Results 91 to 100 of about 182,191 (313)

Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway

Frontiers in Pharmacology
BackgroundHypoxia-induced pulmonary vascular remodeling is central to the development of high-altitude pulmonary hypertension (HAPH). Rhodiola tangutica has traditionally been used to prevent chronic mountain sickness. Although its active fraction (ACRT)
Na Yang, Meiduo Huayu, Shanshan Su, Bin Hou, Zhanting Yang, Xingmei Nan, Zhanqiang Li, Zhanqiang Li   +7 more
doaj   +1 more source

Whole Atmosphere Simulation of Anthropogenic Climate Change

Geophysical Research Letters, 2018
We simulated anthropogenic global change through the entire atmosphere, including the thermosphere and ionosphere, using the Whole Atmosphere Community Climate Model‐eXtended.
Stanley C. Solomon, Han‐Li Liu, Daniel R. Marsh, Joseph M. McInerney, Liying Qian, Francis M. Vitt   +5 more
doaj   +1 more source

Medical And Physiological Considerations For A High-Altitude Mma Site

, 1996
1. Introduction 2. Medical and Physiological Effects of High Altitude 2.1 Normal Response to Hypoxia 2.2 Acclimatization 2.3 Sleep 2.4 Exercise 2.5 Mental Ability 2.6 Acute Mountain Sickness (AMS) 2.7 High Altitude Pulmonary Edema (HAPE) 2.8 High ...
P.J. Napier, A High-altitude, Mma Site, J.B. West   +3 more
core  

Incidence of High Altitude Illnesses among Unacclimatized Persons Who Acutely Ascended to Tibet

, 2010
Ren, Yusheng, Zhongming Fu, Weimin Shen, Ping Jiang, Yanlin He, Shaojun Peng, Zonggui Wu, and Bo Cui. Incidence of high altitude illnesses among unacclimatized persons who acutely ascended to Tibet. High Alt. Med. Biol.
Zhongming Fu, Ping Jiang, Jiang, Ping, Bo Cui, He, Yanlin, Wu, Zonggui, Ren, Yusheng, Peng, Shaojun, Zonggui Wu, Weimin Shen, Yusheng Ren, Shen, Weimin, Shaojun Peng, Cui, Bo, Fu, Zhongming, Yanlin He   +15 more
core   +1 more source

High‐Speed Altitude Regulation With Neuromorphic Camera and Lightweight Embedded Computation

Advanced Intelligent Systems, EarlyView.
Neuromorphic cameras deliver rapid, high‐dynamic‐range sensing but overwhelm embedded processors at high speeds. This work presents a lightweight, optimized Lucas–Kanade optical flow method with parallelization, gyroscopic derotation, and adaptive event slicing.
Simon L. Jeger, Alessandro Marchei, Charbel Toumieh, Dario Floreano   +3 more
wiley   +1 more source

Arachidonic Acid Metabolism Pathway Is Not Only Dominant in Metabolic Modulation but Associated With Phenotypic Variation After Acute Hypoxia Exposure

Frontiers in Physiology, 2018
Background: The modulation of arachidonic acid (AA) metabolism pathway is identified in metabolic alterations after hypoxia exposure, but its biological function is controversial.
Chang Liu, Chang Liu, Chang Liu, Bao Liu, Bao Liu, Bao Liu, Bao Liu, Lu Liu, Lu Liu, Lu Liu, Er-Long Zhang, Er-Long Zhang, Er-Long Zhang, Bind-da Sun, Bind-da Sun, Bind-da Sun, Gang Xu, Gang Xu, Gang Xu, Jian Chen, Jian Chen, Jian Chen, Yu-qi Gao, Yu-qi Gao, Yu-qi Gao   +24 more
doaj   +1 more source

Middle Ear Function and Pathophysiology in Andean Children Living at High Altitudes

, 2017
The extent of altitude-related middle ear disorders in children native to high altitudes is unclear. This study examined middle ear pathophysiology in two groups of children living in high-altitude Ecuadorian Andean communities by investigating middle ...
Laurell, Göran,, Ortega, Fernando,, Buchanan, Leo H.,, S. Allen Counter, Göran Laurell, Leo H. Buchanan, Counter, S. Allen,, Fernando Ortega, Anthony B. Jacobs, Jacobs, Anthony B.,   +9 more
core   +1 more source

The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives [PDF]

, 2019
In contrast to Andean natives, high altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity.
Dawkins, Tony G., Levine, Benjamin D., Shave, Rob, Gasho, Christopher, Villafuerte, Francisco C., Ainslie, Philip N., Dawkins, Tony, Drane, Aimee, Stembridge, Mike, Williams, Alexandra M., Drane, Aimee L.   +10 more
core   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Neocytolysis of red blood cells following high altitude exposure

, 2011
Introduction: The cellular changes, driven by hypoxia exposure, represent an adequate response to the high altitude environment making newly generated RBCs more fit to manage oxygen uptake and delivery.Objective: to answer following questions: 1) Do the ...
RISSO, Angela, ANTONUTTO, Guglielmo
core   +1 more source