Results 81 to 90 of about 1,036,014 (384)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

AlmostSignificant:simplifying quality control of high-throughput sequencing data [PDF]

, 2016
Motivation: The current generation of DNA sequencing technologies produce a large amount of data quickly. All of these data need to pass some form of quality control (QC) processing and checking before they can be used for any analysis.
Christian Cole, Geoffrey J. Barton, Joseph Ward, Melanie Febrer, Ramirez-Gonzalez   +4 more
core   +5 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

High-Throughput Sequencing Survey of Sunflower Soil

Microbiology Resource Announcements, 2021
Plant rhizobiomes are responsible for major soil processes in the immediate plant environment, but our knowledge of the linkage between below-ground microbiota diversity and plant health is limited. We studied the bacterial and archaeal communities of sunflower rhizosphere organisms by comparing the composition of these communities in bulk soil at ...
Olubukola Oluranti Babalola, Blessing Chidinma Nwachukwu, Ayansina Segun Ayangbenro   +2 more
openaire   +3 more sources

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing

Nucleic Acids Research, 2016
Allele-specific copy number analysis (ASCN) from next generation sequencing (NGS) data can greatly extend the utility of NGS beyond the identification of mutations to precisely annotate the genome for the detection of homozygous/heterozygous deletions ...
R. Shen, V. Seshan
semanticscholar   +1 more source

rMAPS: RNA map analysis and plotting server for alternative exon regulation. [PDF]

, 2016
RNA-binding proteins (RBPs) play a critical role in the regulation of alternative splicing (AS), a prevalent mechanism for generating transcriptomic and proteomic diversity in eukaryotic cells.
Jung, Sungbo, Park, Juw Won, Rouchka, Eric C, Tseng, Yu-Ting, Xing, Yi   +4 more
core   +2 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Transkingdom Networks: A Systems Biology Approach to Identify Causal Members of Host-Microbiota Interactions

, 2017
Improvements in sequencing technologies and reduced experimental costs have resulted in a vast number of studies generating high-throughput data. Although the number of methods to analyze these "omics" data has also increased, computational complexity ...
A Fuente de la, A Morgun, A Morgun, A Mortazavi, A Perez-Diez, A Yambartsev, AR Erickson, AR Joyce, B Buchfink, B Langmead, BJ Haas, C Trapnell, CL Poirel, CL Schoch, DH Huson, DJ Lane, DJ McCarthy, E Saccenti, E Stackebrandt, ER Mardis, F Imhann, F Meyer, Gautier, J Kuczynski, J Skinner, JG Caporaso, JL Brookman, JN Paulson, KL Mine, LD Thomas, M Martin, M Schirmer, MA Moreno-Risueno, ML Metzker, N Gehlenborg, N Krumm, N Segata, N Shulzhenko, O Morozova, P Li, PD Schloss, PW Laird, R Greer, R Schmieder, Ritchie, RL Greer, RR Rodrigues, S Anders, S Goodwin, S Lindgreen, S Weiss, S Zhao, SC Schuster, TJ Sharpton, W Zhang, X Dong, YJ Hua   +56 more
core   +1 more source