Results 61 to 70 of about 1,074,205 (395)

Transcriptome-Wide High-Throughput m6A Sequencing of Differential m6A Methylation Patterns in the Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Cell Line MH7A

open access: yesJournal of Inflammation Research, 2021
Hui Jiang1,2 *,* Kefeng Cao3 *,* Chang Fan,1,2 Xiaoya Cui,1,2 Yanzhen Ma,1,2 Jian Liu1 1Experimental Center of Clinical Research, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, People’s Republic of China; 2School ...
Jiang H   +5 more
doaj  

Probing the connectivity of neural circuits at single-neuron resolution using high-throughput DNA sequencing [PDF]

open access: yes, 2011
There is growing excitement in determining the complete connectivity diagram of the brain—the "connectome". So far, the complete connectome has been established for only one organism, C.
Alex Koulakov   +6 more
core   +2 more sources

Universal count correction for high-throughput sequencing.

open access: yesPLoS Computational Biology, 2014
We show that existing RNA-seq, DNase-seq, and ChIP-seq data exhibit overdispersed per-base read count distributions that are not matched to existing computational method assumptions.
Tatsunori B Hashimoto   +2 more
doaj   +1 more source

ReSeq simulates realistic Illumina high-throughput sequencing data

open access: yesGenome Biology, 2021
In high-throughput sequencing data, performance comparisons between computational tools are essential for making informed decisions at each step of a project.
Stephan Schmeing, Mark D. Robinson
doaj   +1 more source

Scrutinizing virus genome termini by high-throughput sequencing. [PDF]

open access: yesPLoS ONE, 2014
Analysis of genomic terminal sequences has been a major step in studies on viral DNA replication and packaging mechanisms. However, traditional methods to study genome termini are challenging due to the time-consuming protocols and their inefficiency ...
Shasha Li   +6 more
doaj   +1 more source

Deep Sequencing Analysis of RNAs from Citrus Plants Grown in a Citrus Sudden Death-Affected Area Reveals Diverse Known and Putative Novel Viruses. [PDF]

open access: yes, 2017
Citrus sudden death (CSD) has caused the death of approximately four million orange trees in a very important citrus region in Brazil. Although its etiology is still not completely clear, symptoms and distribution of affected plants indicate a viral ...
Coletta-Filho, Helvecio D   +7 more
core   +3 more sources

High-throughput sequencing: a failure mode analysis

open access: yesBMC Genomics, 2005
Background Basic manufacturing principles are becoming increasingly important in high-throughput sequencing facilities where there is a constant drive to increase quality, increase efficiency, and decrease operating costs.
Marra Marco A   +6 more
doaj   +1 more source

Efficient COI barcoding using high throughput single-end 400 bp sequencing

open access: yesBMC Genomics, 2020
Background Over the last decade, the rapid development of high-throughput sequencing platforms has accelerated species description and assisted morphological classification through DNA barcoding. However, the current high-throughput DNA barcoding methods
Chentao Yang   +14 more
doaj   +1 more source

LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets

open access: yesNucleic Acids Research, 2012
The study of cell-population heterogeneity in a range of biological systems, from viruses to bacterial isolates to tumor samples, has been transformed by recent advances in sequencing throughput. While the high-coverage afforded can be used, in principle,
A. Wilm   +9 more
semanticscholar   +1 more source

High-throughput sequencing reveals a simple model of nucleosome energetics

open access: yes, 2010
We use nucleosome maps obtained by high-throughput sequencing to study sequence specificity of intrinsic histone-DNA interactions. In contrast with previous approaches, we employ an analogy between a classical one-dimensional fluid of finite-size ...
A. V. Morozov   +26 more
core   +1 more source

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