Results 211 to 220 of about 153,654 (268)

Research note: Virome of Alectoris chukars by metagenomic analysis in Guangdong, southern China. [PDF]

Poult Sci
Chen J, Li J, Lin Z, Zhang Y, Lin L, Guo S, Huang S, Li X, Ma J.   +8 more
europepmc   +1 more source

Decoding temporal miRNA signatures of semen under in vitro exposure for forensic time since deposition estimation using machine learning‐driven modeling

Interdisciplinary Medicine, EarlyView.
This study develops a novel miRNA‐based framework for estimating the time since deposition of semen stains, combining small RNA sequencing with machine learning. Time‐dependent miRNA modules were identified using Mfuzz clustering and WGCNA, followed by a multi‐stage feature selection pipeline that reduced 261 candidate miRNAs to a minimal 7‐miRNA panel.
Meiming Cai, Qiong Lan, Tong Xie, Qinglin Liu, Ming Zhao, Xiaolian Wu, Xin Shi, Ruonan Shen, Yiman Wu, Chen Mao, Bin Cong, Bofeng Zhu   +11 more
wiley   +1 more source

NanoMLST: A High-Throughput Bacterial Multi-Locus Sequence Typing Workflow Using Oxford Nanopore Next-Generation Sequencing for ESKAPE + E Pathogens. [PDF]

Microbiologyopen
García-Pérez I, Lázaro-Perona F, Reyes-Zuñagua DS, Sotelo J, Rodríguez-Tejedor M, Cañada-García JE, Bloise I, Portugués-Rodríguez SM, Mingorance J, Oteo-Iglesias J, Dahdouh E.   +10 more
europepmc   +1 more source

Human Breast Milk‐Derived Exosomal FP671120.4 Inhibits Macrophage M1 Polarization via Modulating the ELAVL1/Nrf2 Axis in Sepsis‐Associated Liver Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐associated liver injury (SALI) plays a major role in aggravating disease progression and worsening prognosis in patients with sepsis. Macrophage polarization is a key factor in the modulation of SALI progression. Recent studies have shown that human breast milk‐derived exosomes (HBM‐Exos) regulate processes involved in macrophage ...
Zhao‐Bin Yang, Yi‐Bin Gao, Xiao‐Mei Cheng, Lu‐Zhen Qiu   +3 more
wiley   +1 more source

Single-particle genomics uncovers abundant non-canonical marine viruses from nanolitre volumes. [PDF]

Nat Microbiol
Weinheimer AR, Brown JM, Thompson B, Leonaviciene G, Kiseliovas V, Jocys S, Munson-McGee J, Gavelis G, Mascena C, Mazutis L, Poulton NJ, Zilionis R, Stepanauskas R.   +12 more
europepmc   +1 more source

Improved COI taxonomic assignment workflow enhances detection of invertebrates in environmental DNA

Limnology and Oceanography: Methods, EarlyView.
Abstract Environmental DNA (eDNA) metabarcoding is an increasingly popular and powerful tool in ecology, offering a non‐invasive method to assess biodiversity and monitor ecosystem health across diverse environments. While the mitochondrial cytochrome c oxidase subunit I (COI) gene is one of the most widely used markers for studying eukaryotic ...
Yuanyu Cheng, David Walsh, Joanna Gauthier, Marie‐Eve Monchamp, Daniel T. Selbie, Irene Gregory‐Eaves   +5 more
wiley   +1 more source

High-Throughput Sequencings Revealed That Gut Microbiota Dysbiosis is Implicated in Gouty Arthritis of Red-Crowned Crane (<i>Grus japonensis</i>). [PDF]

Transbound Emerg Dis
Lin H, Zhu X, Zhu J, Chen N, Bao W, Peng Z.   +5 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Whole genome sequencing of hepatitis A virus: adapting Illumina protocols for foodborne investigation. [PDF]

NPJ Sci Food
Yeo D, Jung S, Hwang S, Yoon D, Lim DJ, Jin S, Choi J, Hong KH, Choi C.   +8 more
europepmc   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, EarlyView.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source