Results 71 to 80 of about 34,699,913 (290)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Association of Three Novel Inflammatory Markers: Lymphocyte to HDL‐C Ratio, High‐Sensitivity C‐Reactive Protein to HDL‐C Ratio and High‐Sensitivity C‐Reactive Protein to Lymphocyte Ratio With Metabolic Syndrome

Endocrinology, Diabetes & Metabolism
Objective We aimed to compare the association of three novel inflammatory indicators with metabolic syndrome (MetS) among Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort participants.
Rana Kolahi Ahari, Nazanin Akbari, Negin Babaeepoor, Zahra Fallahi, Sara Saffar Soflaei, Gordon Ferns, Mahmoud Ebrahimi, Mohsen Moohebati, Habibollah Esmaily, Majid Ghayour‐Mobarhan   +9 more
doaj   +1 more source

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability [PDF]

, 2005
Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
Stidwill, RP, Singer, M, MacAllister, RJ, Storry, C, Pepys, MB, Vallance, P, Deanfield, JE, Hineorani, AD, Clapp, BR, Hirschfield, GM, Gallimore, JR   +10 more
core  

Predictive value of high sensitivity C-reactive protein on progression to heart failure occurring after the first myocardial infarction

Vascular Health and Risk Management, 2019
Zohair A Al Aseri,1 Syed Shahid Habib,2 Ameer Marzouk31Department of Emergency Medicine, King Saud University & Medical City, Riyadh, Saudi Arabia; 2Department of Physiology, King Saud University & Medical City, Riyadh, Saudi Arabia; 3College of ...
Al Aseri ZA, Habib SS, Marzouk A
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Functional activities of C-reactive protein on neutrophils [PDF]

C-reactive protein (CRP) is a member of the pentraxin family which opsonises S. pneumoniae through its binding to phosphorylcholine. In addition, CRP binds to Fcγ receptors: FcγRI with high affinity and, probably, FcγRIIA with lower affinity.
Rodriguez, Jairo Antonio
core   +1 more source

Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease [PDF]

, 2010
Background: Systematic evaluations of the quality of research on a single prognostic biomarker are rare. We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events ...
Adam D Timmis, Kate S L McAllister, Fitzpatrick Natalie K., J. Damant (7608818), Stephen Palmer, McAllister, Kate, Aroon D Hingorani, A. D. Timmis (7608830), Hingorani, AD, Chen Ruoling, A. D. Hingorani (7602500), Damant Jacqueline, Fitzpatrick, NK, Timmis Adam D., Keith R. Abrams, J. C. Kaski (7608827), Palmer, S, Fitzpatrick, Natalie K., Chen, Ruoling, Abrams, Keith R, Harry Hemingway, Timmis, Adam D, Philipson, P, Santiago Moreno, Natalie K. Fitzpatrick, Palmer, Stephen, Turnbull, Fiona Mary, McAllister, Kate S L, Damant, J, Timmis, Adam D., K. S. L. McAllister (7608824), Moreno, Santiago, Kaski, JC, Philipson Peter, Hingorani, Aroon D, Hemingway Harry, Adam D. Timmis, Fitzpatrick, Natalie K, Abrams Keith R., Keith R. Abrams (7579436), Shipley, Martin, Palmer Stephen, Hemingway, Harry, Shipley Martin, Abrams, Keith R., Chen, R, H. Hemingway (7608809), McAllister, KSL, Shipley, M, Timmis, AD, Moreno Santiago, Natalie K Fitzpatrick, Hingorani Aroon D., Damant, Jacqueline, Juan Carlos Kaski, Fitzpatrick, Natalie, Philipson, Peter, McAllister, KS, N. K. Fitzpatrick (7608815), Kaski Juan Carlos, P. Philipson (7608812), Abrams, Keith, Kate S. L. McAllister, S. Palmer (3693193), Martin Shipley, Peter Philipson, Jacqueline Damant, M. Shipley (7608821), McAllister Kate S. L., Santiago Moreno (90184), Chen, RL, Moreno, S, Mcallister, Katherine, Abrams, KR, R. Chen (576618), Hingorani, Aroon D., Kaski, Juan Carlos, Keith R Abrams, Hemingway, H, Timmis, Adam, Aroon D. Hingorani, Ruoling Chen, Philipson, Pete, Hingorani, Aroon   +83 more
core   +1 more source

Long-Term Trajectories of High-Sensitivity C-Reactive Protein Level Among Patients with Acute Heart Failure

Journal of Inflammation Research, 2023
Guangda He,1 Runqing Ji,1 Xiqian Huo,1 Xiaoming Su,1 Jinzhuo Ge,1 Wei Li,1 Lubi Lei,1 Boxuan Pu,1 Aoxi Tian,1 Jiamin Liu,1 Lihua Zhang,1 Yongjian Wu2 On behalf of the China PEACE Collaborative Group1National Clinical Research Center for Cardiovascular ...
He G, Ji R, Huo X, Su X, Ge J, Li W, Lei L, Pu B, Tian A, Liu J, Zhang L, Wu Y   +11 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source