Results 91 to 100 of about 17,221,339 (259)

Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination [PDF]

, 2014
We thank the UK EPSRC for funding, the CR-UK/EPSRC/MRC/DoH (England) imaging programme, the European Union project FAMOS (FP7 ICT, contract no. 317744) and the European Union project IIIOS (FP7/2007-2013, contract no. 238802).
C. Simon Herrington, Bavishna B. Praveen, Herrington, C.S., Andrew Riches, Bellini, N., Ashok, P.C., Praveen, B.B., Nicola Bellini, Riches, A., Dholakia, K., Praveen C. Ashok, Kishan Dholakia   +11 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Microwave-Assisted Synthesis and Characterization of Iron Oxide Nanoparticles for Advanced Biomedical Sensing Applications

IEEE Open Journal of Nanotechnology
This study focuses on the synthesis and characterization of Superparamagnetic Iron Oxide Nanoparticles (IONPs) with potential biomedical and sensing applications.
Vivek Pratap Singh, Chandra Prakash Singh, Santosh Kumar, Saurabh Kumar Pandey, Deepak Punetha   +4 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Contrast agents and renal cell apoptosis [PDF]

, 2008
Contrast media (CM) induce a direct toxic effect on renal tubular cells. This toxic effect may have a role in the pathophysiology of contrast nephropathy.
Romano, Giulia
core   +1 more source

Structural rearrangements of membrane proteins probed by water-edited solid-state NMR spectroscopy [PDF]

, 2009
We show that water-edited solid-state NMR spectroscopy allows for probing global protein conformation and residue-specific solvent accessibility in a lipid bilayer environment.
Ader, C., NMR Spectroscopy, Baldus, M., Seidel, K., Schneider, R., Etzkorn, M., Becker, S., Sub NMR Spectroscopy, Dep Scheikunde   +8 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Biophotonics Modalities for High-Resolution Imaging of Microcirculatory Tissue Beds Using Endogenous Contrast: A Review on Present Scenario and Prospects

International Journal of Optics, 2011
The microcirculation is a complex system, and the visualization of microcirculation has great significance in improving our understanding of pathophysiological processes in various disease conditions, in both clinical and fundamental studies.
Hrebesh M. Subhash
doaj   +1 more source

Transmission Near-Infrared (NIR) and Photon Time-of-Flight (PTOF) Spectroscopy in a Comparative Analysis of Pharmaceuticals. [PDF]

, 2015
We present a comprehensive study of the application of photon time-of-flight spectroscopy (PTOFS) in the wavelength range 1050– 1350 nm as a spectroscopic technique for the evaluation of the chemical composition and structural properties of ...
Kamran, Faisal, Svensson, Olof, Abildgaard, Otto H. A.,, Johansson, Jonas, Sparen, Anders,, Andersen, Peter E.,, Andersen, Peter E., Kamran, Faisal,, Sparén, Anders, Khoptyar, Dmitry, Abildgaard, Otto H. A., Andersson-Engels, Stefan,, Abildgaard, Otto Højager Attermann, Johansson, Jonas,, Khoptyar, Dmitry,, Svensson, Olof,, Lund University., Andersson-Engels, Stefan   +17 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source