Results 71 to 80 of about 17,221,339 (259)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Sulfur-rich Atmosphere for the Young Jupiter Analog AF Lep b Reveals Significant Solid Accretion

The Astronomical Journal
AF Lep b is one of the closest analogs to Jupiter in terms of mass (3​​​​​​–4 M _Jup ) and semimajor axis (9 au) amenable to spectroscopic characterization.
Jerry W. Xuan, William O. Balmer, Yayaati Chachan, Jean-Baptiste Ruffio, Kazumasa Ohno, Robert J. De Rosa, Aneesh Baburaj, Eric L. Nielsen, Ruth Murray-Clay, Jonathan J. Fortney, Marshall D. Perrin, Jason J. Wang, Brendan P. Bowler, Alexander Madurowicz, Bruce A. Macintosh, Yapeng Zhang, Björn Benneke, Alexis Bidot, Geoffrey A. Blake, Kyle Franson, Carrie He, Julie Inglis, Heather A. Knutson, Dimitri Mawet, Laurent Pueyo, Emily Rickman, Aniket Sanghi, Nicole L. Wallack   +27 more
doaj   +1 more source

Non-invasive low-cost deep tissue blood flow measurement with integrated Diffuse Speckle Contrast Spectroscopy

Frontiers in Neuroergonomics
Diffuse Correlation Spectroscopy (DCS) is a widely used non-invasive measurement technique to quantitatively measure deep tissue blood flow. Conventional implementations of DCS use expensive single photon counters as detecting elements and optical probes
Arindam Biswas, Penaz Parveen Sultana Mohammad, Sadhu Moka, Arash Takshi, Ashwin B. Parthasarathy   +4 more
doaj   +1 more source

Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging

Nanomaterials, 2011
Several mesoporous silica nanoparticle (MSN) contrast agents have been synthesized using a co-condensation method to incorporate two different Gd3+ complexes at very high loadings (15.5–28.8 wt %).
Wenbin Lin, Joseph Della Rocca, Kathryn M. L. Taylor-Pashow   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Distinct Difference in Sensitivity of NIR vs. IR Bands of Melamine to Inter-Molecular Interactions with Impact on Analytical Spectroscopy Explained by Anharmonic Quantum Mechanical Study

Molecules, 2019
Melamine (IUPAC: 1,3,5-Triazine-2,4,6-triamine) attracts high attention in analytical vibrational spectroscopy due to its misuse as a food adulterant.
Justyna Grabska, Krzysztof B. Beć, Christian G. Kirchler, Yukihiro Ozaki, Christian W. Huck   +4 more
doaj   +1 more source

Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus indocyanine green injection and near-infrared spectroscopy [PDF]

, 2007
To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of indocyanine green (ICG) detected by near infrared spectroscopy in adult human heads, simulations were performed using a two layered model, representing the ...
Tachtsidis, I, Tachtsidis, I., Delpy, D., Tisdall, M, Leung, T., Smith, M., Elwell, CE, Elwell, C., Delpy, DT, Tisdall, M., Leung, TS, Smith, M   +11 more
core  

High-contrast pump-probe spectroscopy with high-order harmonics [PDF]

, 2008
The high order harmonic generation process from molecules can be used to probe the structure of the emitting medium with high spatial resolution [1, 2]. The measurements of molecular dynamics with such a probe is thus very appealing.
Sali\ue8res, P., P.B. Corkum, Breger, P., S. Haessler, Higuet, J., Fabre, B, Corkum, P., M\ue9vel, E., Corkum, P. B., P. Salières, Salières, P., Constant, E, Mairesse, Y., D. Descamps, W. Boutu, Descamps, D, Petit, S, S. Petit, Mével, E., E. Mével, Dudovich, N, E. Constant, P. B. Corkum, Dudovich, N., J. Higuet, D. M. Villeneuve, Haessler, Stefan, Mairesse, Y, Boutu, W., Constant, E., Villeneuve, D., Petit, S., B. Fabre, Fabre, B., Haessler, S., Villeneuve, D.M., Higuet, J, D.M. Villeneuve, Mével, E, Y. Mairesse, P. Breger, Salières, Pascal, Villeneuve, David, Boutu, W, Breger, P, N. Dudovich, Descamps, D., Corkum, P.B.   +47 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Can localised 19F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response? [PDF]

, 2010
Background 5-Fluorouracil remains widely used in colorectal cancer treatment more than 40 years after its development. 19F magnetic resonance spectroscopy can be used in vivo to measure 5FU’s half-life and metabolism to cytotoxic fluoronucleotides ...
Griffiths, John R., Ladroue, Christophe, Lofts, F, Lofts, Fiona, Griffiths, JR, John R. Griffiths, Marion Stubbs, Stubbs, Marion, Franklyn A. Howe, Fiona Lofts, McIntyre, DJ, Ladroue, C, Howe, FA, Howe, Franklyn A., McIntyre, Dominick J. O., Dominick J. O. McIntyre, Stubbs, M, Christophe Ladroue   +17 more
core   +1 more source