Results 111 to 120 of about 1,232,763 (338)

Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic

open access: yesAngewandte Chemie, EarlyView.
Proteomics and redoxomics are efficient to quantify the effects of bacterial lipopolysaccharide in intestinal epithelial cells (HT29) at the proteome and at the Cys‐redoxome levels. Oxidative stress is the initial trigger of LPS leading to inflammation.
Martha Zoumpoulaki   +14 more
wiley   +2 more sources

Powerful genome-wide design and robust statistical inference in two-sample summary-data Mendelian randomization [PDF]

open access: yesarXiv, 2018
Two-sample summary-data Mendelian randomization (MR) has become a popular research design to estimate the causal effect of risk exposures. With the sample size of GWAS continuing to increase, it is now possible to utilize genetic instruments that are only weakly associated with the exposure.
arxiv  

Correlation Between Blood Glucose Level and Cerebral Small Vessel Disease Markers in Neurologically Asymptomatic, Nondiabetic Individuals

open access: yesAGING MEDICINE, EarlyView.
The prevalence of neurologically asymptomatic CSVD is common in the nondiabetic population. Glycated hemoglobin A1c correlated with periventricular white matter hyperintensities. Fasting blood glucose was associated with deep cerebral microbleeds. Better control of blood glucose may have a beneficial effect on reducing the risk of CSVD.
Xinxin Ma   +7 more
wiley   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

open access: yesAggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai   +6 more
wiley   +1 more source

Underweight and obesity are related to higher mortality in patients undergoing coronary angiography: The KARDIO invasive cardiology register study

open access: yesCatheterization and Cardiovascular Interventions, Volume 100, Issue 7, Page 1242-1251, December 1, 2022., 2022
Abstract Background In patients with some cardiovascular disease conditions, slightly elevated body mass index (BMI) is associated with a lower mortality risk (termed “obesity paradox”). It is uncertain, however, if this obesity paradox exists in patients who have had invasive cardiology procedures.
Jari A. Laukkanen   +16 more
wiley   +1 more source

1H NMR spectroscopy quantifies visibility of lipoproteins, subclasses, and lipids at varied temperatures and pressures

open access: yesJournal of Lipid Research, 2019
NMR-based quantification of human lipoprotein (sub)classes is a powerful high-throughput method for medical diagnostics. We evaluated select proton NMR signals of serum lipoproteins for elucidating the physicochemical features and the absolute NMR ...
Daniela Baumstark   +8 more
doaj  

High-density lipoprotein in chronic renal failure and after renal transplantation. [PDF]

open access: bronze, 1979
Elliott Savdie   +3 more
openalex   +1 more source

HDL-apolipoprotein A-I exchange is independently associated with cholesterol efflux capacity

open access: yesJournal of Lipid Research, 2015
HDL is the primary mediator of cholesterol mobilization from the periphery to the liver via reverse cholesterol transport (RCT). A critical first step in this process is the uptake of cholesterol from lipid-loaded macrophages by HDL, a function of HDL ...
Mark S. Borja   +10 more
doaj  

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