Results 51 to 60 of about 271,712 (303)

Intervention of next-generation sequencing in diagnosis of Alzheimer’s disease: challenges and future prospects [PDF]

Dementia & Neuropsychologia, 2023
Clinical diagnosis of several neurodegenerative disorders based on clinical phenotype is challenging due to its heterogeneous nature and overlapping disease manifestations.
Tijimol Chandy
doaj   +1 more source

Identification of New Single Nucleotide Polymorphisms Potentially Related to Small Ruminant Lentivirus Infection Susceptibility in Goats Based on Data Selected from High-Throughput Sequencing [PDF]

Pathogens
Small ruminant lentivirus (SRLV) infections are spread in the flocks of sheep and goats all over the world, causing economic loss. Although only a fraction of infected animals develop disease symptoms, all of them may shed the virus, causing uncontrolled spread of the infection.
Magdalena Materniak-Kornas, Katarzyna Ropka‐Molik, Katarzyna Piórkowska, Joanna Kowalik, Tomasz Szmatoła, Jacek Sikora, Aldona Kawęcka, Jacek Kuźmak   +7 more
openalex   +4 more sources

Applications of next-generation sequencing technologies and computational tools in molecular evolution and aquatic animals conservation studies : a short review [PDF]

, 2019
Aquatic ecosystems that form major biodiversity hotspots are critically threatened due to environmental and anthropogenic stressors. We believe that, in this genomic era, computational methods can be applied to promote aquatic biodiversity conservation ...
Afiqah-Aleng, Nor, Danish-Daniel, Muhd, Mohd Nor, Siti Azizah, Razali, Siti Aisyah, Sorgeloos, Patrick, Sung, Yeong Yik, Tan, Min Pau, Van de Peer, Yves, Wong, Li Lian   +8 more
core   +1 more source

Genetic, Clinicopathological, and Radiological Features of Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation Pattern

Gut and Liver, 2022
Background/Aims: Intrahepatic cholangiocarcinoma (iCCA) with a ductal plate malformation (DPM) pattern is a recently recognized rare variant. The genomic profile of iCCA with DPM pattern needs to be elucidated.
Taek Chung, Hyungjin Rhee, Hyo Sup Shim, Jeong Eun Yoo, Gi Hong Choi, Haeryoung Kim, Young Nyun Park   +6 more
doaj   +1 more source

Capturing the ‘ome’ : the expanding molecular toolbox for RNA and DNA library construction [PDF]

, 2018
All sequencing experiments and most functional genomics screens rely on the generation of libraries to comprehensively capture pools of targeted sequences.
Boone, Morgane, Callewaert, Nico, De Koker, Andries   +2 more
core   +2 more sources

Genome-wide SNP typing of ancient DNA: Determination of hair and eye color of Bronze Age humans from their skeletal remains. [PDF]

, 2020
Objective A genome-wide high-throughput single nucleotide polymorphism (SNP) typing method was tested with respect of the applicability to ancient and degraded DNA. The results were compared to mini-sequencing data achieved through single base extension (
Dörk, T., Hummel, S., Klintschar, M., Krause, I., Schmidt, N., Schücker, K.   +5 more
core   +2 more sources

A saturated genetic linkage map of autotetraploid alfalfa (Medicago sativa L.) developed using genotyping-by-sequencing is highly syntenous with the Medicago truncatula genome. [PDF]

, 2014
A genetic linkage map is a valuable tool for quantitative trait locus mapping, map-based gene cloning, comparative mapping, and whole-genome assembly. Alfalfa, one of the most important forage crops in the world, is autotetraploid, allogamous, and highly
Acharya, Ananta, Brummer, E Charles, Jiang, Qingzhen, Kang, Junmei, Li, Xuehui, Wei, Yanling   +5 more
core   +2 more sources

QQ-SNV: single nucleotide variant detection at low frequency by comparing the quality quantiles [PDF]

, 2015
Background: Next generation sequencing enables studying heterogeneous populations of viral infections. When the sequencing is done at high coverage depth ("deep sequencing"), low frequency variants can be detected.
Aerssens, Jeroen, Clement, Lieven, Reumers, Joke, Thys, Kim, van der Borght, Koen, van Vlijmen, Herman, Verbist, Bie, Wetzels, Yves   +7 more
core   +4 more sources

Single nucleotide variant detection in Jaffrabadi buffalo (Bubalus bubalis) using high-throughput targeted sequencing [PDF]

Frontiers in Life Science, 2015
The water buffalo is among the most important livestock species of southern Asia, contributing greatly to the ecosystem and rural livelihood of the region. The identification of large-scale single nucleotide polymorphisms in this species would greatly facilitate our understanding of the genetic basis of economically important traits such as milk ...
Maulik R. Upadhyay, Anand B. Patel, Ramalingam B. Subramanian, Tejas M. Shah, Subhash J. Jakhesara, Vaibhav D. Bhatt, Prakash G. Koringa, Dharamshibhai N. Rank, Chaitanya G. Joshi   +8 more
  +4 more sources

Quantifying evolutionary constraints on B cell affinity maturation

, 2014
The antibody repertoire of each individual is continuously updated by the evolutionary process of B cell receptor mutation and selection. It has recently become possible to gain detailed information concerning this process through high-throughput ...
Bedford, Trevor, Bradley, Philip, Matsen IV, Frederick A., McCoy, Connor O., Minin, Vladimir N., Robins, Harlan   +5 more
core   +2 more sources