Results 31 to 40 of about 1,236,846 (314)

High-Throughput Screening of Acyl-CoA Thioesterase I Mutants Using a Fluid Array Platform [PDF]

, 2019
Screening target microorganisms from a mutated recombinant library plays a crucial role in advancing synthetic biology and metabolic engineering. However, conventional screening tools have several limitations regarding throughput, cost, and labor.
Kim, Taesung, Lee, Sung Kuk, Lee, Yongjoo, Lim, Ji Won, Ryu, Young Shin, Shin, Kwang Soo   +5 more
core   +1 more source

EIF2S2 is a novel independent prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: Hepatocellular carcinoma (HCC) is a highly malignant disease with poor prognosis. It is urgent to find effective biomarkers. Eukaryotic Translation Initiation Factor 2 Subunit Beta (EIF2S2) is a subunit of heterotrimeric G protein EIF2, and ...
Jing Liu, Jing Liu, Tongyu Liu, Chuanhao Zhang, Chuanhao Zhang, Jiabei He, Jiabei He, Dong Zhou, Dong Zhou, Zhe Wang, Zhe Wang, Ruoyu Wang, Ruoyu Wang   +12 more
doaj   +1 more source

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses

Journal of Virology, 2019
Currently, there is no approved therapy to treat coronavirus infection; therefore, broad-spectrum inhibitors of emerging and endemic CoVs are needed. Based on our high-throughput screening assay using a compound library, we identified seven compounds ...
Liang Shen, J. Niu, Chunhua Wang, Baoying Huang, Wenling Wang, N. Zhu, Yao Deng, Huijuan Wang, F. Ye, S. Cen, W. Tan   +10 more
semanticscholar   +1 more source

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]

, 2013
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William, Cuda, F., Eccles, Suzanne A., Fox, Keith R., Hoakwie, Franciane, Lawrence, Charlotte, Male, Abigail, Miranda, Elena, Nordgren, Ida, Packham, Graham K., Tavassoli, Ali, Townsend, Paul   +11 more
core   +1 more source

Role of matrix metalloproteinases in diabetic foot ulcers: Potential therapeutic targets

Frontiers in Pharmacology, 2022
Diabetic foot ulcers (DFUs) are pathological states of tissue destruction of the foot or lower extremity in diabetic patients and are one of the serious chronic complications of diabetes mellitus.
Kang Fu, Xueyao Zheng, Yuhan Chen, Yuhan Chen, Liuying Wu, Liuying Wu, Zhiming Yang, Zhiming Yang, Xu Chen, Xu Chen, Wei Song, Wei Song   +11 more
doaj   +1 more source

High-throughput screening platform for solid electrolytes combining hierarchical ion-transport prediction algorithms

Scientific Data, 2020
The combination of a materials database with high-throughput ion-transport calculations is an effective approach to screen for promising solid electrolytes. However, automating the complicated preprocessing involved in currently widely used ion-transport
Bing He, Shuting Chi, Anjiang Ye, Penghui Mi, Liwen Zhang, Bowei Pu, Zheyi Zou, Yunbing Ran, Qian Zhao, Da Wang, Wenqing Zhang, Jingtai Zhao, S. Adams, M. Avdeev, S. Shi   +14 more
semanticscholar   +1 more source

Visual and computational analysis of structure-activity relationships in high-throughput screening data [PDF]

, 2001
Novel analytic methods are required to assimilate the large volumes of structural and bioassay data generated by combinatorial chemistry and high-throughput screening programmes in the pharmaceutical and agrochemical industries. This paper reviews recent
Agrafiotis, Agrafiotis, Ahlberg, Ajay, Ajay, Bayada, Bemis, Bernard, Bonabeau, Brown, Calvert, Card, Chen, Chen, Cho, Christianini, Clark, Clark, Cox, Duda, Edwards, Engels, Frimurer, Gao, Garrido, Ghose, Gillet, Gillet, Hand, Hann, Haupts, Hayward, Hertzberg, Izrailev, Jiang, Jones-Hertzog, Kirew, Kobayashi, Kohonen, Ladd, Lee, Lepre, Martin, Mason, Mello, Meyer, Miller, Mitchell, Oprea, Peter Gedeck, Peter Willett, Poroikov, Rhodes, Roberts, Roberts, Ros, Rusinko, Sadowski, Sadowski, Scherf, Sheridan, Shi, Stanton, Su, Teague, Thompson, Tropsha, Tufte, Tufte, Wagener, Walters, Wang, Wedin, Xie, Xu, Zupan   +75 more
core   +1 more source

Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening

Journal of Molecular Cell Biology, 2020
The recent advent of robust methods to grow human tissues as 3D organoids allows us to recapitulate the 3D architecture of tumors in an in vitro setting and offers a new orthogonal approach for drug discovery.
Yuhong Du, Xingnan Li, Qiankun Niu, Xiulei Mo, Min Qui, Tingxuan Ma, C. Kuo, H. Fu   +7 more
semanticscholar   +1 more source

A high-throughput screening method for determining the substrate scope of nitrilases [PDF]

, 2014
Nitrile compounds are intermediates in the synthesis of pharmaceuticals such as atorvastatin. We have developed a chromogenic reagent to screen for nitrilase activity as an alternative to Nessler's reagent. It produces a semi-quantifiable blue colour and
Black, Gary, Brown, Nicola, Perry, Justin, Randall, P. David, Turnbull, Graeme, Zhang, Meng   +5 more
core   +1 more source

A high-throughput human tissue model for respiratory viruses: Automating the use of human airway epithelial tissues for faster drug discovery

SLAS Discovery
Animal testing for drug discovery is expensive and the decision to test a compound in an in vivo model should be carefully considered. In addition, the FDA Modernization Act has resulted in the allowance of alternatives to animal models for testing the ...
N. Miranda Nebane, Andrew Reece, Lynn Rasmussen, Melinda Sosa, Pedro Ruiz, Sara M. Cabrera, Yohanka Martinez-Gzegozewska, Paige Vinson   +7 more
doaj   +1 more source