Results 251 to 260 of about 16,128,167 (280)

High-throughput screening assays for the identification of chemical probes

Nature Chemical Biology, 2007
High-throughput screening (HTS) assays enable the testing of large numbers of chemical substances for activity in diverse areas of biology. The biological responses measured in HTS assays span isolated biochemical systems containing purified receptors or enzymes to signal transduction pathways and complex networks functioning in cellular environments ...
James, Inglese, Ronald L, Johnson, Anton, Simeonov, Menghang, Xia, Wei, Zheng, Christopher P, Austin, Douglas S, Auld   +6 more
openaire   +2 more sources

Phosphatase High-Throughput Screening Assay Design and Selection

2013
Phosphatases are a heterogeneous group of enzymes catalyzing dephosphorylation of diverse substrates ranging from small organic molecules to large phosphorylated multiprotein complexes. A wide variety of biochemical approaches for measuring phosphatase activity exists.
openaire   +2 more sources

Microplate assays for high-throughput screening.

Current opinion in drug discovery & development, 2009
Microplates containing an 8 x 12 array of 96-wells are the most prevalent format for screening compound libraries in high-throughput applications today. These plates are suitable for use in a wide variety of homogeneous and heterogeneous assays to measure binding interactions, enzyme activity and cell proliferation.
openaire   +1 more source

A high throughput screening assay for human Thyroperoxidase inhibitors

Toxicology in Vitro
Rapid, human relevant assays are needed to assess potential hazards of the many chemicals in commerce. An assay of thyroid peroxidase (TPO) inhibition, using the substrate Amplex Ultra Red, was recently adapted for human TPO (AUR-hTPO). We tested a large number (788) of chemicals through this AUR-hTPO assay and compared performance with published ...
Hongyan, Dong, Katie Paul, Friedman, Alain, Filiatreault, Errol M, Thomson, Michael G, Wade   +4 more
openaire   +2 more sources

High-Throughput Screening Assays

2017
openaire   +2 more sources

High-Throughput Screening Assays in Toxicology

2022
openaire   +1 more source

Alternative statistical parameter for high-throughput screening assay quality assessment.

Journal of Biomolecular Screening, 2007
Zhijin Wu
exaly  

Considerations for the design and reporting of enzyme assays in high-throughput screening applications

Perspectives in Science, 2014
Michael G Acker, Douglas S Auld
exaly  

Cancer screening in the United States, 2019: A review of current American Cancer Society guidelines and current issues in cancer screening

Ca-A Cancer Journal for Clinicians, 2019
Stacey A Fedewa, Richard C Wender, Robert A Smith   +2 more
exaly  

Assay concordance between SPA and TR-FRET in high-throughput screening.

Journal of Biomolecular Screening, 2006
Anne Schmidt
exaly