Results 41 to 50 of about 1,236,846 (314)
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]
, 2015 Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.Alonso-Padilla, Julio, Alvarez, Emilio, Bardera, Ana I., Barroso, Vanessa, Brown, James R., Cantizani, Juan, Colmenarejo, Gonzalo, Cotillo, Ignacio, de Dios-Anton, Francisco, Drewry, David H., Fiandor, Jose M., Gray, David W., Julio Martin, J., Kessler, Albane, Kumar, Vinod, Navarro, Miguel, Peña, Imanol, Pilar Manzano, M., Rodriguez, Ana, Roquero, Irene, Sherstnev, Alexander +20 morecore +3 more sourcesIterative focused screening with biological fingerprints identifies selective Asc-1 inhibitors distinct from traditional high throughput screening [PDF]
, 2017 N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and ...Amoss, Adam, Cassaday, Jason A., Cooke, Andrew J., Culberson, J. Chris, Finley, Michael, Hermes, Jeffrey D., Hurzy, Danielle, Johnson, Eric N., Kutchukian, Peter S., Magliaro, Brian C., O’Donnell, Gregory, Parmentier-Batteur, Sophie, Pascarella, Danette, Schlegel, Kelly-Ann Sondra, Squadroni, Brian, Thomson, Fiona, Uebele, Victor N., Warren, Lee, Zuck, Paul +18 morecore +2 more sourcesAI is a viable alternative to high throughput screening: a 318-target study
Scientific ReportsHigh throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space.Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho, Adrian Morrison, A. Stecula, Andreana Rosnik, Ann Marie O’Sullivan, Aram Davtyan, Ben Samudio, Bill Thomas, Brad Worley, Brittany Butler, Christian Laggner, Desiree Thayer, Ehsan Moharreri, Greg Friedland, Ha Truong, Henry van den Bedem, Ho Leung Ng, Kate Stafford, Krishna Sarangapani, Kyle Giesler, Lien Ngo, Michael Mysinger, Mostafa Ahmed, Nicholas J Anthis, Niel Henriksen, Pawel Gniewek, Sam Eckert, Saulo de Oliveira, Shabbir Suterwala, Srimukh Veccham Krishna PrasadPrasad, Stefani Shek, S. Contreras, Stephanie Hare, Teresa Palazzo, Terrence E. O’Brien, Tessa Van Grack, Tiffany Williams, Ting‐Rong Chern, Victor Kenyon, Andreia H. Lee, Andrew B. Cann, Bastiaan Bergman, Brandon M. Anderson, Bryan D. Cox, Jeffrey M. Warrington, Jon M. Sorenson, Joshua M. Goldenberg, Matthew A. Young, Nicholas DeHaan, Ryan P. Pemberton, S. Schroedl, Tigran M. Abramyan, Tushita Gupta, Venkatesh Mysore, Adam Presser, Adolfo A. Ferrando, A. Andricopulo, Agnidipta Ghosh, Aicha Gharbi Ayachi, Aisha Mushtaq, Ala M. Shaqra, Alan Kie Leong Toh, A. Smrcka, Alberto Ciccia, A. S. de Oliveira, A. Sverzhinsky, A. M. de Sousa, Alexander I. Agoulnik, Alexander Kushnir, Alexander N. Freiberg, Alexander V. Statsyuk, Alexandre R. Gingras, A. Degterev, Alexey Tomilov, A. Vrielink, A. Garaeva, Amanda Bryant-Friedrich, A. Caflisch, Amit K. Patel, A. Rangarajan, A. Matheeussen, Andrea Battistoni, Andrea Caporali, Andrea Chini, A. Ilari, Andrea Mattevi, Andrea Talbot Foote, A. Trabocchi, Andreas Stahl, Andrew B. Herr, Andrew Berti, A. Freywald, A. Reidenbach, Andrew Lam, A. Cuddihy, Andrew White, A. Taglialatela, Anil K. Ojha, Ann M. Cathcart, Anna A L Motyl, Anna M Borowska, Anna D'Antuono, Anna K H Hirsch, A. Porcelli, A. Minakova, A. Montanaro, Anna Müller, A. Fiorillo, A. Virtanen, A. O’Donoghue, Antonio Del Rio Flores, A. E. Garmendia, A. Pineda-Lucena, A. Panganiban, A. Samantha, A. Chatterjee, Arthur L. Haas, A. Paparella, Ashley L. St. John, Ashutosh Prince, Assmaa ElSheikh, A. Apfel, Audrey Colomba, Austin O’Dea, B. Diallo, B. M. R. M. Ribeiro, B. Bailey-Elkin, B. Edelman, B. Liou, Benjamin Perry, B. S. Chua, Benjámin Kováts, B. Englinger, B. Balakrishnan, Bin Gong, B. Agianian, Brandon Pressly, Brenda P. Medellin Salas, Brendan M Duggan, B. Geisbrecht, B. Dymock, B. Morten, Bruce D. Hammock, B. E. Mota, Bryan C. Dickinson, Cameron Fraser, Camille Lempicki, C. Novina, C. Torner, C. Ballatore, Carlotta Bon, Carly J. Chapman, C. Partch, Catherine T. Chaton, Chang Huang, Chao-Yie Yang, Charlene M. Kahler, Charles Karan, Charles Keller, C. Dieck, Huimei Chen, Chen Liu, C. Peltier, C. Mantri, Chinyere Kemet, Christa E. Müller, Christian Weber, Christina M. Zeina, Christine S. Muli, C. Morisseau, Cigdem Alkan, Clara Reglero, Cody A. Loy, Cornelia M. Wilson, Courtney B. Myhr, Cristina Arrigoni, Cristina Paulino, César Santiago, Dahai Luo, D. Tumes, D. Keedy, Daniel A. Lawrence, Daniel Chen, Danny Manor, Darci J. Trader, David A Hildeman, David H. Drewry, David J. Dowling, D. Hosfield, David M. Smith, David Moreira, D. Siderovski, David Shum, David T. Krist, D. W. Riches, D. Ferraris, Deborah H. Anderson, D. R. Coombe, D. Welsbie, D. Hu, Diana Ortiz, Dina Alramadhani, Dingqiang Zhang, Dipayan Chaudhuri, Dirk Jan Slotboom, D. Ronning, Donghan Lee, Dorian Dirksen, Douglas A. Shoue, D. Zochodne, D. Krishnamurthy, Dustin Duncan, Dylan M Glubb, E. Gelardi, Edward C. Hsiao, E. Lynn, Elany Barbosa da Silva, Elena Aguilera, E. Lenci, Elena Abraham, Eleonora Lama, Eleonora Mameli, Elisa Leung, Emily M. Christensen, Emily R. Mason, Enrico Petretto, Ephraim F. Trakhtenberg, Eric J. Rubin, Erick Strauss, Erik W. Thompson, E. Cione, E. Lisabeth, Erkang Fan, E. Kroon, Eunji Jo, E. García-Cuesta, E. Glukhov, E. Gavathiotis, Fang Yu, Fei Xiang, Fenfei Leng, Feng Wang, Filippo Ingoglia, F. van den Akker, Francesco Borriello, F. Vizeacoumar, F. Luh, Frederick S. Buckner, F. Vizeacoumar, F. B. Bdira, Fredrik Svensson, G. M. Rodriguez, Gabriella Bognár, Gaia Lembo, Gang Zhang, Garret E Dempsey, Gary Eitzen, G. Mayer, Geoffrey L. Greene, George A. Garcia, G. Lukács, Gergely Prikler, G. C. G. Parico, G. Colotti, Gilles De Keulenaer, G. Cortopassi, G. Roti, Giulia Girolimetti, G. Fiermonte, G. Gasparre, G. Leuzzi, Gopal Dahal, G. Michlewski, G. Conn, Grant David Stuchbury, Gregory R. Bowman, G. Popowicz, G. Veit, G. D. de Souza, Gustav Akk, G. Caljon, Guzmán Alvarez, Gwennan Rucinski, Gyeongeun Lee, Gökhan Cildir, Hai Li, Hairol E. Breton, Hamed Jafar-Nejad, Han Zhou, Hannah P. Moore, Hannah Tilford, Haynes Yuan, Heesung Shim, Heike Wulff, Heinrich Hoppe, Helena Chaytow, Heng-Keat Tam, Holly Van Remmen, Hongyang Xu, H. Debonsi, Howard B. Lieberman, Hoyoung Jung, Hua-Ying Fan, Hui Feng, Hui Zhou, H. Kim, I. Greig, Ileana Caliandro, Ileana Corvo, I. Arozarena, Imran N. Mungrue, I. Verhamme, I. Qureshi, Irina Lotsaris, Isin Cakir, J. Perry, Jacek Kwiatkowski, J. Boorman, Jacob Ferreira, Jacob Fries, J. Kratz, Jaden Miner, Jair L. Siqueira-Neto, James G. Granneman, James Ng, J. Shorter, J. Voss, J. Gebauer, Janelle Chuah, J. Mousa, Jason T. Maynes, Jay D. Evans, J. Dickhout, J. MacKeigan, J. Jossart, Jia Zhou, Jiabei Lin, Jiake Xu, Jianghai Wang, Jiaqi Zhu, Jiayu Liao, Jingyi Xu, Jinshi Zhao, Jiusheng Lin, Jiyoun Lee, J. Reis, J. Stetefeld, J. B. Bruning, J. B. Bruning, John G. Coles, John J. Tanner, John M. Pascal, Jonathan So, J. L. Pederick, J. Costoya, Joseph B. Rayman, J. J. Maciag, J. Nasburg, Joshua J Gruber, Joshua M. Finkelstein, Joshua Watkins, J. Rodríguez-Frade, Juan Antonio Sanchez Arias, J. Lasarte, J. Oyarzábal, Julian Milosavljevic, J. Cools, Julien Lescar, Julijus Bogomolovas, Jun Wang, Jung-Min Kee, Junzhuo Liao, Jyothi C. Sistla, J. Abrahão, Kamakshi L Sishtla, Karol R. Francisco, Kasper B. Hansen, Kathleen A. Molyneaux, Kathryn A Cunningham, Katie R. Martin, K. Gadar, K. Ojo, Keith S. Wong, K. Wentworth, Kent Lai, K. Lobb, K. M. Hopkins, K. Parang, K. Machaca, Kien Pham, Kim Ghilarducci, K. Sugamori, K. J. McManus, Kirsikka Musta, K. Faller, Kiyonobu Nagamori, Konrad J Mostert, Konstantin V. Korotkov, Koting Liu, Kristiana S. Smith, K. Sarosiek, Kyle H. Rohde, Kyu Kwang Kim, Kyung Hyeon Lee, Lajos Pusztai, L. Lehtiö, Larisa M. Haupt, L. Cowen, Lee J. Byrne, Leila Su, León Wert-Lamas, L. Puchades-Carrasco, Lifeng Chen, L. Malkas, Ling Zhuo, Lizbeth Hedstrom, L. Walensky, Lorenzo Antonelli, L. Iommarini, Luke Whitesell, Lía M. Randall, M. Fathallah, M. H. Nagai, M. Kilkenny, Manu Ben-Johny, Marc P. Lussier, M. Windisch, Marco Lolicato, M. Lolli, M. Vleminckx, M. Caroleo, Maria J. Macias, M. Valli, Marim M. Barghash, M. Mellado, M. Tye, M. A. Wilson, Mark Hannink, Mark R. Ashton, M. V. C. Cerna, M. Giorgis, M. Safo, Martin St. Maurice, M. McDowell, M. Pasquali, Masfique Mehedi, M. Serafim, M. Soellner, M. Alteen, Matthew M. Champion, Maxim Skorodinsky, Megan L. O’Mara, Mel Bedi, Menico Rizzi, Michael Levin, Michael Mowat, Michael R. Jackson, M. Paige, Minnatallah Al-Yozbaki, M. Giardini, M. Maksimainen, Monica De Luise, Muhammad Saddam Hussain, M. Christodoulides, Natalia Stec, N. Zelinskaya, Natascha Van Pelt, Nathan M. Merrill, Nathanael I. Singh, N. Kootstra, Neeraj Singh, Neha S. Gandhi, Nei-Li Chan, Nguyen Mai Trinh, Nicholas O. Schneider, Nick Matovic, N. Horstmann, Nicola Longo, N. Bharambe, Nirvan Rouzbeh, N. Mahmoodi, N. Gumede, N. Anastasio, N. Khalaf, O. Rabal, Olga Kandror, Olivier Escaffre, O. Silvennoinen, Ozlem Tastan Bishop, Pablo Iglesias, P. Sobrado, Patrick Chuong, Patrick O’Connell, P. Martin-Malpartida, P. Mellor, P. Fish, P. O. L. Moreira +499 moresemanticscholar +1 more sourceNovel Prenylated Indole Alkaloids with Neuroprotection on SH-SY5Y Cells against Oxidative Stress Targeting Keap1–Nrf2
Marine Drugs, 2022 Oxidative stress has been implicated in the etiology of Parkinson’s disease (PD). Molecules non-covalently binding to the Keap1–Nrf2 complex could be a promising therapeutic approach for PD. Herein, two novel prenylated indole alkaloids asperpenazine (1),Xueyang Xiao, Zhou Tong, Yuexing Zhang, Hui Zhou, Mengying Luo, Tianhui Hu, Ping Hu, Luqi Kong, Zeqin Liu, Chan Yu, Zhiyong Huang, Linzhen Hu +11 moredoaj +1 more sourceDigital Barcodes for High-Throughput Screening
Chem & bio engineeringHigh-throughput screening is an indispensable technology in drug discovery, cancer therapy, and disease diagnosis, and it could greatly reduce time cost, reagent consumption, and labor expense.Ze Yang, Jingyi Chen, Yao Xiao, Chenjing Yang, Chunlan Zhao, Dong Chen, D. Weitz +6 moresemanticscholar +1 more sourceOrganoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.Carla Ríos Arceo, Jarno Drostwiley +1 more sourceSemiconductor Electronic Label-Free Assay for Predictive Toxicology. [PDF]
, 2016 While animal experimentations have spearheaded numerous breakthroughs in biomedicine, they also have spawned many logistical concerns in providing toxicity screening for copious new materials. Their prioritization is premised on performing cellular-level Chui, Chi On, Ji, Zhaoxia, Mao, Yufei, Meng, Huan, Shin, Kyeong-Sik, Wang, Xiang +5 morecore +2 more sources
