Results 241 to 250 of about 137,634 (294)

Functional drug screening of tumor organoids on an active-matrix digital microfluidic chip for cancer precision medicine. [PDF]

Microsyst Nanoeng
Sun R, Feng Z, Wu T, Ding F, Wu Y, Jin K, Li L, Jia Z, Gao R, Cong Y, Ho TY, Ma H, Hu S, Zhang L, Dong W.   +14 more
europepmc   +1 more source

High-throughput screening to engineer optimal T cell therapies: current knowledge and future prospects. [PDF]

Front Oncol
Liu L, Chen S, Ding M, Duan Y, Pu L, Li L, Peng H, Yu Q.   +7 more
europepmc   +1 more source

Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics.

Lab Chip
Naquin T, Naquin C, Wu Q, Chen Y, Canning A, Yang K, Li Y, Zhao S, Ling Y, Ma Z, Jin K, He Y, Yang S, Lee LP, Huang TJ.   +14 more
europepmc   +1 more source

Enzyme assays for high-throughput screening

Current Opinion in Biotechnology, 2004
Assaying enzyme-catalyzed transformations in high-throughput is crucial to enzyme discovery, enzyme engineering and the drug discovery process. In enzyme assays, catalytic activity is detected using labelled substrates or indirect sensor systems that produce a detectable spectroscopic signal upon reaction.
Jean-Philippe, Goddard, Jean-Louis, Reymond   +1 more
core   +5 more sources

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Cell-Based Assays for High-Throughput Screening

Molecular Biotechnology, 2010
Cell-based assays represent approximately half of all high-throughput screens currently performed. Here, we review in brief the history and status of high-throughput screening (HTS), and summarize some of the challenges and benefits associated with the use of cell-based assays in HTS.
W Frank An, Nicola Tolliday, Tolliday Nicola   +2 more
exaly   +3 more sources

Complex phenotypic assays in high-throughput screening

Current Opinion in Chemical Biology, 2004
High-throughput screening (HTS), systematically testing thousands of small molecules to find candidates for lead optimization, primarily involves exposure of purified proteins to arrayed collections of small molecules. More complex phenotypic assays, such as cell-based or whole-organism assays, traditionally have flanked HTS, preceding it to validate ...
Paul A Clemons
exaly   +3 more sources

Scintillation Proximity Assays in High-Throughput Screening

ASSAY and Drug Development Technologies, 2008
Scintillation proximity assays (SPAs) have become a powerful tool for high-throughput screening (HTS) because they can measure the activity and binding of very diverse classes of drug targets. By applying the basic principles of ligand-receptor binding and enzyme kinetics, it is possible to build a large variety of miniaturized, high-throughput assays ...
J Fraser, Glickman, Andres, Schmid, Sandrine, Ferrand   +2 more
openaire   +3 more sources

Acetylcholinesterase Inhibition Assays for High-Throughput Screening

2022
Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh), a vital neurotransmitter that regulates muscle movement and brain function, including memory, attention, and learning. Inhibition of AChE activity can cause a variety of adverse health effects and toxicity. Identifying AChE inhibitors quickly and efficiently warrants developing AChE inhibition
Shuaizhang, Li, Andrew J, Li, Jinghua, Zhao, Michael F, Santillo, Menghang, Xia   +4 more
openaire   +2 more sources