Genetic landscape of myelodysplastic syndrome and its prognostic relevance: a study from Pakistan
Journal of the Pakistan Medical AssociationObjective: To determine the genetic landscape of myelodysplastic syndrome patients, and to evaluate the impact of gene mutations on disease prognosis and overall survival.
Alia Waheed +5 more
doaj +1 more source
"Sequencing-grade" screening for
Journal of Translational Medicine, 2008 The need for fast, efficient, and less costly means to screen genetic variants associated with disease predisposition led us to develop an oligo-nucleotide array-based process for gene-specific single nucleotide polymorphism (SNP) genotyping.
Fasano Ross +8 more
doaj +1 more source
Relationships among the nucleotide content of human genome sequence, gene structure, and gene expression features (PhD synopsis) [PDF]
arXiv, 2010 The Dissertation is focused on the studies of associations between functional elements in human genome and their nucleotide structure. The asymmetry in nucleotide content (skew, bias) was chosen as the main feature for nucleotide structure. A significant difference in nucleotide content asymmetry was found for human exons vs. introns.
arxiv
High, clustered, nucleotide diversity in the genome of Anopheles gambiae revealed through pooled-template sequencing: implications for high-throughput genotyping protocols [PDF]
, 2009 Craig S. Wilding +3 more
openalex +1 more source
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
Advanced Science, EarlyView.The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan +16 more
wiley +1 more source
CRISPR-sub: Analysis of DNA substitution mutations caused by CRISPR-Cas9 in human cells
Computational and Structural Biotechnology Journal, 2020 CRISPR-Cas9 induces DNA cleavages at desired target sites in a guide RNA-dependent manner; DNA editing occurs through the resulting activity of DNA repair processes including non-homologous end joining (NHEJ), which is dominant in mammalian cells.
Gue-Ho Hwang +7 more
doaj
Large scale single nucleotide polymorphism discovery in unsequenced genomes using second generation high throughput sequencing technology: applied to turkey [PDF]
, 2009 Hindrik H. D. Kerstens +6 more
openalex +1 more source
Advanced Science, EarlyView.This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang +8 more
wiley +1 more source
Triander: A new program for visual analysis of nucleotide sequences [PDF]
Factors Exp. Evol. Organisms (Ed. V.A. Kunah, Inst. Mol. Biol.
Genetics, Kyiv: Lohos), vol. 17 (2015), p. 51-54, 2015 The Triander program is an interactive software package for nucleotide sequence visualization. The program was developed using the freeware Pascal RAD IDE Lazarus, and its source code and binaries compiled for Windows are freely accessible at http://www.icbge.org.ua/eng/Triander . Triander can produce four types of plots.
arxiv
Advanced Science, EarlyView.The research findings indicate that dimethyl itaconate (DI) alleviates Escherichia coli (E. coli) induced endometritis by modulating the gut microbiota and enriching the abundance of norank_f_Muribaculaceae, thereby increasing the production of guanosine.
Yuhang He +6 more
wiley +1 more source