Results 261 to 270 of about 1,151,593 (279)
Some of the next articles are maybe not open access.
High-throughput mouse phenotyping
Methods, 2011Comprehensive phenotyping will be required to reveal the pleiotropic functions of a gene and to uncover the wider role of genetic loci within diverse biological systems. The challenge will be to devise phenotyping approaches to characterise the thousands of mutants that are being generated as part of international efforts to acquire a mutant for every ...
Muller, Werner +3 more
openaire +4 more sources
High-throughput protein crystallization
Journal of Structural Biology, 2003High-throughput structural biology is a focus of a number of academic and pharmaceutical laboratories around the world. The use of X-ray crystallography in these efforts is critically dependent on high-throughput protein crystallization. The application of current protocols yields crystal leads for approximately 30% of the input proteins and well ...
Raymond, Hui, Aled, Edwards
openaire +2 more sources
2009
Surface plasmon resonance (SPR) imaging technique is label free, real-time, and high-throughput analysis method for interaction studies with array format. The application of SPR imaging for the small molecule arrays, which were fabricated by photoaffinity crosslinking, can be the first screening step for reverse chemical genomics.
Motoki, Kyo +3 more
openaire +2 more sources
Surface plasmon resonance (SPR) imaging technique is label free, real-time, and high-throughput analysis method for interaction studies with array format. The application of SPR imaging for the small molecule arrays, which were fabricated by photoaffinity crosslinking, can be the first screening step for reverse chemical genomics.
Motoki, Kyo +3 more
openaire +2 more sources
High-throughput discovery metabolomics
Current Opinion in Biotechnology, 2015Non-targeted metabolomics by mass spectrometry has established as the method of choice for investigating metabolic phenotypes in basic and applied research. Compared to other omics, metabolomics provides broad scope and yet direct information on the integrated cellular response with low demand in material and sample preparation.
Tobias, Fuhrer, Nicola, Zamboni
openaire +2 more sources
High-throughput protein crystallization
Current Opinion in Structural Biology, 2000The combinatorial chemistry industry has made major advances in the handling and mixing of small volumes, and in the development of robust liquid-handling systems. In addition, developments have been made in the area of material handling for the high-throughput drug screening and combinatorial chemistry fields.
openaire +2 more sources
High-Throughput Crystallization Screening
2014Protein structure determination by X-ray crystallography is dependent on obtaining a single protein crystal suitable for diffraction data collection. Due to this requirement, protein crystallization represents a key step in protein structure determination.
Tatiana, Skarina +3 more
openaire +2 more sources
High-Throughput Protein Crystallization
2009Structural genomics projects have led to great progress in the field of structural biology. Considerable advances have been made in the automation of all stages of the pipeline from clone to structure. This chapter focuses on crystallization that is one of the major bottlenecks in this pipeline.
openaire +2 more sources
High-throughput antibody production
Current Opinion in Chemical Biology, 2005Proteome-wide sets of antibodies would be an invaluable research resource for use in highly parallel assays such as microarrays. Such assays could provide deeper insights into biology and a wealth of information for clinical diagnostics. However, the rate of discovery of new proteins far exceeds the antibody supply currently produced from traditional ...
openaire +2 more sources
High throughput genotyping technologies
Briefings in Functional Genomics and Proteomics, 2002A comprehensive genetic map containing several hundred microsatellite markers resulted from a large microsatellite mapping project. This was the first real study that introduced high throughput methods to the genetic community. This map and the concurrent technological advances, which will briefly be reviewed, led to further numerous mapping ...
openaire +2 more sources