Results 131 to 140 of about 229,759 (254)

High-throughput amplicon sequencing of the full-length 16S rRNA gene with single-nucleotide resolution [PDF]

, 2019
Benjamin J. Callahan, Joan Wong, Cheryl Heiner, Steve D. Oh, Casey M. Theriot, Ajay Gulati, Sarah McGill, Michael Dougherty   +7 more
openalex   +1 more source

Development of a single‐nucleotide polymorphism panel genotyping system for genetic analysis of Chinese hamsters

Animal Models and Experimental Medicine, EarlyView.
Here, we developed a novel Chinese hamster genetic quality detection system using single‐nucleotide polymorphism (SNP) markers following this process. To obtain SNP loci, we conducted whole genome sequencing on 24 Chinese hamsters. Then, we employed an SNP loci screening criterion that we set up previously and initially screened 214 SNP loci with wide ...
Minghe Sun, Yafang Guo, Zhengnan Ren, Ang Song, Jing Lu, Changlong Li, Jianyi Lv, Meng Guo, Xin Liu, Xiaoyan Du, Zhaoyang Chen, Guohua Song, Yan He, Zhenwen Chen, Xueyun Huo   +14 more
wiley   +1 more source

Using single molecule Molecular Inversion Probes as a cost‐effective, high‐throughput sequencing approach to target all genes and loci associated with macular diseases

Human Mutation, Volume 43, Issue 12, Page 2234-2250, December 2022., 2022
Abstract Macular degenerations (MDs) are a subgroup of retinal disorders characterized by central vision loss. Knowledge is still lacking on the extent of genetic and nongenetic factors influencing inherited MD (iMD) and age‐related MD (AMD) expression.
Rebekkah J. Hitti‐Malin, Claire‐Marie Dhaenens, Daan M. Panneman, Zelia Corradi, Mubeen Khan, Anneke I. den Hollander, G. Jane Farrar, Christian Gilissen, Alexander Hoischen, Maartje van de Vorst, Femke Bults, Erica G. M. Boonen, Patrick Saunders, MD Study Group, Susanne Roosing, Frans P. M. Cremers   +15 more
wiley   +1 more source

Identification of the Micro‐Ribonucleic Acid Profiles of Plant‐Derived Extracellular Vesicles and their Potential Crosskingdom Regulation

Advanced NanoBiomed Research, EarlyView.
The present study employs small RNA sequencing to identify the types and content of microRNAs (miRNAs) in four widely utilized plant‐derived extracellular vesicles (pEVs). The functional annotation reveals that the pEV miRNAs are involved in regulating the progression of human cancer and viral infection, thereby demonstrating the crosskingdom ...
Fei Wang, Junyao Deng, Shushan Mo, Jiacong Ai, Yingxian Xiao, Xiaohan Zhou, Zhenhua Li, Lanya Li   +7 more
wiley   +1 more source

SPiP: Splicing Prediction Pipeline, a machine learning tool for massive detection of exonic and intronic variant effects on mRNA splicing

Human Mutation, Volume 43, Issue 12, Page 2308-2323, December 2022., 2022
Abstract Modeling splicing is essential for tackling the challenge of variant interpretation as each nucleotide variation can be pathogenic by affecting pre‐mRNA splicing via disruption/creation of splicing motifs such as 5′/3′ splice sites, branch sites, or splicing regulatory elements.
Raphaël Leman, Béatrice Parfait, Dominique Vidaud, Emmanuelle Girodon, Laurence Pacot, Gérald Le Gac, Chandran Ka, Claude Ferec, Yann Fichou, Céline Quesnelle, Camille Aucouturier, Etienne Muller, Dominique Vaur, Laurent Castera, Flavie Boulouard, Agathe Ricou, Hélène Tubeuf, Omar Soukarieh, Pascaline Gaildrat, Florence Riant, Marine Guillaud‐Bataille, Sandrine M. Caputo, Virginie Caux‐Moncoutier, Nadia Boutry‐Kryza, Françoise Bonnet‐Dorion, Ines Schultz, Maria Rossing, Olivier Quenez, Louis Goldenberg, Valentin Harter, Michael T. Parsons, Amanda B. Spurdle, Thierry Frébourg, Alexandra Martins, Claude Houdayer, Sophie Krieger   +35 more
wiley   +1 more source

Ten simple rules for managing high-throughput nucleotide sequencing data

, 2016
Rutger Vos
openalex   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Accepted Article.
Supported by rapid technological advancements, biocatalytic applications have matured into a sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon‐carbon frameworks and multiple ...
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe Bornscheuer   +4 more
wiley   +1 more source

Thyroid‐like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Integrated Environmental Assessment and Management, Volume 19, Issue 1, Page 63-82, January 2023., 2023
Abstract This review examines the presence and evolution of thyroid‐like systems in selected aquatic invertebrates to determine the potential use of these organisms in screens for vertebrate thyroid hormone axis disrupting chemicals (THADCs). Such a screen might support the phasing out of some vertebrate testing.
Jane E. Morthorst, Henrik Holbech, Noémie De Crozé, Peter Matthiessen, Gerald A. LeBlanc   +4 more
wiley   +1 more source

More affordable and effective noninvasive single nucleotide polymorphism genotyping using high‐throughput amplicon sequencing [PDF]

, 2020
Charlotte E. Eriksson, Joel Ruprecht, Taal Levi   +2 more
openalex   +1 more source

Systemic circulating microRNA landscape in Lynch syndrome

International Journal of Cancer, Volume 152, Issue 5, Page 932-944, 1 March 2023., 2023
What's new? Systemic circulating microRNA expression patterns (c‐miRnomes) are altered during sporadic carcinogenesis and they have predictive potential in early cancer detection. However, their potential in carriers of inherited pathogenic mismatch‐repair gene variants associated with Lynch syndrome remains understudied.
Tero Sievänen, Tia‐Marje Korhonen, Tiina Jokela, Maarit Ahtiainen, Laura Lahtinen, Teijo Kuopio, Anna Lepistö, Elina Sillanpää, Jukka‐Pekka Mecklin, Toni T. Seppälä, Eija K. Laakkonen   +10 more
wiley   +1 more source