Results 221 to 230 of about 271,712 (303)

RUMINA: high-throughput deduplication of unique molecular identifiers for amplicon and whole-genome sequencing with enhanced error correction. [PDF]

Bioinformatics
Piliper E, Goya S, Greninger AL.
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Unlocking the full potential of nanopore sequencing: tips, tricks, and advanced data analysis techniques. [PDF]

Nucleic Acids Res
Meyer D, Goettsch W, Spangenberg J, Stieber B, Krautwurst S, Hölzer M, Brandt C, Linde J, Höner Zu Siederdissen C, Srivastava A, Zarkovic M, Wollny D, Marz M.   +12 more
europepmc   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

zDUR: reference-free FASTQ compressor with high compression ratio and speed. [PDF]

BMC Bioinformatics
Ershov A, Ding R, Fu Q, Kozlov I, Fadeeva E, Mozheiko E, Ni M, Hou Y, Zhou Y.   +8 more
europepmc   +1 more source

Development and Validation of a Consensus Machine Learning–Derived Signature to Predict Survival and Treatment Benefits in Breast Cancer

Medicine Advances, EarlyView.
The consensus machine learning–derived prognostic signature (CMDPS) was developed by integrating 10 independent breast cancer cohorts and 76 algorithm combinations, which identified 19 robust survival‐associated genes. The CMDPS demonstrated superior prognostic performance compared to clinical features and 62 published transcriptome signatures ...
Guangyang Cheng, Zhan Wang, Fu Peng, Shuai Yang, Yudi Xu, Hongzhuo Qin, Run Shi, Zhaokai Zhou   +7 more
wiley   +1 more source

AI-powered analysis of viral metagenomic sequencing data for rapid outbreak investigation and novel pathogen discovery. [PDF]

Front Microbiol
Chisompola D, Luwaya E, Nzobokela J, Mwansa P, Chakulya M.   +4 more
europepmc   +1 more source

Correcting nucleotide-specific biases in high-throughput sequencing data

, 2019
Jeremy Wang, Bryan C. Quach, Terrence S. Furey   +2 more
openalex   +1 more source

Defense heterosis as a novel plant protection strategy: From theory to breeding practice

New Plant Protection, EarlyView.
Defense heterosis, the enhanced disease resistance of hybrids compared to their parents, has evolved from early observations of hybrid vigor to a novel research concept. Advances are now clarifying its diverse genetic and molecular mechanisms across various plant–pathogen interactions.
Kaiqi Xu, Xue Li, Fangfang Li
wiley   +1 more source

Methodological Assessment of High-Throughput Sequencing Platforms: Illumina vs. MGI in Clinical-Grade <i>CFTR</i> Genotyping. [PDF]

Int J Mol Sci
Beggio M, Peroni E, Greco E, Favretto G, Degiorgio D, Rosato A, Favarato M.   +6 more
europepmc   +1 more source