Results 61 to 70 of about 15,584,188 (261)

An evaluation of genotyping by sequencing (GBS) to map the Breviaristatum-e (ari-e) locus in cultivated barley [PDF]

, 2014
We explored the use of genotyping by sequencing (GBS) on a recombinant inbred line population (GPMx) derived from a cross between the two-rowed barley cultivar 'Golden Promise' (ari-e.GP/Vrs1) and the six-rowed cultivar 'Morex' (Ari-e/vrs1) to map plant ...
Arnis Druka, Jesse Poland, Micha Bayer, Robbie Waugh, Bayer, Micha, Pete E Hedley, Hui Liu, Druka, Arnis, Hackett, Christine A., Luke Ramsay, Ramsay, Luke, Poland, Jesse, Christine A Hackett, Liu, Hui, Hedley, Pete E., Waugh, Robbie; id_orcid, Russell, Joanne R., Joanne R Russell   +17 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

High-throughput sequencing raw data

, 2018
High-throughput sequencing raw data for 3 samples（Read1）, A1;A2;A3 are three samples from control ...
Manxin Fang (5768321)
core   +1 more source

Second-generation environmental sequencing unmasks marine metazoan biodiversity [PDF]

, 2010
Biodiversity is of crucial importance for ecosystem functioning, sustainability and resilience, but the magnitude and organization of marine diversity at a range of spatial and taxonomic scales are undefined.
Lambshead, P. John D., Sung, Way, Harriet F. Johnson, Sung, W., Blaxter, M. L., Way Sung, Power, Deborah M., Thomas, W. K., W. Kelley Thomas, Lambshead, P John D, Margaret Packer, Blaxter, Mark L., Fonseca, Vera G., Packer, Margaret, Power, Deborah, Thomas, W Kelley, Carvalho, Gary, Mark L. Blaxter, Creer, Simon, Simon P. Neill, Johnson, Harriet F, Simon Creer, Fonseca, V. G., Thomas, W. Kelley, Blaxter, Mark L, Deborah M. Power, Neill, Simon P, Creer, S., Carvalho, Gary R, Johnson, Harriet F., P. John D. Lambshead, Lambshead, P. J. D., Vera G. Fonseca, Gary R. Carvalho, Carvalho, Gary R., Fonseca, Vera G, Neill, Simon P., Power, Deborah M   +37 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]

, 2015
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Barroso, Vanessa, Drewry, David H., Kessler, Albane, Pilar Manzano, M., Cotillo, Ignacio, Roquero, Irene, Alonso-Padilla, Julio, Bardera, Ana I., Navarro, Miguel, Manzano, Pilar, Brown, James R., Sherstnev, Alexander, Alvarez, Emilio, Rodríguez López, Ana, Fiandor, Jose M., Julio Martin, J., Dios-Antón, Francisco de, Kumar, Vinod, Peña, Imanol, Martin, José Julio, Gray, David W., Gray, David W.; id_orcid, Rodriguez, Ana, Navarro, M., Cantizani, Juan, de Dios-Anton, Francisco, Colmenarejo, Gonzalo   +26 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Computational analysis of next generation sequencing data : from transcription start sites in bacteria to human non-coding RNAS [PDF]

, 2014
The advent of next generation sequencing (NGS) technologies has revolutionized the field of molecular biology by providing a wealth of sequence data. “Transcriptomics”, which aims to identify and annotate the complete set of RNA molecules transcribed ...
Jorjani, Hadi
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source