Results 91 to 100 of about 213,884 (275)

A bioinformatics approach to microRNA-sequencing analysis

Osteoarthritis and Cartilage Open, 2021
The rapid expansion of Next Generation Sequencing (NGS) data availability has made exploration of appropriate bioinformatics analysis pipelines a timely issue.
Pratibha Potla, Shabana Amanda Ali, Mohit Kapoor   +2 more
doaj  

A High-Throughput Data Mining of Single Nucleotide Polymorphisms inCoffeaSpecies Expressed Sequence Tags Suggests Differential Homeologous Gene Expression in the AllotetraploidCoffea arabica [PDF]

Plant Physiology, 2010
AbstractPolyploidization constitutes a common mode of evolution in flowering plants. This event provides the raw material for the divergence of function in homeologous genes, leading to phenotypic novelty that can contribute to the success of polyploids in nature or their selection for use in agriculture.
Marcelo Falsarella Carazzolle, Luiz Gonzaga Esteves Vieira, Alan Carvalho Andrade, Jorge Maurício Costa Mondego, David Pot, Ramon O. Vidal, Gonçalo Amarante Guimarães Pereira, Luiz Filipe Protasio Pereira, Alinne Batista Ambrosio, Carlos Augusto Colombo   +9 more
openaire   +3 more sources

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Synthetic spike-in standards for high-throughput 16S rRNA gene amplicon sequencing

Nucleic Acids Research, 2016
High-throughput sequencing of 16S rRNA gene amplicons (16S-seq) has become a widely deployed method for profiling complex microbial communities but technical pitfalls related to data reliability and quantification remain to be fully addressed.
Dieter M. Tourlousse, Satowa Yoshiike, Akiko Ohashi, S. Matsukura, N. Noda, Y. Sekiguchi   +5 more
semanticscholar   +1 more source

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development

Advanced Science, EarlyView.
Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang   +14 more
wiley   +1 more source

Quantitative Super‐Resolution Imaging of Molecular Tension

Advanced Science, EarlyView.
Quantitative tension PAINT (qtPAINT) is a new method to quantify molecular tension at super‐resolution by exploiting force‐dependent DNA oligonucleotide dissociation kinetics. Combining hairpin tension probes and molecular‐beacon imagers, qtPAINT achieves 9–30 pN continuous force quantification range with 30–120 nm spatial and minute‐scale temporal ...
Seong Ho Kim, Adam B. Yasunaga, Hongyuan Zhang, Kevin D. Whitley, Isaac T. S. Li   +4 more
wiley   +1 more source

Additional file 1: of Quantification of experimentally induced nucleotide conversions in high-throughput sequencing datasets

, 2019
Supplementary information, figures and tables. (PDF 6280 kb)
Neumann, Tobias, Herzog, Veronika, Muhar, Matthias, Haeseler, Arndt, Zuber, Johannes, Ameres, Stefan, Rescheneder, Philipp   +6 more
openaire   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Identification of intragenic variants in pediatric patients with intellectual disability in Peru

BMC Medical Genomics
Background Intellectual disability in Latin America can reach a frequency of 12% of the population, these may include nutritional deficiencies, exposure to toxic or infectious agents, and the lack of universal neonatal screening programs.
Hugo Hernán Abarca-Barriga, Flor Vásquez Sotomayor, Renzo Punil-Luciano, María Cristina Laso-Salazar, Heli Jaime Barrón-Pastor   +4 more
doaj   +1 more source

Metagenome sequencing-based strain-level and functional characterization of supragingival microbiome associated with dental caries in children

Journal of Oral Microbiology, 2019
Studies of the microbiome associated with dental caries have largely relied on 16S rRNA sequence analysis, which is associated with PCR biases, low taxonomic resolution, and inability to accurately study functions.
Nezar Noor Al-Hebshi, Divyashri Baraniya, Tsute Chen, Jennifer Hill, Sumant Puri, Marisol Tellez, Nur A. Hasan, Rita R. Colwell, Amid Ismail   +8 more
doaj   +1 more source