Results 221 to 230 of about 16,128,167 (280)

Zebrafish swimming towards cures: a scalable NAM platform for drug discovery. [PDF]

Drug Discov Today
Cutinho V, Williams CH.
europepmc   +1 more source

From empirical imprinting to programmable synthetic receptors: a perspective on data science and machine learning for molecularly imprinted polymers.

Polym Chem
Alsholi A, Tiwari S, Zhang J, Peeters M.
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

High-throughput screening: advances in assay technologies

Current Opinion in Chemical Biology, 1997
Both isotopic and nonisotopic assay methodologies are employed in high-throughput screening for drug discovery. Recent advances in cell-based and in vitro biochemical assays will be reviewed, with special emphasis on detection technologies amenable to automated 'mix and read' procedures in high-throughput screening.
William P Janzen, Steven D Kahl, G Sitta Sittampalam   +2 more
exaly   +3 more sources

Enzyme assays for high-throughput screening

Current Opinion in Biotechnology, 2004
Assaying enzyme-catalyzed transformations in high-throughput is crucial to enzyme discovery, enzyme engineering and the drug discovery process. In enzyme assays, catalytic activity is detected using labelled substrates or indirect sensor systems that produce a detectable spectroscopic signal upon reaction.
Goddard JP, Reymond JL
openaire   +4 more sources

Cell-Based Assays for High-Throughput Screening

Molecular Biotechnology, 2010
Cell-based assays represent approximately half of all high-throughput screens currently performed. Here, we review in brief the history and status of high-throughput screening (HTS), and summarize some of the challenges and benefits associated with the use of cell-based assays in HTS.
W Frank An
exaly   +3 more sources

New assay technologies for high-throughput screening

Current Opinion in Chemical Biology, 1998
The use of high-throughput screening for early stage drug discovery imposes several constraints on the format of assays for therapeutic targets of interest. Homogeneous cell-free assays based on energy transfer, fluorescence polarization spectroscopy or fluorescence correlation spectroscopy provide the sensitivity, ease, speed and resistance to ...
Robert E. Campbell, James Broach
exaly   +3 more sources

Scintillation Proximity Assays in High-Throughput Screening

ASSAY and Drug Development Technologies, 2008
Scintillation proximity assays (SPAs) have become a powerful tool for high-throughput screening (HTS) because they can measure the activity and binding of very diverse classes of drug targets. By applying the basic principles of ligand-receptor binding and enzyme kinetics, it is possible to build a large variety of miniaturized, high-throughput assays ...
J Fraser, Glickman, Andres, Schmid, Sandrine, Ferrand   +2 more
openaire   +3 more sources