Results 151 to 160 of about 231,965 (320)

From emulsion to single-phase microfluidics : an integrated approach to culture and perfusion of multicellular spheroids [PDF]

, 2016
This study presents a novel microfluidic approach for developing large scale screening assays of anticancer compounds on 3D multicellular spheroids.
Boyd, Marie, McMillan, Kay S, Zagnoni, Michele   +2 more
core  

Supraparticles Composed of Graphitic Carbon Nitride Nanoparticles and Silica‐Supported Horseradish Peroxidase as Customizable Hybrid Catalysts for Photo‐Biocatalytic Cascade Reactions in Continuous Flow

Advanced Functional Materials, EarlyView.
Herein presented supraparticles combine the nanoparticulate photocatalyst graphitic carbon nitride with the enzyme horseradish peroxidase, which is immobilized on silica nanoparticles. In an optimized compatibility range, both catalysts operate effectively within the hybrid supraparticles and catalyze a cascade reaction consisting of the photocatalytic
Bettina Herbig, Egzon Cermjani, Doris Hanselmann, Johannes Prieschl, Angelika Schmitt, Michael S. Moritz, Christian Papp, Greta Nölke, Stefano Di Fiore, Christoph Deckers, Thomas H. Rehm, Susanne Wintzheimer   +11 more
wiley   +1 more source

High-Throughput Fluorescence-Based Screening Assays for Tryptophan-Catabolizing Enzymes [PDF]

, 2014
Nicole Seegers, Antoon M. van Doornmalen, Joost C.M. Uitdehaag, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman   +5 more
openalex   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. [PDF]

Sci Rep, 2020
Su L, Bryan N, Battista S, Freitas J, Garabedian A, D'Alessio F, Romano M, Falanga F, Fusco A, Kos L, Chambers J, Fernandez-Lima F, Chapagain PP, Vasile S, Smith L, Leng F.   +15 more
europepmc   +1 more source

A K_V2.1 gating modifier binding assay suitable for high throughput screening [PDF]

, 2009
William A. Schmalhofer, Kevin S. Ratliff, Adam B. Weinglass, Gregory J. Kaczorowski, María L. García, James Herrington   +5 more
openalex   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

591: A novel high-throughput screening assay for PTC readthrough modulators relies on the native CFTR gene: Profiling of known compounds

, 2021
Feng Liang, Nikole J. Jordan, Huiwen Shang, S. Cantu, L. Wang, Adam C. Bell, H. Valley, Yu‐Sheng Cheng, K. Coote, Hermann Bihler, Martin Mense   +10 more
openalex   +1 more source

Label-Free High-Throughput Screening Assay for the Identification of Norepinephrine Transporter (NET / SLC6A2) Inhibitors [PDF]

, 2021
Hubert J. Sijben, Wieke van Oostveen, Peter B. R. Hartog, Laura Stucchi, Giovanna Maresca, Lia Scarabottolo, Adriaan P. IJzerman, Laura H. Heitman   +7 more
openalex   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source