissue and subcutaneous fat on waist circumference and hip circumference.C ...
Bolang, A. S. (Alexander)   +2 more
core  

High-Sensitivity C-Reactive Protein and Cardiovascular Disease

open access: yesCardiovascular Journal, 1970
DOI: http://dx.doi.org/10.3329/cardio.v3i2.9188Cardiovasc. J.
MU Ahmed, MK Mohsin
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Within-subject variation of C-reactive protein and high-sensitivity C-reactive protein: A systematic review and meta-analysis.

open access: yesPLoS ONE
BackgroundC-reactive protein (CRP) and high-sensitivity C-reactive protein (hsCRP) are measures of inflammation used in diagnosis, to guide treatment decisions, and in disease prediction.
Alex Gough   +3 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

High-Sensitivity C-Reactive Protein and Cardiovascular Disease Across Countries and Ethnicities

open access: yesClinics, 2016
Despite substantial differences in ethnicities, habits, cultures, the prevalence of traditional cardiovascular risk factors and affordable therapies, atherosclerosis remains the major cause of death in developing and developed countries.
Francisco Antonio Helfenstein Fonseca   +1 more
doaj   +1 more source

How useful is high-sensitivity CRP as a risk factor for coronary artery disease? [PDF]

open access: yes, 2005
Little evidence supports the use of the high-sensitivity C-reactive protein assay (hs-CRP) as a screening test for cardiovascular disease (CVD) in the healthy adult population. There is significant debate about its use in populations at moderate risk for
Collins, Linda J., Hull, Sharon K.
core  

Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study [PDF]

open access: yes, 2016
Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to ...
Atkin, Stephen L.   +5 more
core   +1 more source

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