Results 41 to 50 of about 17,221,339 (259)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Astrophysical JournalBrown dwarfs with measured dynamical masses and spectra from direct imaging are benchmarks that anchor substellar atmosphere cooling and evolution models.
Briley L. Lewis +12 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
HD 206893 B at High Spectral Resolution with the Keck Planet Imager and Characterizer
The Astronomical JournalWe present an atmospheric characterization and orbital analysis of HD 206893 B, an exceptionally red, L/T-transition substellar companion in a multiplanetary system, via Keck Planet Imager and Characterizer (KPIC) high-resolution ( R ∼ 35,000) K- band ...
Ben Sappey +40 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The Astrophysical JournalThe accretion/ejection processes in T Tauri stars are fundamental to their physical evolution, while also impacting the properties and evolution of the circumstellar material at a time when planet formation takes place.
Sebastián Jorquera +16 more
doaj +1 more source
NMR characterization of foldedness for the production of E3 RING domains [PDF]
, 2010 We summarize the use of NMR spectroscopy in the production and the screening of stability and foldedness of protein domains, and apply it to the RING domains of E3 ubiquitin-ligases.
NMR Spectroscopy +6 more
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
High-contrast JWST-MIRI Spectroscopy of Planet-forming Disks for the JDISC Survey
The Astrophysical JournalThe JWST Disk Infrared Spectral Chemistry Survey (JDISCS) aims to understand the evolution of the chemistry of inner protoplanetary disks using the Mid-InfraRed Instrument (MIRI) on the James Webb Space Telescope (JWST).
Klaus M. Pontoppidan +28 more
doaj +1 more source
Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus [PDF]
, 2006 Background and aims: Endoscopic surveillance of Barrett’s oesophagus currently relies on multiple random biopsies. This approach is time consuming, has a poor diagnostic yield, and significant interobserver variability. Elastic scattering spectroscopy is
Lovat, L.B. +13 more
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