Results 51 to 60 of about 485,334 (314)

A Searchable Database of Crystallization Cocktails in the PDB: Analyzing the Chemical Condition Space

Patterns, 2020
Summary: Nearly 90% of structural models in the Protein Data Bank (PDB), the central resource worldwide for three-dimensional structural information, are currently derived from macromolecular crystallography (MX).
Miranda L. Lynch, Max F. Dudek, Sarah E.J. Bowman   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Breaking shackles of molecular weight and emission for NIR-II fluorophores by regulating Columb attraction interaction

Nature Communications
The second near-infrared (NIR-II) dyes provide advantages for in vivo imaging, but challenges persist. A primary issue is the lack of practicable strategies to balance emission wavelength and molecular weight, particularly for low-molecular-weight ( 1000 
Miantai Ye, Xiaoyu Wang, Jingwen Zou, Wei Sun, Weijie Chi, Zhiqiang Mao, Zhihong Liu   +6 more
doaj   +1 more source

The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma

Medicina, 2022
Background and Objectives: Activation of NRF2, a key transcription factor of cytoprotectant against oxidative stress, and its target genes are associated with aggressive tumor progression, metastasis and poor survival.
Duurenjargal Tseeleesuren, Hui-Hua Hsiao, Rajni Kant, Yu-Chuen Huang, Hung-Pin Tu, Chih-Chung Lai, Shiu-Feng Huang, Chia-Hung Yen   +7 more
doaj   +1 more source

Design automation of microfluidic droplet sorting platforms [PDF]

, 2019
Both basic research and biological design require high throughput screening to parse through the massive amounts of variants generated in experiments. However, the cost and expertise needed for use of such technology limit accessibility.
Densmore, Douglas, McIntyre, David
core  

High-throughput in vivo vertebrate screening [PDF]

, 2010
We demonstrate a high-throughput platform for cellular-resolution in vivo chemical and genetic screens on zebrafish larvae. The system automatically loads zebrafish from reservoirs or multiwell plates, and positions and rotates them for high-speed ...
A Funfak, AL Rubinstein, Bryan Kyo Koo, C Fricke, Carlos Pardo-Martin, CB Rohde, CE Buckley, Cody L Gilleland, DH Bhatt, GJ Lieschke, J Gehrig, J Karlsson, JD Steinmeyer, JT Shin, LI Zon, Mehmet Fatih Yanik, MF Yanik, P McGrath, Steven C Wasserman, T Xiao, Tsung-Yao Chang   +20 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Effects of novel microecologics combined with traditional Chinese medicine and probiotics on growth performance and health of broilers

Poultry Science, 2022
: In this study, we prepared a kind of novel microecologics, namely Chinese medicine–probiotic compound microecological preparation (CPCMP), which is composed of 5 traditional Chinese medicine herbs (Galla Chinensis, Andrographis paniculata, Arctii ...
Jin Gao, Rui Wang, Jingxuan Liu, Wenling Wang, Yong Chen, Wentao Cai   +5 more
doaj   +1 more source

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε [PDF]

, 2012
IKKε and TBK1 are noncanonical IKK family members which regulate inflammatory signaling pathways and also play important roles in oncogenesis. However, few inhibitors of these kinases have been identified.
Baldwin, Albert S., Cantley, Lewis C., Cheely, Adam W., Hutti, Jessica E., Janzen, William P., Kireev, Dmitri, Porter, Melissa A., Wang, Xiaodong   +7 more
core   +4 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source